DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sce and spat-3

DIOPT Version :9

Sequence 1:	NP_477509.1	Gene:	Sce / 43327	FlyBaseID:	FBgn0003330	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001024904.2	Gene:	spat-3 / 259704	WormBaseID:	WBGene00020496	Length:	2476	Species:	Caenorhabditis elegans

Alignment Length:	366	Identity:	92/366 - (25%)
Similarity:	140/366 - (38%)	Gaps:	95/366 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LDPAPNKTWELSL--YELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRF 66
            ::||..:..||:|  |:..|....|:...:......:.:.....|.:|.::::.::.||:|.|||
Worm   118 MNPARMEGRELTLNAYDAVRNKYNVLPGKSVCEADLQKVIGSFSCDVCQELIQGSIMTKKCGHRF 182

  Fly    67 CSDCIVTA-LRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQTQ 130
            |..||:.| :|||| .|||||:.|.|||.|:.||.||.||.::..||    :|..::||
Worm   183 CDQCILVAFMRSGN-TCPTCRQNLGSKRELQQDPRFDQLIYQVVESR----SIVGRMMA------ 236

  Fly   131 SQQALVNSINEGIKLQSQNRPQR----FRTKGGGGGGGGGGNGNGAANVAAPPAPGAPTAVGRNA 191
                             :||...    |..||...||.......|....:...||....:.||..
Worm   237 -----------------ENREHEKDVYFGRKGYIEGGSDWNKRYGIDPNSKLKAPRPLKSAGRKK 284

  Fly   192 SNQMHVHDT-------------ASNDSNSNTNSIDRENRDPGHSGTSAASAITSASNAAPSSSAN 243
            ....|..|.             |..:.::|....|:|       |||.         ||......
Worm   285 IRWFHESDEDGSVRKVMESKKGAPKEDDTNYLENDKE-------GTSV---------AAEKEVLE 333

  Fly   244 SG--------ASTSATRMQVDDASNPPSVRSTPSPVPSNSSSSKPKRAMSVLTSERSEESESDSQ 300
            .|        .|:...:..:||...  |:..:...:..|...|||..:.|..|:.||.:| |:|.
Worm   334 EGEMDFPIEIKSSDEEQTDLDDEEE--SMLDSDFEISDNEDVSKPSCSTSKKTTNRSRDS-SESD 395

  Fly   301 MDCR------------------TEGD--SNIDTEGEGNGEL 321
            .|.|                  |:|.  ||...:.:.:||:
Worm   396 NDSRDNELQKKKRKMKRKNVPKTDGSDVSNESFDEDASGEV 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sce	NP_477509.1	RING	45..89	CDD:238093	21/44 (48%)
Sce	NP_477509.1	RAWUL	336..431	CDD:292824
spat-3	NP_001024904.2	RING-HC_RNF138	158..203	CDD:319458	20/45 (44%)
		MSCRAMM_SdrD	<290..583	CDD:380149	34/166 (20%)
		GREB1	<1301..>1430	CDD:374106
		PAT1	<1724..>1845	CDD:370676
		DUF1720	2150..>2199	CDD:369766
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I7962
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5327
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D462828at33208
OrthoFinder	1	1.000	-	-		FOG0003138
OrthoInspector	1	1.000	-	-		oto19476
orthoMCL	1	0.900	-	-		OOG6_105342
Panther	1	1.100	-	-	LDO	PTHR46076
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.990