Protein Alignment Tusp and TULP2

DIOPT Version :9

• Sequence 1: NP_001263014.1
• Gene: Tusp / 43317
• FlyBaseID: FBgn0039530
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_003314.2
• Gene: TULP2 / 7288
• HGNCID: 12424
• Length: 520
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 121/560 - (21%)
• Similarity: 207/560 - (36%)
• Gaps: 164/560 - (29%)

  Fly   973 ALSALRKDAPNKRLILVDKKRNRRKRQQQEDARRHKLQQTGKSKSLDSCDLLSLQTK-------- 1029
            |...|:|....:||.   :|:.|:|||                      :||.:|..
Human    18 AAMRLQKLEQQRRLF---EKKQRQKRQ----------------------ELLMVQANPDASPWLW 57

  Fly  1030 LSSKEHEQVV-----------RKLQEISDSSACSSAANTLCFKC-------------------RN 1064
            .|....|:::           :|:.|....|...||..|:  .|                   ||
Human    58 RSCLREERLLGDRGLGNPFLRKKVSEAHLPSGIHSALGTV--SCGGDGRGERGLPTPRTEAVFRN 120

  Fly  1065 NMSPSSACKRCQPSASSVLDEITAVVPAVEPA--KESPAV-----QAKPAPKKRFDVITSFTDSP 1122
            ....|........::.:.|:|::....:|.|.  |:||.:     ||...|..|.:
Human   121 LGLQSPFLSWLPDNSDAELEEVSVENGSVSPPPFKQSPRIRRKGWQAHQRPGTRAE--------- 176

  Fly  1123 LFTRKHRFGIGRS-KETAGTENSTPLLGRKQD-NGFSFVKQLSEVRWRRKEQPAQAQVNGSSNAS 1185
                      |.| .:..|..:.:|.:|.... :|....:.|:..:....|:..:|..:..:|:|
Human   177 ----------GESDSQDMGDAHKSPNMGPNPGMDGDCVYENLAFQKEEDLEKKREASESTGTNSS 231

  Fly  1186 TLERQPQPEITGAACGTVEATPVEAKASVSLHTQALTTLENIISRLRDLDEGRLTPPSTPQRLPR 1250
            ....:...:......|| ::..:..:||:::.:.. ..||      .|::...|.|     .||.
Human   232 AAHNEELSKALKGEGGT-DSDHMRHEASLAIRSPC-PGLE------EDMEAYVLRP-----ALPG 283

  Fly  1251 SSPASPAASKKNKRQQSNSPIRHI-------LNSPLL---NRRQRKKQSIIESSDDEGNQTNGS- 1304
            :.........|:...:...|:.::       |...||   .||:.|..:.:.|.|......:|.
Human   284 TMMQCYLTRDKHGVDKGLFPLYYLYLETSDSLQRFLLAGRKRRRSKTSNYLISLDPTHLSRDGDN 348

  Fly  1305 --GEESNNA--------GNG-KQYRDLETFQKAQLRQKLKRGKIEPN---------------GSA 1343
              |:..:|.        .|| ...|:..|...|::||:|.....|||               |:.
Human   349 FVGKVRSNVFSTKFTIFDNGVNPDREHLTRNTARIRQELGAVCYEPNVLGYLGPRKMTVILPGTN 413

  Fly  1344 S---CANPAPVRRE---------------FVMHNKAPMWNEMSQVYQLDFGGRVTQESAKNFQI- 1389
            |   ..|..|:..:               .::|||.|.|::.:.||.|:|.||||:.|.|||||
Human   414 SQNQRINVQPLNEQESLLSRYQRGDKQGLLLLHNKTPSWDKENGVYTLNFHGRVTRASVKNFQIV 478

  Fly  1390 --EFRGKQVMQFGRIDGNAYTLDFQYPFSALQAFAVALAN 1427
              :.:...|:||||:..:.:|:||.:|||.||||::.|::
Human   479 DPKHQEHLVLQFGRVGPDTFTMDFCFPFSPLQAFSICLSS 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tusp	NP_001263014.1	WD40	51..>295	CDD:225201
		WD40	81..359	CDD:295369
		WD40 repeat	91..126	CDD:293791
		WD40 repeat	132..168	CDD:293791
		WD40 repeat	173..208	CDD:293791
		WD40 repeat	216..263	CDD:293791
		WD40 repeat	270..333	CDD:293791
		Tub	<588..>644	CDD:279506
		Tub	<1355..1426	CDD:279506	34/73 (47%)
TULP2	NP_003314.2	Tub_N	27..241	CDD:318529	44/259 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	141..236		21/113 (19%)
		Tub	279..519	CDD:307359	66/245 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920