Protein Alignment Hsdl2 and Hsd17b4

DIOPT Version :10

• Sequence 1: NP_651578.1
• Gene: Hsdl2 / 43325
• FlyBaseID: FBgn0039537
• Length: 412
• Species: Drosophila melanogaster
• Sequence 2: NP_077368.2
• Gene: Hsd17b4 / 79244
• RGDID: 621806
• Length: 735
• Species: Rattus norvegicus
• Alignment Length: 735
• Identity: 125/735 - (17%)
• Similarity: 216/735 - (29%)
• Gaps: 350/735 - (47%)

  Fly     9 GRTLFITGASRGIGKEIALKAARDGANIVV---------AAKTAEPHPKLPGTIYSAAEEIEKAG 64
            ||.:.:|||..|:|:..||..|..||.:||         ..|.:....|:       .|||.:.|
  Rat     9 GRVVLVTGAGGGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSSAADKV-------VEEIRRRG 66

  Fly    65 GKAYPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAI---SLTNTPDTDMKRYDLMHNINTR 126
            |||   |.:....:.....|:.|:..||.||:|:|||..:   |.:...|.|   :|::..::.|
  Rat    67 GKA---VANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDED---WDIIQRVHLR 125

  Fly   127 GTFLVSKVCLPYLKKSNHAHIL------------------------------------------- 148
            |:|.|::....::||.|:..|:
  Rat   126 GSFQVTRAAWDHMKKQNYGRIIMTASASGIYGNFGQANYSAAKLGLLGLANTLVIEGRKNNIHCN 190

  Fly   149 NISPPL---------------SMKPKWFGP----------------------------------- 163
            .|:|..               ::||::..|
  Rat   191 TIAPNAGSRMTETVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGA 255

  Fly   164 -----------------------------------------HVAYTMAKYGMS------------ 175
                                                     .|.:.:...|:|
  Rat   256 IVRKRNQPMTPEAVRDNWVKICDFSNASKPKSIQESTGGIIEVLHKIDSEGISQNHTGQVASADA 320

  Fly   176 ------------------------MCVLGMAAEFKD--------EGISVNALWPRTAIHTAAIEM 208
                                    |..||:.|..|:        ||.:..:..|...:..|...:
  Rat   321 SGFAGVVGHKLPSFSSSYTELQCIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSL 385

  Fly   209 LTG-----PD-SAKWSR-----------KP----------EIMAD-------------------- 226
            ::|     |. |..:::           ||          .::||
  Rat   386 MSGGLAEVPGLSINFAKVLHGEQYLELYKPLPRSGELKCEAVIADILDKGSGIVIVMDVYSYSGK 450

  Fly   227 ----------------------------AAYAILTREP----RQST--------------GQFFV 245
                                        ||.|:.:|.|    |.:|              ....:
  Rat   451 ELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPSRPPDAVLRDTTSLNQAALYRLSGDSNPLHI 515

  Fly   246 DDEVLESAGI------------------------TDLTEYACFR------------------ENA 268
            |......||.                        .|::.:...:                  :..
  Rat   516 DPSFASIAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEG 580

  Fly   269 DKLMVDFFVEEKGAPVENEAAAE-------DAAAPASGGDVKIPQLFRKIESLLSP---EIVSKT 323
            :::.....|:|.|..|.:.|..:       .|..|:.||.::...:|.:|...|..   |:|.|.
  Rat   581 NRIHFQTKVQETGDIVISNAYVDLVPTSGVSAQTPSEGGALQSALVFGEIGRRLKDVGREVVKKV 645

  Fly   324 QAVFQFNI--SGAEQGTWFLDLKNGSGSCGAGTPTAAPDATLTMNSKNFFDMFSGKLKAAPAYMT 386
            .|||:::|  :|.....|.:|||||||....|....:.|.|:|::.::|.::..|||....|:.:
  Rat   646 NAVFEWHITKNGNVAAKWTIDLKNGSGEVYQGPAKGSADTTITISDEDFMEVVLGKLNPQNAFFS 710

  Fly   387 GKLKISGDFQKALKLEKLMK 406
            |:||..|:...:.||:.::|
  Rat   711 GRLKARGNIMLSQKLQMILK 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsdl2	NP_651578.1	PRK08278	7..277	CDD:181349	81/592 (14%)
		SCP2	306..408	CDD:442486	35/106 (33%)
Hsd17b4	NP_077368.2	(3R)-hydroxyacyl-CoA dehydrogenase	1..305		52/308 (17%)
		hydroxyacyl-CoA-like_DH_SDR_c-like	5..254	CDD:187611	51/257 (20%)
		Enoyl-CoA hydratase 2	321..621		36/299 (12%)
		PLN02864	326..604	CDD:178455	32/277 (12%)
		SCP2	627..730	CDD:460423	34/102 (33%)
		Microbody targeting signal. /evidence=ECO:0000255	733..735