DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5590 and HSD17B14

DIOPT Version :9

Sequence 1:	NP_651578.1	Gene:	CG5590 / 43325	FlyBaseID:	FBgn0039537	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_057330.2	Gene:	HSD17B14 / 51171	HGNCID:	23238	Length:	270	Species:	Homo sapiens

Alignment Length:	284	Identity:	72/284 - (25%)
Similarity:	114/284 - (40%)	Gaps:	55/284 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TG-KLAGRTLFITGASRGIGKEIALKAARDGANIVVAAKTAEP----HPKLPGTIYSAAEEIEKA 63
            || :.||:.:.:||..||||..|.......||.:|:..|....    ..:|||.::
Human     3 TGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVF--------- 58

  Fly    64 GGKAYPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAISLTNTP-DTDMKRYDLMHNINTRG 127
                  .:.||..|..|::.|...:.:||.:|.|:|||........| :|..:.:..:..:|..|
Human    59 ------ILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLG 117

  Fly   128 TFLVSKVCLPYLKKSNHAHILNISPPLSMKPKWFGPHVAYTMAKYGMSMCVLGMAAEFKDEGISV 192
            |:.::|:.||||:|| ..:::|||..:....:  ...|.|...|..::.....:|.:....|:.|
Human   118 TYTLTKLALPYLRKS-QGNVINISSLVGAIGQ--AQAVPYVATKGAVTAMTKALALDESPYGVRV 179

  Fly   193 NA---------LW---------PRTAIHTAAIEMLTGPDSAKWSRKPEIMADAAYAILTREPRQS 239
            |.         ||         ||..|...   ||..| ..:..:..|:.|.|.:  |..|....
Human   180 NCISPGNIWTPLWEELAALMPDPRATIREG---MLAQP-LGRMGQPAEVGAAAVF--LASEANFC 238

  Fly   240 TGQFFVDDEVLESAGITDLTEYAC 263
            ||     .|:|.:.|..  ..|.|
Human   239 TG-----IELLVTGGAE--LGYGC 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5590	NP_651578.1	FabG	5..245	CDD:223959	66/263 (25%)
		PRK08278	7..277	CDD:181349	70/280 (25%)
		SCP2	317..406	CDD:280250
HSD17B14	NP_057330.2	RDH_SDR_c	1..256	CDD:187638	72/284 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0725
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900