DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sce and Rnf2

DIOPT Version :9

Sequence 1:	NP_477509.1	Gene:	Sce / 43327	FlyBaseID:	FBgn0003330	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001347773.1	Gene:	Rnf2 / 19821	MGIID:	1101759	Length:	345	Species:	Mus musculus

Alignment Length:	430	Identity:	189/430 - (43%)
Similarity:	240/430 - (55%)	Gaps:	120/430 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NKTWELSLYELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCSDCIVT 73
            :||||||||||||.|||.|||..||.||||||||||||||||||||.||||||||||||:|||:|
Mouse    23 SKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIIT 87

  Fly    74 ALRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQTQSQQALVNS 138
            |||||||||||||||||||||||.|||||.|||||||||:||||.||:|:|:.|:..:||||.:|
Mouse    88 ALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHS 152

  Fly   139 INEGIKLQSQNRPQRFRTKGGGGGGGGGGNGNGAANVAAPPAPGAPTAVGRNASNQMHVHDTASN 203
            |.||:|:|:.||.||.:.:....|.|...||:                              :|:
Mouse   153 IEEGLKIQAMNRLQRGKKQQIENGSGAEDNGD------------------------------SSH 187

  Fly   204 DSNSNTNSIDRENRDPGHSGTSAASAITSASNAAPSSSANSGASTSATRMQVDDASNPPSVRSTP 268
            .||::|:|    |::.|            .||....:|.:||       :::|:.:...::
Mouse   188 CSNASTHS----NQEAG------------PSNKRTKTSDDSG-------LELDNNNAAVAI---- 225

  Fly   269 SPVPSNSSSSKPKRAMSVLTSERSEESESDSQMDCRTEGDSNIDTEGEGNGELGINDEIELVFKP 333
            .||...:|                                                 ||||||:|
Mouse   226 DPVMDGAS-------------------------------------------------EIELVFRP 241

  Fly   334 HPTEMSADNQLIRALKENCVRYIKTTANATVDHLSKYLAMRLTLDLGADLPEACRV-------LN 391
            |||.|..|:..       ..|||||:.||||||||||||:||.|:......|:.::       ..
Mouse   242 HPTLMEKDDSA-------QTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQ 299

  Fly   392 FCIYVAPQPQQLVILNGNQTLHQVNDKFWKVNKPMEMYYS 431
            :.||:|....|..:|||:.:|..|::|:||||||||:||:
Mouse   300 YTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYA 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sce	NP_477509.1	RING	45..89	CDD:238093	40/43 (93%)
Sce	NP_477509.1	RAWUL	336..431	CDD:292824	43/101 (43%)
Rnf2	NP_001347773.1	RING-HC_RING2	56..102	CDD:319654	42/45 (93%)
		RING-HC finger (C3HC4-type)	60..99	CDD:319654	35/38 (92%)
		RAWUL_RING2	234..339	CDD:340687	52/111 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4874
eggNOG	1	0.900	-	-		E1_KOG0311
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2199
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2268
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48576
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003138
OrthoInspector	1	1.000	-	-		otm43376
orthoMCL	1	0.900	-	-		OOG6_105342
Panther	1	1.100	-	-	LDO	PTHR46076
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	1	1.000	-	-		X2531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860