DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5590 and BDH2

DIOPT Version :9

Sequence 1:	NP_651578.1	Gene:	CG5590 / 43325	FlyBaseID:	FBgn0039537	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	XP_006714337.1	Gene:	BDH2 / 56898	HGNCID:	32389	Length:	259	Species:	Homo sapiens

Alignment Length:	286	Identity:	69/286 - (24%)
Similarity:	116/286 - (40%)	Gaps:	74/286 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GKLAGRTLFITGASRGIGKEIALKAARDGANIVVAAKTAEPHPKLPGTIYSAAEEIEKAGGKAYP 69
            |:|.|:.:.:|.|::|||:..||..||:||. |:|....|          |..:|:||     ||
Human     2 GRLDGKVIILTAAAQGIGQAAALAFAREGAK-VIATDINE----------SKLQELEK-----YP 50

  Fly    70 ----CVVDVRDEQQV---RSAVEAAVAKFGGIDIVINNASAISLTNTPDTDMKRYDLMHNINTRG 127
                .|:||..::|:   .:.||.       :|::.|.|..:......|.:.|.:|...|:|.|.
Human    51 GIQTRVLDVTKKKQIDQFANEVER-------LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRS 108

  Fly   128 TFLVSKVCLPYLKKSNHAHILNIS------------------PPLSMKPKWFGPHVAYTMAKYGM 174
            .:|:.|..||.:......:|:|:|                  |.|.:..:     ..|:..|..:
Human   109 MYLMIKAFLPKMLAQKSGNIINMSSVASSVKVMATDDEKLRLPMLRVVNR-----CVYSTTKAAV 168

  Fly   175 SMCVLGMAAEFKDEGISVNALWPRTAIHTAAIEMLTGPDSAKWSRKPEIMADAAYAILTREPRQS 239
            ......:||:|..:||..|.:.|.|....:..|.:....:.:.:|...:            .||.
Human   169 IGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFL------------KRQK 221

  Fly   240 TGQFFVDDEVL---------ESAGIT 256
            ||:|...:|:.         |||.:|
Human   222 TGRFATAEEIAMLCVYLASDESAYVT 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5590	NP_651578.1	FabG	5..245	CDD:223959	64/264 (24%)
		PRK08278	7..277	CDD:181349	68/284 (24%)
		SCP2	317..406	CDD:280250
BDH2	XP_006714337.1	DHRS6_like_SDR_c	5..259	CDD:187626	67/283 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0725
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810