DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tusp and Tulp4

DIOPT Version :9

Sequence 1:	NP_001263014.1	Gene:	Tusp / 43317	FlyBaseID:	FBgn0039530	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	XP_006523311.1	Gene:	Tulp4 / 68842	MGIID:	1916092	Length:	1590	Species:	Mus musculus

Alignment Length:	1718	Identity:	544/1718 - (31%)
Similarity:	740/1718 - (43%)	Gaps:	439/1718 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DCTILSLSWMGKVPDDIPEDEGWKLNRTNYYQEGWLATGNVRGIVGVTFTTSHCRKNMDYPLRTN 78
            |..||.|||.|:||....|.   .:.|..||:||||||||.||:||||||:||||::...|.|.|
Mouse    14 DSNILCLSWKGRVPKSEKEK---PVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRIN 75

  Fly    79 YNLRGHRSDVILVKWNEPYQKLASCDSSGIIFVWIKYEGRWSIELINDRNTPVTHFSWSHDGRMA 143
            :|||||.|:|:||:|||||||||:||:.|.|||||:||||||:||:|||...|:.|:|||||..|
Mouse    76 FNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQA 140

  Fly   144 LICYQDGFVLVGSVAGQRYWSSMLNLESTITCGIWTPDDQQVYFGTTQGQVIVMDVHGAMVSQVQ 208
            ||.|:|||||||||:|||:|||.:||||.|||||||||||||.|||..|||||||.||.|::.|.
Mouse   141 LISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVL 205

  Fly   209 LSNDVPITSMAWSCEKFKMEEGEEAEPG-----------------VTNAAKRSFVLAVSFQNGYI 256
            |.....|.||:|:...|.:|:..|::..                 |.|...   :|.|||.:|.|
Mouse   206 LHESDGILSMSWNYPIFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNTKP---LLTVSFTSGDI 267

  Fly   257 YLLKSFDDVSPAHINTCLNGALGMVMEWSNSRELLAVAGTLRTGVDGTKTEDMGTPSCYTNLVKF 321
            .|:.::||:||..|.   :|...:|.:|....:||||||..:   ....:|....|...:.:|||
Mouse   268 SLMNNYDDLSPTVIR---SGLKEVVAQWCTQGDLLAVAGMEQ---QAQLSELPNGPLLKSAMVKF 326

  Fly   322 YTETGTCLYQAHIPCSSATVSAITWGHNDKRLFIATGTQVHIAWVSRRVASLQLLCRLEIQASVG 386
            |...|..::..........:| |.|||.|.||.:|:|..:::..|..||:||||||:..|.:::.
Mouse   327 YNVRGEHIFTLDTLVQRPIIS-ICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASTLR 390

  Fly   387 SESLLPLLPLPSRIKSLIGNLFAQTIRCCVPDLKSLRDFVSRPPLCSTRLHCTMIRHDDDSNLSS 451
            .:..:..|.||.|:.|.:...|..||:..:||..::|||||.|...:.||||||.|.:||..: .
Mouse   391 EDKDVNKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDDPEV-G 454

  Fly   452 GTCYTLYLEYLGGLVPLLKGKRTSKIRPEFVIFDPQVNDSPLYFQYSAEAKSSS--GSSQ-STTT 513
            |.||||||||||||||:|||:|.||:||||||.||:           .::||..  |:|. ||..
Mouse   455 GPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPR-----------TDSKSDEIYGNSLISTVI 508

  Fly   514 GNSGRTDSSDSDFEE-----------RSRFGSPRTPR---KKRVRPKRRHQAGD-----RLSASG 559
            .:...:||||.:..:           ||. .||:.||   :.|..||....|.:     ||....
Mouse   509 DSCNCSDSSDIELSDDWAAKKSPKISRSS-KSPKLPRISIEARKSPKLPRAAQEISRSPRLPMRK 572

  Fly   560 GGVSNDPDSLDELAYVDTLPEQEVKLVEVTSNIWGTKFKIHGLAKTVPANLGQ------------ 612
            ..:.:...:..|..:.|.  .|...|.:||||||||||||.|||..:|.|||.
Mouse   573 PSMGSPSLTRREFPFEDI--TQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAEANDACNHSSMQ 635

  Fly   613 -------------------------------VTYKTSLLHLQPRQMTLVITELRD---DFPPGPD 643
                                           |.||||||||||||||:.:.|:|.   |:.  ..
Mouse   636 KSNVLYCSGQYFCTNSEQHRTFPPTFRLCFVVIYKTSLLHLQPRQMTIYLPEVRKISMDYI--NL 698

