DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5590 and DHRS4L2

DIOPT Version :9

Sequence 1:	NP_651578.1	Gene:	CG5590 / 43325	FlyBaseID:	FBgn0039537	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_932349.2	Gene:	DHRS4L2 / 317749	HGNCID:	19731	Length:	232	Species:	Homo sapiens

Alignment Length:	222	Identity:	52/222 - (23%)
Similarity:	93/222 - (41%)	Gaps:	19/222 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MINTGKLAGRTLFITGASRGIGKEIALKAARDGANIVVAAKTAEPHPKLPGTIYSAAEEIEKAGG 65
            |.....|..:...:|.::.|||..||.:.|:|.|::||:::..:       .:..|...::..|.
Human    24 MTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQ-------NVDQAVATLQGEGL 81

  Fly    66 KAYPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAISLTNT-PDTDMKRYDLMHNINTRGTF 129
            .....|..|...:.....|..||...|||||:::||:......: .|...:.:|...:||.:...
Human    82 SVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPA 146

  Fly   130 LVSKVCLPYLKKSNHAHILNISPPLSMKPK-WFGPHVAYTMAKYGMSMCVLGMAAEFKDEGISVN 193
            |::|..:|.::|.....::.:|...:..|. .|.|:.....|..|::..   :|.|.....|.||
Human   147 LMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNT---LAIELAPRNIRVN 208

  Fly   194 ALWPRTAIHTAAIEMLTGPDSAKWSRK 220
            .|      | ..:..|.....:.|:||
Human   209 CL------H-LDLSRLASAGCSGWTRK 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5590	NP_651578.1	FabG	5..245	CDD:223959	51/218 (23%)
		PRK08278	7..277	CDD:181349	51/216 (24%)
		SCP2	317..406	CDD:280250
DHRS4L2	NP_932349.2	NADB_Rossmann	24..>210	CDD:304358	46/195 (24%)
DHRS4L2	NP_932349.2	adh_short	33..210	CDD:278532	44/186 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0725
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810