DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sce and rnf2

DIOPT Version :9

Sequence 1:	NP_477509.1	Gene:	Sce / 43327	FlyBaseID:	FBgn0003330	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_571288.2	Gene:	rnf2 / 327035	ZFINID:	ZDB-GENE-030131-5243	Length:	338	Species:	Danio rerio

Alignment Length:	437	Identity:	193/437 - (44%)
Similarity:	237/437 - (54%)	Gaps:	134/437 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NKTWELSLYELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCSDCIVT 73
            :||||||||||||.|||.|||..|||||||||||||||||||||||.||||||||||||:|||:|
Zfish    16 SKTWELSLYELQRTPQEAITDGLEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIIT 80

  Fly    74 ALRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQTQSQQALVNS 138
            |||||||||||||||||||||||.|||||.|||||||||:||||.||:|:|:.::..:||||.:|
Zfish    81 ALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARISKHNNQQALSHS 145

  Fly   139 INEGIKLQSQNRPQRFRTKGGGGGGGGGGNGNGAANVAAPPAPGAPTAVGRNASNQMHVHDTASN 203
            |.||:|:|:.||.||       |......||:||
Zfish   146 IEEGLKIQAMNRLQR-------GKKHQIENGSGA------------------------------- 172

  Fly   204 DSNSNTNSIDRENRDPGHSGTSAASAITSASNAAPSSSANSGASTSATRMQVDDASNPPSVRSTP 268
                      .:|.|..|           .|||:..|:..:|                ||::.|
Zfish   173 ----------EDNGDSSH-----------CSNASVHSNQEAG----------------PSIKRT- 199

  Fly   269 SPVPSNSSSSKPKRAMSVLTSERSEESESDSQMDCRTEGDSNIDTEG---EGNGELGIN--DEIE 328
                                               :|..||.:|.:.   .|.|::.::  .|||
Zfish   200 -----------------------------------KTSDDSGLDMDNATENGGGDIALDGVSEIE 229

  Fly   329 LVFKPHPTEMSADNQLIRALKENC--VRYIKTTANATVDHLSKYLAMRLTLD----LGADLP--- 384
            |||:||||.|.         ||:.  .|||||:.||||||||||||:||.|:    .|...|
Zfish   230 LVFRPHPTLME---------KEDAAQTRYIKTSGNATVDHLSKYLAVRLALEEMRKNGEASPINV 285

  Fly   385 EACRVLNFCIYVAPQPQQLVILNGNQTLHQVNDKFWKVNKPMEMYYS 431
            ||.....:.||:.....|..:|||:.:|..|::|:||||||||:|::
Zfish   286 EAASEKQYTIYIPTASNQFTVLNGSFSLELVSEKYWKVNKPMELYFA 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sce	NP_477509.1	RING	45..89	CDD:238093	40/43 (93%)
Sce	NP_477509.1	RAWUL	336..431	CDD:292824	46/103 (45%)
rnf2	NP_571288.2	zf-C3HC4	53..92	CDD:278524	35/38 (92%)
rnf2	NP_571288.2	RAWUL	239..332	CDD:292824	45/101 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4899
eggNOG	1	0.900	-	-		E1_KOG0311
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2199
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2246
OMA	1	1.010	-	-		QHG48576
OrthoDB	1	1.010	-	-		D1319463at2759
OrthoFinder	1	1.000	-	-		FOG0003138
OrthoInspector	1	1.000	-	-		oto40570
orthoMCL	1	0.900	-	-		OOG6_105342
Panther	1	1.100	-	-	LDO	PTHR46076
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	1	1.000	-	-		X2531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870