DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5590 and dhs-6

DIOPT Version :9

Sequence 1:	NP_651578.1	Gene:	CG5590 / 43325	FlyBaseID:	FBgn0039537	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001021972.1	Gene:	dhs-6 / 3565470	WormBaseID:	WBGene00000970	Length:	418	Species:	Caenorhabditis elegans

Alignment Length:	417	Identity:	231/417 - (55%)
Similarity:	291/417 - (69%)	Gaps:	17/417 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MINTGKLAGRTLFITGASRGIGKEIALKAARDGANIVVAAKTAEPHPKLPGTIYSAAEEIEKAGG 65
            |.||||..|||:.|||||||||||||||.|:||||||||||||..||||||||||||||||||||
Worm     1 MFNTGKFVGRTVLITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYSAAEEIEKAGG 65

  Fly    66 KAYPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAISLTNTPDTDMKRYDLMHNINTRGTFL 130
            ||.||:||||||..|:::||.||.|||||||:||||||||||:|.:|:||||||||:||||||||
Worm    66 KALPCIVDVRDEASVKASVEEAVKKFGGIDILINNASAISLTDTENTEMKRYDLMHSINTRGTFL 130

  Fly   131 VSKVCLPYLKKSNHAHILNISPPLSMKPKWFGPHVAYTMAKYGMSMCVLGMAAEFKDEGISVNAL 195
            ::|.||||||...:.|:|||||||.|:.:||..|||||||||||||||||...||:..||:||||
Worm   131 MTKTCLPYLKSGKNPHVLNISPPLLMETRWFANHVAYTMAKYGMSMCVLGQHEEFRPHGIAVNAL 195

  Fly   196 WPRTAIHTAAIEMLTGPDSAKWSRKPEIMADAAYAILTREPRQSTGQFFVDDEVLESAGITDLTE 260
            ||.|||.|||:|||:.......||||.||||||||:|::..:..||.|.:|:::|::.|:||...
Worm   196 WPLTAIWTAAMEMLSDKGGEAGSRKPSIMADAAYAVLSKNSKDFTGNFCIDEDILKAEGVTDFDR 260

  Fly   261 YACFRENADKLMVDFFVE--------EKGAPVENEAAAEDAAAPASGGDVKIPQLFRKIESLLSP 317
            |||..:  ..||.|||:.        ..||.:..:....:|...    :.:|.|:|...:.||:.
Worm   261 YACVPD--APLMPDFFIPAGTYDHKFSSGAQIGKKNKTHEAGVV----EEEIKQIFTSAKRLLNA 319

  Fly   318 EIVSKTQAVFQFNI---SGAEQGTWFLDLKNGSGSCGAGTPTAAPDATLTMNSKNFFDMFSGKLK 379
            :||.||..|::|.:   :...:....||||||.|:......:...|...|:..::|..:|:|||:
Worm   320 DIVKKTGFVYEFLLKDPTTKSERIITLDLKNGEGALTDKKASGKADVKFTLAPEHFAPLFTGKLR 384

  Fly   380 AAPAYMTGKLKISGDFQKALKLEKLMK 406
            ...|.||.||:||||...|:|||.|::
Worm   385 PTTALMTKKLQISGDMPGAMKLESLLR 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5590	NP_651578.1	FabG	5..245	CDD:223959	173/239 (72%)
		PRK08278	7..277	CDD:181349	183/269 (68%)
		SCP2	317..406	CDD:280250	34/91 (37%)
dhs-6	NP_001021972.1	PRK08278	9..275	CDD:181349	183/267 (69%)
dhs-6	NP_001021972.1	SCP2	319..411	CDD:376720	34/91 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156035
Domainoid	1	1.000	305	1.000	Domainoid score	I745
eggNOG	1	0.900	-	-		E1_KOG4170
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75204
Inparanoid	1	1.050	438	1.000	Inparanoid score	I939
Isobase	1	0.950	-	0	Normalized mean entropy	S1809
OMA	1	1.010	-	-		QHG63699
OrthoDB	1	1.010	-	-		D1361949at2759
OrthoFinder	1	1.000	-	-		FOG0005600
OrthoInspector	1	1.000	-	-		otm14130
orthoMCL	1	0.900	-	-		OOG6_103987
Panther	1	1.100	-	-	LDO	PTHR42808
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4574
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.760