DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5590 and hsdl2

DIOPT Version :9

Sequence 1:	NP_651578.1	Gene:	CG5590 / 43325	FlyBaseID:	FBgn0039537	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_955893.1	Gene:	hsdl2 / 322347	ZFINID:	ZDB-GENE-030131-1066	Length:	415	Species:	Danio rerio

Alignment Length:	418	Identity:	238/418 - (56%)
Similarity:	300/418 - (71%)	Gaps:	14/418 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NTGKLAGRTLFITGASRGIGKEIALKAARDGANIVVAAKTAEPHPKLPGTIYSAAEEIEKAGGKA 67
            |||||||.|:|||||||||||.||||||:||||:|:|||||:||||||||||:||.|||.|||||
Zfish     4 NTGKLAGCTIFITGASRGIGKAIALKAAQDGANVVIAAKTADPHPKLPGTIYTAAAEIEAAGGKA 68

  Fly    68 YPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAISLTNTPDTDMKRYDLMHNINTRGTFLVS 132
            .||:||||||:|:..|||.||.|||||||::||||||:||.|..|.||:.|||..||.|||:|.|
Zfish    69 LPCIVDVRDEKQINDAVEQAVEKFGGIDILVNNASAINLTGTLQTPMKKADLMLGINLRGTYLTS 133

  Fly   133 KVCLPYLKKSNHAHILNISPPLSMKPKWFGPHVAYTMAKYGMSMCVLGMAAEFKDEGISVNALWP 197
            |:|:|:|.||.:.||||:||||::.|.||..|.|||:|||||||||||||.||:. .|:||||||
Zfish   134 KLCIPHLLKSKNPHILNLSPPLNLNPIWFKNHTAYTIAKYGMSMCVLGMAEEFRG-SIAVNALWP 197

  Fly   198 RTAIHTAAIEMLTGPDSAKWSRKPEIMADAAYAILTREPRQSTGQFFVDDEVLESAGITDLTEYA 262
            :|||.|||::||.|.:..|..||.||||||||||. ::|...||||.:|:::|:..||.|...||
Zfish   198 KTAIQTAAMDMLGGSEVGKQCRKVEIMADAAYAIF-KQPTSFTGQFVIDEDILKKEGIKDFDVYA 261

  Fly   263 CFRENADKLMVDFFVEEKGAPVENEAAAEDA--------AAPASGGDVKIPQLFRKIESLLSPEI 319
            .  |....|:.|||::.:...:.....|..|        |.|.:.|.|.  ::|..|..::|||:
Zfish   262 V--EPGHPLLPDFFLDGQPEDLVKHMEAHGATPAFTTAKADPVAAGPVS--EMFNTIRGIISPEM 322

  Fly   320 VSKTQAVFQFNISGAEQGTWFLDLKNGSGSCGAGTPTAAPDATLTMNSKNFFDMFSGKLKAAPAY 384
            |..||.|::||::|...|.|:|||||.:||.|.|.|....|..::|:|::|..||.||||...|:
Zfish   323 VKTTQGVYKFNLAGEHAGVWYLDLKNDAGSAGNGEPPVKADVVMSMDSEDFVKMFGGKLKPTMAF 387

  Fly   385 MTGKLKISGDFQKALKLEKLMKALKSKL 412
            |:|||.|.||...|:||||:|..:||||
Zfish   388 MSGKLTIKGDMGLAIKLEKMMAMMKSKL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5590	NP_651578.1	FabG	5..245	CDD:223959	166/239 (69%)
		PRK08278	7..277	CDD:181349	175/269 (65%)
		SCP2	317..406	CDD:280250	44/88 (50%)
hsdl2	NP_955893.1	HSDL2_SDR_c	8..248	CDD:187663	165/241 (68%)
		adh_short	12..210	CDD:278532	141/198 (71%)
		SCP2	311..408	CDD:280250	47/96 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580484
Domainoid	1	1.000	276	1.000	Domainoid score	I1711
eggNOG	1	0.900	-	-		E1_KOG4170
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75204
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1543
OMA	1	1.010	-	-		QHG63699
OrthoDB	1	1.010	-	-		D1361949at2759
OrthoFinder	1	1.000	-	-		FOG0005600
OrthoInspector	1	1.000	-	-		oto40812
orthoMCL	1	0.900	-	-		OOG6_103987
Panther	1	1.100	-	-	LDO	PTHR42808
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5337
SonicParanoid	1	1.000	-	-		X4574
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800