DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sce and lnx2b

DIOPT Version :9

Sequence 1:	NP_477509.1	Gene:	Sce / 43327	FlyBaseID:	FBgn0003330	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	380	Identity:	87/380 - (22%)
Similarity:	126/380 - (33%)	Gaps:	100/380 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ELMCPICLDMLKKTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRADPNFDLLISK 107
            ||:|.|||..|.:.|.| .|.|.:|..|:...|.. ...||..|:: :..:..||.   .||:..
Zfish    43 ELVCHICLQPLLQPMDT-PCGHTYCFQCLSNFLHD-QDFCPVDRQR-IQLQQCRAS---SLLVRN 101

  Fly   108 IY-------PSREEYEAIQEKVMAKFNQTQSQQALVNSINEGIKLQSQ----NRPQRFRTKGGGG 161
            :.       |.|.|.|...::       .:.|..|.|......:|:.:    .||.....||...
Zfish   102 LLDKLAVLCPFRSECELSMQR-------CELQPHLHNRCPAFKRLREEAERKKRPSWNELKGSKS 159

  Fly   162 GGG-----GGGNGNGAANVAAPPAPGAPTAVGRNASNQMHVHDT---ASNDSNSNTNSIDRENRD 218
            .|.     ........|.::||..||..     |.:.:....||   .|..:.:....:.||  |
Zfish   160 DGDLADAKSAQTIGRTAQLSAPSEPGLV-----NPAFEEGEDDTPLRCSLVAEATVVELFRE--D 217

  Fly   219 PGHS-------------GTSAASAITSASNAAPSSSANSG-----------ASTSATR------- 252
            ||..             |......|...|..|.......|           ||.|.:|
Zfish   218 PGEDLGLRIVGGKDTPLGNIVIQEIVRDSLVARDGKLAPGDHILEVNDVSLASISHSRAIAVIRQ 282

  Fly   253 ---------MQVDDASNPPSVRSTPSPVPSNSSSSKPKR-----AMSVLTSERSE--------ES 295
                     ||.......|...:.||..|...|.|..:.     .::::..||||        :|
Zfish   283 PCSRLRLTVMQEKGFKPRPEHHTQPSASPPTQSPSTNQNHGTVIQVTLVKHERSEALGIKLIRKS 347

  Fly   296 ESDSQ--MDCRTEGDSNIDTEGEGNGE-LGINDEIELVFKPHPTEMSADNQLIRA 347
            |....  :|....|.:..|.:...|.: ||||.: :|   .|.|..|| .|:|:|
Zfish   348 EEPGVFILDLLPGGLAAKDGKLRNNDKVLGINGQ-DL---RHGTPESA-AQIIQA 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sce	NP_477509.1	RING	45..89	CDD:238093	15/43 (35%)
Sce	NP_477509.1	RAWUL	336..431	CDD:292824	6/12 (50%)
lnx2b	NP_998105.2	RING	46..82	CDD:214546	13/37 (35%)
		PDZ_signaling	210..291	CDD:238492	14/82 (17%)
		PDZ_signaling	325..406	CDD:238492	22/78 (28%)
		PDZ_signaling	451..537	CDD:238492
		PDZ_signaling	587..671	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030