Protein Alignment Sce and Brca1

DIOPT Version :9

• Sequence 1: NP_477509.1
• Gene: Sce / 43327
• FlyBaseID: FBgn0003330
• Length: 435
• Species: Drosophila melanogaster
• Sequence 2: NP_033894.3
• Gene: Brca1 / 12189
• MGIID: 104537
• Length: 1812
• Species: Mus musculus
• Alignment Length: 419
• Identity: 85/419 - (20%)
• Similarity: 148/419 - (35%)
• Gaps: 155/419 - (36%)

  Fly    13 ELSLYELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCSDCIVTAL-- 75
            :||..::| :.|.|:          .::...|.|||||:::|:.::|| |.|.||..|::..|
Mouse     2 DLSAVQIQ-EVQNVL----------HAMQKILECPICLELIKEPVSTK-CDHIFCKFCMLKLLNQ 54

  Fly    76 RSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQTQSQQALVNSIN 140
            :.|..:||.|:.: ::||||:....|..|..::.           ::||.|           .::
Mouse    55 KKGPSQCPLCKNE-ITKRSLQGSTRFSQLAEELL-----------RIMAAF-----------ELD 96

  Fly   141 EGIKLQSQNRPQRFRTKGGGGGGGGGGNGNGAANVAAPPAPGAPTAVGRNASNQMHVHDTASNDS 205
            .|::|.                       ||                              .:.|
Mouse    97 TGMQLT-----------------------NG------------------------------FSFS 108

  Fly   206 NSNTNSIDRENRDPGHSGTSAASAITSAS-----NAAPSSSANSGASTSATRMQVDDASNPPSVR 265
            ....||.:|.|.:        ||.|.|..     ...|.....:.....:..:|:   ||...||
Mouse   109 KKRNNSCERLNEE--------ASIIQSVGYRNRVRRLPQVEPGNATLKDSLGVQL---SNLGIVR 162

  Fly   266 STPSPVPSNSSSSKPKRAMSV-LTSERSEESESDSQMDCRTEGDSNIDTEGEGNGELGINDEIEL 329
            |    |..|..:...|:::.: |.|:.|||:.: ...||.......:.|..:..|:.|
Mouse   163 S----VKKNRQTQPRKKSVYIELDSDSSEETVT-KPGDCSVRDQELLQTAPQEAGDEG------- 215

  Fly   330 VFKPHPTEMSA--DNQLIRALKEN-CVRYIKTTAN-ATVDHLSKYLAMRLTLDLGADLPEACR-- 388
              |.|..|.:|  .::.||.::.: |...:..|.| ||..|                 ||.|:
Mouse   216 --KLHSAEEAACEFSEGIRNIEHHQCSDDLNPTENHATERH-----------------PEKCQSI 261

  Fly   389 -VLNFCI----------YVAPQPQQLVIL 406
             :.|.|:          .:.|:...|:::
Mouse   262 SISNVCVEPCGTDAHASSLQPETSSLLLI 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sce	NP_477509.1	RING	45..89	CDD:238093	18/45 (40%)
		RAWUL	336..431	CDD:292824	17/88 (19%)
Brca1	NP_033894.3	rad18	15..>172	CDD:273165	50/258 (19%)
		RING-HC_BRCA1	18..65	CDD:319412	18/47 (38%)
		RING-HC finger (C3HC4-type)	24..64	CDD:319412	17/40 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..198		9/33 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	321..362
		BRCT_assoc	342..503	CDD:372330
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..581
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..767
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	864..899
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..995
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1030..1056
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1147..1185
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1205..1230
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1244..1289
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1313..1343
		Interaction with PALB2. /evidence=ECO:0000250	1353..1380
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1437..1547
		BRCT_BRCA1_rpt1	1593..1689	CDD:349367
		BRCT_BRCA1_rpt2	1700..1797	CDD:349353

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030