DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tusp and Wdr35

DIOPT Version :9

Sequence 1:	NP_001263014.1	Gene:	Tusp / 43317	FlyBaseID:	FBgn0039530	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_766058.3	Gene:	Wdr35 / 74682	MGIID:	1921932	Length:	1181	Species:	Mus musculus

Alignment Length:	371	Identity:	108/371 - (29%)
Similarity:	174/371 - (46%)	Gaps:	69/371 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NINTKCDCTILSLSWMGKVPDDIPEDEGWKLNRTNYYQEGWLATGNVRGIVGV----TFTTSHCR 68
            |:..||      :||                |:    .:|::|.|...|::.|    |.|.....
Mouse    14 NVKLKC------ISW----------------NK----DQGFIACGGEDGLLKVLRLETQTDDSKL 52

  Fly    69 KNMDYP--LRTNYNLRGHRSDVILVKWNEPYQKLASCDSSGIIFVWIKYEGRWSIELINDRNTPV 131
            :.:..|  |..|.||.||...|.:|.|||.||||.:.|.:|:|.||:.|:|.|..|:||:||..|
Mouse    53 RGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSV 117

  Fly   132 TH-FSWSHDGRMALICYQDGFVLVGSVAGQRYWSSMLNLESTITCGI-WTPDDQQVYFGTTQGQV 194
            .. .||:.||:...|.|:||.|:||||.|.|.|..  :|:....|.: |:.|.:.:.||...|::
Mouse   118 VRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGK--DLKGIQLCHVTWSADSKILLFGMANGEI 180

  Fly   195 IVMDVHGAMVSQVQLSNDVPITSMAWSCEKFKMEEGEE--AEPGVTNAAKRSFVLAVSFQNGYIY 257
            .:.|..|..:.:::|:..|.:|. |.|........|.|  .||...       .||:.|.||...
Mouse   181 HIYDNQGNFIMKMKLNCLVNVTG-AISIAGIHWYHGTEGYVEPDCP-------CLAICFDNGRCQ 237

  Fly   258 LLKSFDDVSPAHINTCLNGALGMVMEWSNSRELLAVAGTLRTGVDGTKTEDMGTPSCYTNLVKFY 322
            :::..:|.:|..|:|   |...:.::|::...:|||||:.:.   .|:.:|:       |:|:||
Mouse   238 IMRHENDQNPVLIDT---GMYVVGIQWNHIGSVLAVAGSQKV---VTQDKDI-------NIVQFY 289

  Fly   323 TETGTCLYQAHIP----CSSATVSAITWGHNDKRLFIATGTQVHIA 364
            |..|..|....:|    ||      ::|.....::.:|..:.::.|
Mouse   290 TPFGEHLGTLKVPGKQMCS------LSWEGGGLKIALAVDSFIYFA 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tusp	NP_001263014.1	WD40	51..>295	CDD:225201	83/253 (33%)
		WD40	81..359	CDD:295369	90/285 (32%)
		WD40 repeat	91..126	CDD:293791	18/34 (53%)
		WD40 repeat	132..168	CDD:293791	16/36 (44%)
		WD40 repeat	173..208	CDD:293791	8/35 (23%)
		WD40 repeat	216..263	CDD:293791	12/48 (25%)
		WD40 repeat	270..333	CDD:293791	18/62 (29%)
		Tub	<588..>644	CDD:279506
		Tub	<1355..1426	CDD:279506
Wdr35	NP_766058.3	WD40	<7..217	CDD:225201	74/231 (32%)
		WD 1	12..51		13/62 (21%)
		WD40 repeat	18..69	CDD:293791	17/76 (22%)
		WD 2	69..108		19/38 (50%)
		WD40 repeat	74..111	CDD:293791	18/36 (50%)
		WD 3	113..152		19/38 (50%)
		WD 4	154..193		9/38 (24%)
		WD40 repeat	205..251	CDD:293791	12/52 (23%)
		WD40 repeat	256..300	CDD:293791	15/53 (28%)
		WD40 repeat	308..345	CDD:293791	4/28 (14%)
		WD 5	502..539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810