DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sce and Rnf2

DIOPT Version :9

Sequence 1:	NP_477509.1	Gene:	Sce / 43327	FlyBaseID:	FBgn0003330	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	XP_006250052.1	Gene:	Rnf2 / 304850	RGDID:	1305491	Length:	336	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	189/430 - (43%)
Similarity:	240/430 - (55%)	Gaps:	120/430 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NKTWELSLYELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCSDCIVT 73
            :||||||||||||.|||.|||..||.||||||||||||||||||||.||||||||||||:|||:|
  Rat    14 SKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIIT 78

  Fly    74 ALRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQTQSQQALVNS 138
            |||||||||||||||||||||||.|||||.|||||||||:||||.||:|:|:.|:..:||||.:|
  Rat    79 ALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHS 143

  Fly   139 INEGIKLQSQNRPQRFRTKGGGGGGGGGGNGNGAANVAAPPAPGAPTAVGRNASNQMHVHDTASN 203
            |.||:|:|:.||.||.:.:....|.|...||:                              :|:
  Rat   144 IEEGLKIQAMNRLQRGKKQQIENGSGAEDNGD------------------------------SSH 178

  Fly   204 DSNSNTNSIDRENRDPGHSGTSAASAITSASNAAPSSSANSGASTSATRMQVDDASNPPSVRSTP 268
            .||::|:|    |::.|            .||....:|.:||       :::|:.:...::
  Rat   179 CSNASTHS----NQEAG------------PSNKRTKTSDDSG-------LELDNNNAAVAI---- 216

  Fly   269 SPVPSNSSSSKPKRAMSVLTSERSEESESDSQMDCRTEGDSNIDTEGEGNGELGINDEIELVFKP 333
            .||...:|                                                 ||||||:|
  Rat   217 DPVMDGAS-------------------------------------------------EIELVFRP 232

  Fly   334 HPTEMSADNQLIRALKENCVRYIKTTANATVDHLSKYLAMRLTLDLGADLPEACRV-------LN 391
            |||.|..|:..       ..|||||:.||||||||||||:||.|:......|:.::       ..
  Rat   233 HPTLMEKDDSA-------QTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQ 290

  Fly   392 FCIYVAPQPQQLVILNGNQTLHQVNDKFWKVNKPMEMYYS 431
            :.||:|....|..:|||:.:|..|::|:||||||||:||:
  Rat   291 YTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYA 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sce	NP_477509.1	RING	45..89	CDD:238093	40/43 (93%)
Sce	NP_477509.1	RAWUL	336..431	CDD:292824	43/101 (43%)
Rnf2	XP_006250052.1	COG5222	<11..>103	CDD:227547	79/88 (90%)
		RING-HC_RING1_like	51..91	CDD:319445	36/39 (92%)
		RAWUL_RING2	225..330	CDD:340687	52/111 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4772
eggNOG	1	0.900	-	-		E1_KOG0311
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2199
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2489
OMA	1	1.010	-	-		QHG48576
OrthoDB	1	1.010	-	-		D1319463at2759
OrthoFinder	1	1.000	-	-		FOG0003138
OrthoInspector	1	1.000	-	-		otm45446
orthoMCL	1	0.900	-	-		OOG6_105342
Panther	1	1.100	-	-	LDO	PTHR46076
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2531
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880