DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALiX and alx-1

DIOPT Version :9

Sequence 1:	NP_651582.1	Gene:	ALiX / 43330	FlyBaseID:	FBgn0086346	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_001022713.1	Gene:	alx-1 / 176410	WormBaseID:	WBGene00007010	Length:	882	Species:	Caenorhabditis elegans

Alignment Length:	889	Identity:	347/889 - (39%)
Similarity:	525/889 - (59%)	Gaps:	77/889 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FLGVPLKKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEASLEI 68
            ||..|||..:|||::|||.:.|.:.|| .|:..:....|||.|.:|.|:.|..:..:|::::|::
Worm     6 FLSAPLKSTNEVDLVKPLTSYIDNVYN-TSDNNRSDVAEAVQELNKLRSKACCQPLDKHQSALDV 69

  Fly    69 VYAYYDQICALETKISVSELQIP--FKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQS 131
            :..||||:.|:|.||.:|..|.|  |||||||||||:|..:.||:.:...:|:..|||||.:|.|
Worm    70 LTRYYDQLVAIENKIIISATQNPVVFKWKDAFDKGSLFSSRASLSLSDGSFERAAVLFNIGSLMS 134

  Fly   132 NIAANQSLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQE 196
            .|.|.|...:||.:|::.||.|||||:|..|:......|..||||||..|||..|.|||.|||||
Worm   135 QIGAAQQFHTDDEIKVSAKLFQQSAGVFARLRDVVLGMVQQEPTPDLMPDTLAALSALMTAQAQE 199

  Fly   197 VFILKAIKDNLKDQIIAKLCCQAEESYADVLRAMQKESVRSLWEKEWIPTIAGKQAGFHALTQLY 261
            ...:|..||.:|...:.|:..|..|.|::..:.|.|:.||.||:|:|...::||...:.||.|.:
Worm   200 AIYIKGHKDKMKATSMVKISAQVAEFYSEAQKMMSKDIVRGLWDKDWSAIVSGKNLAYQALAQYH 264

  Fly   262 QSLVCRAAKKIGEEIARLRNAIDLFKAAQTRSGNETYL--------DEYFSRAKRNLTESTKDNE 318
            ||.||..|::|||:::||..::.||..||      .||        |.|.|.:|.: ..:.|||:
Worm   265 QSEVCGEARQIGEQLSRLAESLKLFDTAQ------KYLPRDITGIWDIYPSVSKAH-AAAKKDND 322

  Fly   319 FIYNEIIPELSTLTSPGKAQLAKPLPIAVPLAENFKDIFSSLVPVELHRALTASDMRRNEIVNVE 383
            |||:|.:.:..||.:..||.||||.|:..|:..:|:|:|:.||||::|.|:.:.|.|:.|:||:|
Worm   323 FIYHEKVSDFRTLPTLPKAVLAKPTPMQTPMTPSFRDMFAVLVPVQVHNAMQSYDARKAELVNME 387

  Fly   384 IMKLREATQTLNAVLASLNLPAAVETADGNSGLPPSLKEKANEVRQKGGIENVQTMLKDLPELLN 448
            .:::|||||.:|.||||||||||::.......||.|||.|:.:::|.||...:..:..:||.|..
Worm   388 TVRMREATQLMNGVLASLNLPAALDDVTSTETLPESLKLKSAKLKQNGGSSEIMRLFSELPTLYQ 452

  Fly   449 RNREILDETERLLDEERDSDNQLRAQFKDRWTRISSDKLTEMFRTNAKKYREVITNAIEADKVVR 513
            ||.:||.||.|:|:||::||:.:|.|...:|||:||::||....|...|||.::..|..|||:|:
Worm   453 RNEDILTETSRILNEEKESDDTMRKQLGTKWTRMSSEQLTGPLVTEIGKYRGILHTASNADKMVK 517

  Fly   514 QKFEANQKGIQLLSLPPDQIQQSLPSASGSVDPNCSSVQRLKKLMDDVETIKAEREAIESELKGA 578
            :|||::::||:|||....:::.|:|..:........:|::|::.|.....:..:||.:|.|||..
Worm   518 EKFESHRQGIELLSKNESELRSSIPGQTAHATGETDTVRQLRQFMSQWNEVTTDRELLEKELKNT 582

  Fly   579 TFNMKDEFLIALQKDGAIDEPALSLARIGQVLNPLQQQVRESVERQQSLVSEIQSAHGAFVSE-T 642
            ..::.::||.|:.::..|:|..:|..:|.|:...|:::|:.|::.|::|:::||:|:..|..| |
Worm   583 NCDIANDFLKAMAENQLINEEHISKEKIAQIFGDLKRRVQSSLDTQETLMNQIQAANNTFTGEKT 647

  Fly   643 G-SCGSSRDTLYQELATAFDSYIELSGNLQEGTKFYNDLTQLLVVFQNKISDFVFARKTEKEELL 706
            | |.|:.|:.:.:.||.|.|:|:||..||:||||||||||.:||..|.|:|||.|||:||||:|:
Worm   648 GSSTGAERERILKMLAQASDAYVELKANLEEGTKFYNDLTPILVRLQQKVSDFAFARQTEKEDLM 712

  Fly   707 KDL-----TTESSRQACPATPALPSHYASTSGSGSDIPPGSAPSVP----PAASTAN--IPYPAQ 760
            :.|     :.::::.......:|.|.|. |.|:.:...|.:||..|    |||.:..  ||.|..
Worm   713 RQLQLSIVSGQAAKAVVDGVNSLVSSYL-TGGTNAAQSPANAPPRPPPPRPAAPSVESPIPPPRT 776

  Fly   761 VQGMPIPYGAQPGVPYPAYVP-----APMPQSFNPYATLPYPGNYQYQGFPQGPP-----PGH-- 813
            .|.|.    |.||.| |.|.|     .|..|.|.     .:||.|| |..|.|.|     |.:
Worm   777 QQSMQ----ATPGAP-PQYNPYQQQQQPQMQQFQ-----QHPGYYQ-QPMPYGQPQPMFQPQYQP 830

  Fly   814 -----YGTYPGSYAN---------QQGGYP--------NQKPPG 835
                 |.|:||::.:         ||||:|        ||:..|
Worm   831 TFAAPYPTFPGAFPSYQQQWPQQQQQGGFPPNPQFGQQNQQQGG 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALiX	NP_651582.1	BRO1_Alix	2..347	CDD:185763	148/352 (42%)
		V_Alix	362..698	CDD:185748	137/337 (41%)
		ALIX_LYPXL_bnd	415..701	CDD:290660	113/287 (39%)
		MFMR	733..822	CDD:285072	36/111 (32%)
alx-1	NP_001022713.1	BRO1_Alix	4..351	CDD:185763	148/352 (42%)
		V_Alix	366..704	CDD:185748	137/337 (41%)
		ALIX_LYPXL_bnd	419..707	CDD:290660	113/287 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167274
Domainoid	1	1.000	303	1.000	Domainoid score	I760
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22614
Inparanoid	1	1.050	601	1.000	Inparanoid score	I511
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S2147
OMA	1	1.010	-	-		QHG53532
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	1	1.000	-	-		FOG0003348
OrthoInspector	1	1.000	-	-		oto18941
orthoMCL	1	0.900	-	-		OOG6_102685
Panther	1	1.100	-	-	LDO	PTHR23030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	1	1.000	-	-		X4332
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890