DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtl and RHOBTB1

DIOPT Version :9

Sequence 1:	NP_524533.1	Gene:	Mtl / 43319	FlyBaseID:	FBgn0039532	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_001229288.1	Gene:	RHOBTB1 / 9886	HGNCID:	18738	Length:	696	Species:	Homo sapiens

Alignment Length:	215	Identity:	83/215 - (38%)
Similarity:	120/215 - (55%)	Gaps:	34/215 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTGRP----IKCVVVGDGTVGKTCMLISYTTDCFPGEY------VPTVF--DNYSAPMQ----- 48
            |...||    ||||||||..||||.::.:...:....:|      ||||:  |.|....:
Human     5 MDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERS 69

  Fly    49 ---VDTIQVSLGLWDTAGQEDYDRLRPLSYPQTDVFLICYSVASPSSFENVTSKWYPEIKHHCPD 110
               ||.:.|||.||||.|  |:.:.|..:|.::||.::|:|:|:|:|..:|.|.|||||||.||.
Human    70 RDVVDEVSVSLRLWDTFG--DHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKSMWYPEIKHFCPR 132

  Fly   111 APIILVGTKIDLR-EDRETLSGLAEQGLTPLKR------EQGQKLANKIRAVKYMECSALTQRGL 168
            .|:||||.::||| .|.|.::........|:||      |:|:::|.:: .:.|.|.|...|.|:
Human   133 TPVILVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKEL-GLPYYETSVFDQFGI 196

  Fly   169 KPVFEEAVRAVLRPEPLKRR 188
            |.||:.|:||.|    :.||
Human   197 KDVFDNAIRAAL----ISRR 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtl	NP_524533.1	RHO	9..182	CDD:197554	76/195 (39%)
RHOBTB1	NP_001229288.1	Rho-like	1..210		81/211 (38%)
		RhoBTB	13..207	CDD:133275	76/196 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..348
		BTB	<396..455	CDD:197585
		BTB	476..581	CDD:306997
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810