DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ALiX and Ptpn23

DIOPT Version :9

Sequence 1:NP_651582.1 Gene:ALiX / 43330 FlyBaseID:FBgn0086346 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_001074512.1 Gene:Ptpn23 / 104831 MGIID:2144837 Length:1692 Species:Mus musculus


Alignment Length:897 Identity:228/897 - (25%)
Similarity:387/897 - (43%) Gaps:139/897 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LKKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEASLEIVYAYY 73
            ||:..:......:...:...|.    |....|.|.:.:....|..|| :....:| ...::..|.
Mouse    14 LKEAGDFHFQSAVKKFVLKNYG----ENPEAYNEELKKLELLRQNAI-RVARDFE-GCSVLRKYL 72

  Fly    74 DQICALETKI---SVSELQIPFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQSNIAA 135
            .|:..|::::   |..|..:...|.:      ||.|| |::|..:.||:.|:|:|:.||.|.:.|
Mouse    73 GQLHYLQSRVPMGSGQEAAVAVTWTE------IFSGK-SVSHEDIKYEQACILYNLGALHSMLGA 130

  Fly   136 NQSLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQEVFIL 200
            .....|::|:|::....|.:||.|.||:...|.|.    :.|:|:..||:...||:.||||..:.
Mouse   131 MDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAF----SVDMSRQILTLNVNLMLGQAQECLLE 191

  Fly   201 KAIKDNLKDQIIAKLCCQAEESYADVLRAMQKESVRSLW---EKEWIPTIAGKQAGFHALTQLYQ 262
            |::.||.|..::|::..|..:.|.:..||::.....||.   :|:|...:..|...|.|:..|:.
Mouse   192 KSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHM 256

  Fly   263 SLVCRAAKKIGEEIARLRNAID-LFKAAQTRSGNETYLDEYFSRA------KRNLTESTKDNEFI 320
            .......:|.||.:|..::|:| |.:|.:...|....:.:....|      |.|  .:.|||:||
Mouse   257 GKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFAMDVIGGKYN--SAKKDNDFI 319

  Fly   321 YNEIIPELSTLTSPGKAQLAKPLPI-AVPLAENFKDIFSSLVPVELHRALTASDMRRNEIVNVEI 384
            |:|.:|.|.||.....|.|.||||: ....|....|||:.|||:..|.|.:.....:.:::...:
Mouse   320 YHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIF
AKLVPMAAHEASSLYSEEKAKLLREML 384

  Fly   385 MKLREATQTLNAVLASLNL-PAAVETADGNSGLPPSLKEK--ANEVRQ-------------KGGI 433
            .|:.:..:.|:..:.|:.| |..|:..|..:.:||.|.||  |..||.             .|..
Mouse   385 AKIEDKNEVLDQFMDSMQLDPETVDNLDAYNHIPPQLMEKCAALSVRPDTVKNLVQSMQVLSGVF 449

  Fly   434 ENVQTMLKDLPELLNRNREILDETERLLDEERDSDNQLRAQFKDRWTRISSDKLTEMFRTNAKKY 498
            .:|:..|||:       |::|:|.|.   :|:.....|..........::..:|.|:.|..| ||
Mouse   450 TDVEASLKDI-------RDLLEEDEL---QEQKLQETLGQAGAGPGPSVAKAELAEVRREWA-KY 503

  Fly   499 REVITNAIEADKVVRQKFEANQKGIQLLSLPPDQIQQSLPSASGSVDPNCSSV-QRLKKLMDDVE 562
            .||...|...:..:.:....:...::|||.|.||::.:||:.  ::.|...:| |.||:::..|:
Mouse   504 MEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTP--ALTPEDKAVLQNLKRILAKVQ 566

  Fly   563 TIKAEREAIESELKGATFNMKDEFLIALQKDGAIDEPAL---SLARIGQVLNPLQQQV--RESVE 622
            .::.:|.::|.:|:  ....||:...:|......:...|   .|.:..|:...|:|.:  :::|.
Mouse   567 EMRDQRVSLEQQLR--ELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDNVL 629

  Fly   623 RQQSLVSEIQSAHGAFVSETGSCGSSRDTLYQELATAFDSYIELSGNLQEGTKFYNDLTQLLVVF 687
            |..:..:...:|....:||.....:|  || |.|..::::|.:|....|||..||.||...:...
Mouse   630 RALTEANVQYAAVRRVLSELDQKWNS--TL-QTLVASYEAYEDLMKKSQEGKDFYADLESKVATL 691

  Fly   688 QNKISDFVFARKTEKEELLKDLTTESSRQACPATPALPSHYASTSGSGSDIPPGSAP----SVPP 748
            ..:......|::..:::|   |..|..::|.|..|..|....|....|..:..|..|    |:||
Mouse   692 LERAQSICRAQE
AARQQL---LDRELKKKAPPPRPTAPKPLLSRREEGEAVEAGDTPEELRSLPP 753

  Fly   749 ------------AASTANI-----PYPAQ-------VQGMPIPYGAQPG---------------- 773
                        ..:||.:     |:|:.       :.| |:|.|...|                
Mouse   754 DMMVGPRLPDPFLGTTAPLHFSPGPFPSSTGPATHYLSG-PLPPGTYSGPTQLMQPRAAVPMAPA 817

  Fly   774 ---VPYPAY------VPAPMPQS---FNPYATL--PYPGNYQYQGFPQGPPP 811
               .|.|||      ||...||.   .:|||.:  |.|    ..|.|..|||
Mouse   818 TVLYPAPAYTSELGLVPRSSPQHGIVSSPYAGVGPPQP----VVGLPSAPPP 865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ALiXNP_651582.1 BRO1_Alix 2..347 CDD:185763 98/351 (28%)
V_Alix 362..698 CDD:185748 82/357 (23%)
ALIX_LYPXL_bnd 415..701 CDD:290660 73/306 (24%)
MFMR 733..822 CDD:285072 33/137 (24%)
Ptpn23NP_001074512.1 BRO1_HD-PTP_like 2..357 CDD:185762 100/361 (28%)
TPR 1 250..283 9/32 (28%)
V_HD-PTP_like 362..702 CDD:185747 82/357 (23%)
TPR 2 374..407 5/32 (16%)
ALIX_LYPXL_bnd 417..703 CDD:290660 73/303 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..788 16/76 (21%)
His 773..1186 25/98 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 884..923
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..1199
21 X 2 AA approximate tandem repeats of P-Q 977..1018
Y_phosphatase 1276..1506 CDD:278528
PTPc 1276..1505 CDD:238006
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1574..1638
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2220
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R147
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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