DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sce and RNF2

DIOPT Version :9

Sequence 1:	NP_477509.1	Gene:	Sce / 43327	FlyBaseID:	FBgn0003330	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_009143.1	Gene:	RNF2 / 6045	HGNCID:	10061	Length:	336	Species:	Homo sapiens

Alignment Length:	430	Identity:	194/430 - (45%)
Similarity:	245/430 - (56%)	Gaps:	120/430 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NKTWELSLYELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCSDCIVT 73
            :||||||||||||.|||.|||..||.||||||||||||||||||||.||||||||||||:|||:|
Human    14 SKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIIT 78

  Fly    74 ALRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQTQSQQALVNS 138
            |||||||||||||||||||||||.|||||.|||||||||:||||.||:|:|:.|:..:||||.:|
Human    79 ALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHS 143

  Fly   139 INEGIKLQSQNRPQRFRTKGGGGGGGGGGNGNGAANVAAPPAPGAPTAVGRNASNQMHVHDTASN 203
            |.||:|:|:.||.||.:.:....|.|...||:                              :|:
Human   144 IEEGLKIQAMNRLQRGKKQQIENGSGAEDNGD------------------------------SSH 178

  Fly   204 DSNSNTNSIDRENRDPGHSGTSAASAITSASNAAPSSSANSGASTSATRMQVDDASNPPSVRSTP 268
            .||::|:|    |::.|            .||....:|.:||       :::|
Human   179 CSNASTHS----NQEAG------------PSNKRTKTSDDSG-------LELD------------ 208

  Fly   269 SPVPSNSSSSKPKRAMSVLTSERSEESESDSQMDCRTEGDSNIDTEGEGNGELGINDEIELVFKP 333
                 |:::     ||::           |..||    |.|                ||||||:|
Human   209 -----NNNA-----AMAI-----------DPVMD----GAS----------------EIELVFRP 232

  Fly   334 HPTEMSADNQLIRALKENCVRYIKTTANATVDHLSKYLAMRLTLDLGADLPEACRV-------LN 391
            |||.|..|:..       ..|||||:.||||||||||||:||.|:......|:.::       ..
Human   233 HPTLMEKDDSA-------QTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQ 290

  Fly   392 FCIYVAPQPQQLVILNGNQTLHQVNDKFWKVNKPMEMYYS 431
            :.||:|....|..:|||:.:|..|::|:||||||||:||:
Human   291 YTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYA 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sce	NP_477509.1	RING	45..89	CDD:238093	40/43 (93%)
Sce	NP_477509.1	RAWUL	336..431	CDD:292824	43/101 (43%)
RNF2	NP_009143.1	Interaction with HIP2. /evidence=ECO:0000269\|PubMed:11513855	2..179		121/194 (62%)
		COG5222	<11..>103	CDD:227547	79/88 (90%)
		RING-HC_RING1_like	51..91	CDD:319445	36/39 (92%)
		Interaction with nucleosomes via an acidic patch on histone H2A and histone H2B. /evidence=ECO:0000269\|PubMed:25355358	93..98		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..208		18/103 (17%)
		RAWUL_RING2	225..330	CDD:340687	52/111 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4916
eggNOG	1	0.900	-	-		E1_KOG0311
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2199
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2431
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48576
OrthoDB	1	1.010	-	-		D1319463at2759
OrthoFinder	1	1.000	-	-		FOG0003138
OrthoInspector	1	1.000	-	-		otm41319
orthoMCL	1	0.900	-	-		OOG6_105342
Panther	1	1.100	-	-	LDO	PTHR46076
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	1	1.000	-	-		X2531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870