DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sce and RING1

DIOPT Version :10

Sequence 1:NP_477509.1 Gene:Sce / 43327 FlyBaseID:FBgn0003330 Length:435 Species:Drosophila melanogaster
Sequence 2:NP_002922.2 Gene:RING1 / 6015 HGNCID:10018 Length:406 Species:Homo sapiens


Alignment Length:492 Identity:203/492 - (41%)
Similarity:238/492 - (48%) Gaps:153/492 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTSLDPAPN--KTWELSLYELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECL 63
            ||:...|.|  ||||||||||.|.|||.|.|.||||||||||||||||||||||||.||||||||
Human     1 MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECL 65

  Fly    64 HRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQ 128
            |||||||||||||||||||||||||||||||||.|||||.||||||||||||||.|::|:.:.::
Human    66 HRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSR 130

  Fly   129 TQSQQALVNSINEGIKLQSQNRPQRFR----------TKGGGGGGGGGGNGNG-------AANVA 176
            ..:||||.:||.||:::|:.:|.||.|          |..||.|..|.|.|:|       |.:.|
Human   131 LHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGEGDGEDVSSDSAPDSA 195

  Fly   177 APPAPGAPTAVGRNASNQMHVHDTASNDSNSNTNSIDRENRDPGHSGTSAASAITSASNAAPSSS 241
            ..|||..|...|...|:.                       ..|..||...     ...|....|
Human   196 PGPAPKRPRGGGAGGSSV-----------------------GTGGGGTGGV-----GGGAGSEDS 232

  Fly   242 ANSGASTSATRMQVDDASNPPSVRSTPSPVPSNSSSSKPKRAMSVLTSERSEESESDSQMDCRTE 306
            .:.|.:.....:      .|||....|||                                    
Human   233 GDRGGTLGGGTL------GPPSPPGAPSP------------------------------------ 255

  Fly   307 GDSNIDTEGEGNGELGINDEIELVFKPHPTEMSADNQLIRALKENC-VRYIKTTANATVDHLSKY 370
                    .|..|      ||||||:|||        |:....|.| .||:|||.||||||||||
Human   256 --------PEPGG------EIELVFRPHP--------LLVEKGEYCQTRYVKTTGNATVDHLSKY 298

  Fly   371 LAMRLTLDL---------------------------------GADLP--------EACRVLNFCI 394
            ||:|:.|:.                                 |.|.|        |......:.|
Human   299 LALRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQYTI 363

  Fly   395 YVAPQPQQLVILNGNQTLHQVNDKFWKVNKPMEMYYS 431
            |:||.......|||:.||..||:|||||::|:|:.|:
Human   364 YIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYA 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SceNP_477509.1 COG5222 <10..154 CDD:227547 113/143 (79%)
RING_Ubox 41..110 CDD:473075 65/68 (96%)
RAWUL_RING1_like 326..431 CDD:340606 53/146 (36%)
RING1NP_002922.2 Necessary for transcriptional repression. /evidence=ECO:0000250 30..234 121/231 (52%)
RING-HC_RING2 34..110 CDD:438398 72/75 (96%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 148..263 36/198 (18%)
Nuclear localization signal. /evidence=ECO:0000255 201..204 0/2 (0%)
Necessary for interaction with CBX2. /evidence=ECO:0000250 230..406 64/235 (27%)
RAWUL_RING1 261..400 CDD:340686 53/146 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 309..354 3/44 (7%)

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