DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALiX and PDCD6IP

DIOPT Version :9

Sequence 1:	NP_651582.1	Gene:	ALiX / 43330	FlyBaseID:	FBgn0086346	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_001155901.1	Gene:	PDCD6IP / 10015	HGNCID:	8766	Length:	873	Species:	Homo sapiens

Alignment Length:	882	Identity:	366/882 - (41%)
Similarity:	534/882 - (60%)	Gaps:	60/882 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKFLGVPLKKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEAS 65
            |:.|:.|.|||.||||:.|||...||.||....||: .:|..|..|.||.|..|:.:..:|:|.:
Human     1 MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQ-AQYCRAAEELSKLRRAAVGRPLDKHEGA 64

  Fly    66 LEIVYAYYDQICALETKISVSELQI--PFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAA 128
            ||.:..||||||::|.|...||.||  .|.|||||||||:|||.:.|...||.|||.|||||.||
Human    65 LETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAA 129

  Fly   129 LQSNIAANQSLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQ 193
            |.|.|||.|:||:|:|||:..|..|.::|.|.::|....:|:..|||.|:|.||:..|..:|:||
Human   130 LASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQ 194

  Fly   194 AQEVFILKAIKDNLKDQIIAKLCCQAEESYADVLRAMQ-KESV-RSLWEKEWIPTIAGKQAGFHA 256
            |||||.|||.:|.:||.|||||..||.:.:.|..:..| |::: :..:.:|..|.:|.|.....|
Human   195 AQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKYFYFQEVFPVLAAKHCIMQA 259

  Fly   257 LTQLYQSLVCRAAKKIGEEIARLRNAIDLFKAAQTRSGNETYLDEYFSRAKRNLTESTKDNEFIY 321
            ..:.:||::.:..||.|||||||::|.:|.|...:|......:.::..:..|.|..:.|||:|||
Human   260 NAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKDFSDKINRALAAAKKDNDFIY 324

  Fly   322 NEIIPELSTLTSPGKAQLAKPLPIAVPLAENFKDIFSSLVPVELHRALTASDMRRNEIVNVEIMK 386
            ::.:|:|..|...|||.|.|..|:.||:::.|.|:|..:|||.:.::|.|.:.|:.::||..|.:
Human   325 HDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQ 389

  Fly   387 LREATQTLNAVLASLNLPAAVETADGNSGLPPSLKEKANEVRQKGGIENVQTMLKDLPELLNRNR 451
            :||||...|.||||||||||:|...|:: :|.|:..|:..|.::|||:.|..::|:|||||.|||
Human   390 MREATTLANGVLASLNLPAAIEDVSGDT-VPQSILTKSRSVIEQGGIQTVDQLIKELPELLQRNR 453

  Fly   452 EILDETERLLDEERDSDNQLRAQFKDRWTRISSDKLTEMFRTNAKKYREVITNAIEADKVVRQKF 516
            |||||:.||||||..:||.|||:||:||.|..|::|.:..|.....:|.|:..|::||..|::.:
Human   454 EILDESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGTNFRTVLDKAVQADGQVKECY 518

  Fly   517 EANQKGIQLLSLPPDQIQQSLPSASGSVDPNCSSVQR-LKKLMDDVETIKAEREAIESELKGATF 580
            ::::..|.||..|..::..::|||:.:.....|.|.. ||.|:.:::.:|.|||.:|::||...|
Human   519 QSHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSVNF 583

  Fly   581 NMKDEFLIALQKDGAIDEPALSLARIGQVLNPLQQQVRESVERQQSLVSEIQSAHGAF--VSETG 643
            :|..:||.||.:||.|:|.|||:..:.:|...|..:|:||:::|:.|:..||.:|..|  :.::.
Human   584 DMTSKFLTALAQDGVINEEALSVTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSN 648

  Fly   644 SCGSSRDTLYQELATAFDSYIELSGNLQEGTKFYNDLTQLLVVFQNKISDFVFARKTEKEELLKD 708
            :..:.|:.:.:.||||:|:::||..||:|||||||:||::||.||||.||.|||||||::|||||
Human   649 NEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKD 713

  Fly   709 LTTESSRQACPATPAL--PSHYASTSGSGSDIPPGSAPSV-------PPA-------------AS 751
            |....:|:  |:.|::  |::.:|.:|..:..||..||..       |||             ::
Human   714 LQQSIARE--PSAPSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSA 776

  Fly   752 TANIPY-----------------PAQVQGMPIPYGAQPGVPYPAYVPAPMPQSFNPYA----TLP 795
            ||..|.                 |.|.||.|.|  ..||  ||.|...|||..:||||    .:|
Human   777 TAPSPVGAGTAAPAPSQTPGSAPPPQAQGPPYP--TYPG--YPGYCQMPMPMGYNPYAYGQYNMP 837

  Fly   796 YPGNYQYQGFPQGPPPG-HYGTYPGSYANQQGGYPNQ 831
            ||..| :|...|.|.|| ...:||.....||..||.|
Human   838 YPPVY-HQSPGQAPYPGPQQPSYPFPQPPQQSYYPQQ 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALiX	NP_651582.1	BRO1_Alix	2..347	CDD:185763	154/348 (44%)
		V_Alix	362..698	CDD:185748	144/338 (43%)
		ALIX_LYPXL_bnd	415..701	CDD:290660	122/288 (42%)
		MFMR	733..822	CDD:285072	40/130 (31%)
PDCD6IP	NP_001155901.1	Interaction with SDCBP. /evidence=ECO:0000269\|PubMed:22660413	423..873		177/456 (39%)
		Self-association	508..873		135/371 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..814		24/101 (24%)
		Interaction with TSG101	722..725		1/2 (50%)
		Interaction with CEP55. /evidence=ECO:0000269\|PubMed:18641129	806..811		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..873		15/36 (42%)
		Essential to promote virus budding	869..873		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	307	1.000	Domainoid score	I1350
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22614
Inparanoid	1	1.050	633	1.000	Inparanoid score	I842
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S2147
OMA	1	1.010	-	-		QHG53532
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	1	1.000	-	-		FOG0003348
OrthoInspector	1	1.000	-	-		oto88928
orthoMCL	1	0.900	-	-		OOG6_102685
Panther	1	1.100	-	-	LDO	PTHR23030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	1	1.000	-	-		X4332
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820