Protein Alignment Hsdl2 and HSD17B4

DIOPT Version :10

• Sequence 1: NP_651578.1
• Gene: Hsdl2 / 43325
• FlyBaseID: FBgn0039537
• Length: 412
• Species: Drosophila melanogaster
• Sequence 2: NP_001186220.1
• Gene: HSD17B4 / 3295
• HGNCID: 5213
• Length: 761
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 113/687 - (16%)
• Similarity: 186/687 - (27%)
• Gaps: 353/687 - (51%)

  Fly    58 EEIEKAGGKAYPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAI---SLTNTPDTDMKRYDL 119
            |||.:.||||......|.:.::|   |:.|:..||.||:|:|||..:   |.....|.|   :|:
Human    85 EEIRRRGGKAVANYDSVEEGEKV---VKTALDAFGRIDVVVNNAGILRDRSFARISDED---WDI 143

  Fly   120 MHNINTRGTFLVSKVCLPYLKKSNHAHIL------------------------------------ 148
            :|.::.||:|.|::....::||..:..|:
Human   144 IHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGR 208

  Fly   149 -------NISPPL---------------SMKPK--------------------------WFG--- 162
                   .|:|..               ::||:                          |.|
Human   209 KSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLR 273

  Fly   163 ----------------------------------------------------------------- 162
                                                                             
Human   274 WERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHT 338

  Fly   163 -------------------PHVAYTMAKYGMSMCVLGMAAEFKD--------------------- 187
                               |..:|...:....|..||:.|..||
Human   339 SRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFG 403

  Fly   188 ----------------EGISVN------------------------------------------- 193
                            .|:|:|
Human   404 VIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIM 468

  Fly   194 ------------------------------------------------ALWPRTAIHTAAIEMLT 210
                                                            .|...|:::.||:..|:
Human   469 DVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLS 533

  Fly   211 G--------PDSAKWS--RKPEIMADAAYAILTREPRQSTGQFFVDDEVLESAGI---------- 255
            |        |:.|..:  .||.:.....:....|...|.    |.|::|.....|
Human   534 GDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQ----FADNDVSRFKAIKARFAKPVYP 594

  Fly   256 --TDLTEYACFRENADKLMVDFFVEEKGAPVENEAAAEDAAAPASGGDVKIPQLFRKIESL---- 314
              |..||   ..:..:::.....|:|.|..|.:.|..:  .||.||...|.|....|::|.
Human   595 GQTLQTE---MWKEGNRIHFQTKVQETGDIVISNAYVD--LAPTSGTSAKTPSEGGKLQSTFVFE 654

  Fly   315 --------LSPEIVSKTQAVFQFNIS-GAEQGT-WFLDLKNGSGSCGAGTPTAAPDATLTMNSKN 369
                    :.||:|.|..|||:::|: |...|. |.:|||:|||....|....|.|.|:.::.::
Human   655 EIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDED 719

  Fly   370 FFDMFSGKLKAAPAYMTGKLKISGDFQKALKLEKLMK 406
            |.::..|||....|:.:|:||..|:...:.||:.::|
Human   720 FMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILK 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsdl2	NP_651578.1	PRK08278	7..277	CDD:181349	67/542 (12%)
		SCP2	306..408	CDD:442486	35/115 (30%)
HSD17B4	NP_001186220.1	hydroxyacyl-CoA-like_DH_SDR_c-like	61..279	CDD:187611	37/199 (19%)
		PLN02864	353..630	CDD:178455	35/285 (12%)
		SCP2	653..756	CDD:460423	32/102 (31%)