DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HSPBAP1 and Kdm8

DIOPT Version :9

Sequence 1:	NP_651581.2	Gene:	HSPBAP1 / 43329	FlyBaseID:	FBgn0263025	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_084118.1	Gene:	Kdm8 / 77035	MGIID:	1924285	Length:	414	Species:	Mus musculus

Alignment Length:	236	Identity:	58/236 - (24%)
Similarity:	97/236 - (41%)	Gaps:	41/236 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PLVLEQFPLKWECFEGSLHDWCKRFDKEATCLPAFELMALADSSTPQWERKRTKSSQLLNMQQFL 81
            |::||.....|.|    :..|..::.:|........:...:..:...|      |..|:.:.:|:
Mouse   203 PVILEGVADHWPC----MKKWSLQYIQEIAGCRTVPVEVGSRYTDEDW------SQTLMTVDEFI 257

  Fly    82 RKYGVLDGDSTHWAAYQYKKADEVPLSCRSGIGFSSFGFPD---IGN------DYRFWLGSEQAN 137
            :|:.:.:.....:.| |::..|::|...|      ....||   :||      ....|.|.:...
Mouse   258 QKFILSEAKDVGYLA-QHQLFDQIPELKR------DISIPDYCCLGNGEEEEITINAWFGPQGTI 315

  Fly   138 TPCHYDTFGVNIVVQVHGCKSWLLFPPETPLQSTRI-PYE-----ETSVYCLENFYAPDPAKISS 196
            :|.|.|. ..|.:|||.|.|...|:.|:   :|..: |:|     .||...:||   ||..|...
Mouse   316 SPLHQDP-QQNFLVQVLGRKYIRLYSPQ---ESEAVYPHETHILHNTSQVDVEN---PDLEKFPK 373

  Fly   197 YEHLGRQAYHCNLQPGNVLIVPRHWWHYVEAKSTSLSVNYW 237
            :..  .....|.|.||:.|.:|..:||||.:...|.||::|
Mouse   374 FTE--APFLSCILSPGDTLFIPAKYWHYVRSLDLSFSVSFW 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPBAP1	NP_651581.2	cupin_like	11..237	CDD:304367	57/234 (24%)
Kdm8	NP_084118.1	Interaction with RCCD1. /evidence=ECO:0000250\|UniProtKB:Q8N371	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..169
		Cupin_8	189..414	CDD:290351	58/236 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820