DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ALiX and ptpn23a

DIOPT Version :9

Sequence 1:	NP_651582.1	Gene:	ALiX / 43330	FlyBaseID:	FBgn0086346	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	XP_005158252.1	Gene:	ptpn23a / 100007322	ZFINID:	ZDB-GENE-100921-24	Length:	2003	Species:	Danio rerio

Alignment Length:	920	Identity:	230/920 - (25%)
Similarity:	392/920 - (42%)	Gaps:	169/920 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTA--IWKFFEKYEASLEIVYA 71
            ||:..|......:...|...|.    |:...|.|.:.:..:.|.:|  :.:.||    ....:..
Zfish    14 LKEAGEFQFSPTVKQFILKNYG----EDPDNYNEQLKKLEQLRQSAVNVTRDFE----GCSTLRK 70

  Fly    72 YYDQICALETKISV---SELQIPFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQSNI 133
            |:.|:..|::::.:   .|..:|..|.:      ||.|| ::||..:.||:.|:|:|:.||.|.:
Zfish    71 YFGQLHYLQSRVPLGLGQEAAVPISWTE------IFSGK-TVTHEDICYEQACILYNLGALHSML 128

  Fly   134 AANQSLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQEVF 198
            .|..:..|::|:|::....|.|||.|.||:.....:.    :.|:|...|.:...||:.||||..
Zfish   129 GAMDNRVSEEGMKVSCTHFQCSAGAFAYLRDHFSHSY----SVDMSHQILNLNINLMLGQAQECL 189

  Fly   199 ILKAIKDNLKDQIIAKLCCQAEESYADVLRAMQKESVRSLW---EKEWIPTIAGKQAGFHALTQL 260
            :.|::.||.|..::|::..|..:.|.:..||::.....|:.   :|:|...:..|...|.|:..|
Zfish   190 LEKSMLDNRKSFLVARISAQVVDYYKEACRALENSETASMLGKIQKDWKKLVQMKIYYFAAIAHL 254

  Fly   261 YQSLVCRAAKKIGEEIARLRNAID-LFKAAQTRSGNETYLDE-----------YFSRAKRNLTES 313
            :........:|.||.:|.|::::| |.:|.:...|....:.|           .|:.||
Zfish   255 HMGKQAEEQQKYGERVAYLQSSLDKLGEAIKLAKGQPDSVQEALRFTMDVIGGKFNSAK------ 313

  Fly   314 TKDNEFIYNEIIPELSTLTSPGKAQLAKPLPI-AVPLAENFKDIFSSLVPVELHRALTASDMRRN 377
             |||:|||:|.:|.|.||||...|.|.|.||: ....:....|||:.|||:..|.|.:.....:.
Zfish   314 -KDNDFIYHESVPSLETLTSVKGAPLVKALPVNPTDPSVTGPDIFAKLVPMAAHEASSLYSEEKA 377

  Fly   378 EIVNVEIMKLREATQTLNAVLASLNL-PAAVETADGNSGLPPSLKEK--ANEVRQ---KGGIENV 436
            :::...:.|:....:||...:.||.| |.:|:..:..:.||..|.||  |..||.   |..|:::
Zfish   378 KLLRDVMAKVDNKNETLEQFMDSLGLDPESVDNMEMYNTLPTVLMEKCAALSVRPDTVKNLIQSM 442

  Fly   437 QTM---LKDLPELLNRNREILDETERLLDEERDSDNQLRAQ-FKDRWTRISSDKLTEMFRTNAKK 497
            |.:   ..|:...|...|::|||.|   .||:..:..:..| ..:|     ...|.|: |.:.:|
Zfish   443 QVLSGVFTDVEASLREIRDVLDEDE---TEEQSLEEAVGKQAVPER-----PSTLAEL-RRDLEK 498

  Fly   498 YREVITNAIEADKVVRQKFEANQKGIQLLSLPPDQIQQSLPSASGSVDPNCSSVQRLKKLMDDVE 562
            |.|....|...:..:.:....:...::||..|.|.::::||....|.| ..:.:|.:|:::..|:
Zfish   499 YLEAHEKASFTNTELHRAMNLHISNLRLLGGPLDTLREALPRPQLSED-EMAGLQTMKRILGKVQ 562

  Fly   563 TIKAEREAIESELKGATFNMKDEFLIALQKDGAIDEPAL---SLARIGQVLNPLQQQVRESVERQ 624
            .::.:|.::|.:|:...  .:|:...||......|...|   .|.:..||    :..:.:::..|
Zfish   563 EMRDQRSSLEKQLRDLI--QQDDITTALVTTERADMKKLFEEQLKKYEQV----KVYIDQNLAAQ 621

  Fly   625 QSLVSEIQSAHGAF------VSETGSCGSSRDTLYQELATAFDSYIELSGNLQEGTKFYNDLTQL 683
            ::::..:..|:..:      ::||....:|   ..|.|..::::|.:|....|||.:||.||...
Zfish   622 ENILKALTEANVQYATVRKGLTETEHKWNS---TVQMLVASYEAYEDLMKKSQEGKEFYEDLETK 683

  Fly   684 LVVFQNKISDFVFARKTEKEELLKDLTTESSRQACPATPALPS-----------------HYAST 731
            ......|......|||.|::.    :|....::..|..|..|.                 ..|..
Zfish   684 ASRLLEKSKTVCKARKEERQA----ITERELKKKAPQRPTAPKPAQNKGQNMGPSISDDPELAEL 744

  Fly   732 SGS----GSDIP-----------------------PGSAPSVPPAAST---------ANIPYP-- 758
            |.:    |.|:|                       |||....|.|.||         .|:|.|
Zfish   745 SAAILALGGDLPEELRSLPPELTIPSSAHPVSGAAPGSVLRWPGANSTLHYGQHRFPQNLPPPEV 809

  Fly   759 -AQVQGMPIPYGAQPGVPYPAYVPAPMPQSFNPYATLPYPGNYQYQGFPQG------PPPGHYGT 816
             ||:...|.|               |:.|||:|  ::|.|...|.| |||.      |||...|.
Zfish   810 LAQISRFPTP---------------PLSQSFSP--SVPQPSLMQQQ-FPQMPNPQVLPPPPVSGY 856

  Fly   817 YPGSYANQQG 826
            :|....||.|
Zfish   857 HPQPSQNQPG 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALiX	NP_651582.1	BRO1_Alix	2..347	CDD:185763	99/358 (28%)
		V_Alix	362..698	CDD:185748	79/354 (22%)
		ALIX_LYPXL_bnd	415..701	CDD:290660	71/303 (23%)
		MFMR	733..822	CDD:285072	34/133 (26%)
ptpn23a	XP_005158252.1	BRO1_HD-PTP_like	2..357	CDD:185762	100/368 (27%)
		V_HD-PTP_like	362..698	CDD:185747	79/354 (22%)
		ALIX_LYPXL_bnd	416..701	CDD:290660	71/303 (23%)
		Y_phosphatase	1548..1780	CDD:278528
		PTPc	1549..1779	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850