  Fly   644 PSFNPNIFSEDEDEHHQHQGIHHDAVPQVNVITAQDGASLKPPIIPQRRLTDGASAPLIAPMSPR 708
            |.||||:||||||:           :|    :|...|       :|:.......:.| |||:
Mouse   699 PVFNPNVFSEDEDD-----------LP----VTGASG-------VPENNPPCTVNIP-IAPI--- 737

  Fly   709 PNRILARHKNSLTVNGERGSGSSAGLSPLARAESYDDDSSNESQEAGAAGSQSTTVLLHQAPSNG 773
                   |.::..::..:..|....|  ||......|..:|::...|:|.........:...|..
Mouse   738 -------HSSAQALSPTQSIGLVQSL--LANQNVQLDVLTNQTTAVGSAEHAGDAATQYPVSSRY 793

  Fly   774 SGPG----------------------PSCSKSITRPKTISSFKN-SYSRSSSNSSCQSRHAISPL 815
            |.||                      |........|..:|:..: .........|.::...:..|
Mouse   794 SNPGQVIFGGVEMGRIIQNPPQLPLPPPPPPPPQAPMQLSAVDHGDRDHEHLQKSAKALRPVPQL 858

  Fly   816 YCDG---------------------------AVPTLQSPKNAVAPS----DIIFER------PAV 843
            ..:|                           |.||..:|...:.|.    |:..::      |..
Mouse   859 AAEGDAVVFSAPQEVQVAKMNPPPPYPGTIPAAPTTAAPPPPLPPPQPPVDVCLKKGDFSLYPTA 923

  Fly   844 ----PAAGQTTLMSYSSNADYANNVVQVKNALMSEPVRSANSHVNPVP-LNLNLNLERMDARVKC 903
                |..|...:.::.|:.: ...|.:.:..::.    |.|::..|.| .:..|.|...:.:|
Mouse   924 AHYQPPLGYERITTFDSSGN-VEEVCRPRTRMLC----SQNTYTLPGPGSSATLRLTATEKKV-- 981

  Fly   904 TAPTTSSTAKRREMLYIDEETQSPTPTPSSSSMKRTPTVVSIAPALPDSITRSCSVGYLDSVAIT 968
            ..|.||:|..|..:......|..|.|.|            .||..|...  ||
Mouse   982 PQPCTSATLNRLTVPRYSIPTGDPPPYP------------EIASQLAQG--RS------------ 1020

  Fly   969 PSDEALSALRKDAPNKRLILVDKKRNRR----KRQQQEDARRHKLQQTGKSK------------- 1016
                  :|.|.|   ..||....:||.|    |..|..|:.|..||...|.|
Mouse  1021 ------AAQRLD---NSLIHATLRRNNREVALKMAQLADSSRAPLQPLAKPKGGAAGAVAQLPAR 1076

  Fly  1017 ---SLDSCDLLSLQTKLSSKEHEQVVRKLQEISDSSACSSAANTLCFKCRNNMSPSSACKRCQPS 1078
               :|.:|.    |...:....:........||.|...|.::..|       :||....:.....
Mouse  1077 PPPALYTCS----QCSGAGPSSQSGAALAHAISTSPLASQSSYNL-------LSPPDTSRDRTDY 1130

  Fly  1079 ASSVLDEITAV-------VPAVEPAKESPAVQAKPAPKKRFD------------------VITSF 1118
            .:|...|..|:       .|...|.....||..|..|..::|                  |....
Mouse  1131 VNSAFTEDEALSQHCQLEKPLRHPPLPEAAVTMKRPPPYQWDPMLGEDVWVPQERTAQPTVPNPL 1195

  Fly  1119 TDSPLF-----------------------TRKHRFGIGRSKETAGTENSTPLLGRKQDNGFSFVK 1160
            ..|||.                       |.....|.|......|:.|:..|.|.:..  .|...
Mouse  1196 KLSPLMLGQGQHLDVARVPFVPPKSPSSPTATFPTGYGMGMPYPGSYNNPSLPGVQAP--CSPKD 1258

  Fly  1161 QLSEVRWRRKE-----QPA----------QAQVNGSSNASTLERQP---QPEITGAACGTVEAT- 1206
            .||:.::.::|     |||          .....|||..|:::..|   .|..:.:.|..::.|
Mouse  1259 ALSQAQFAQQESAVVLQPAYPPSLSYCTLPPTYPGSSTCSSVQLPPIALHPWNSYSTCPPMQNTQ 1323

  Fly  1207 -----------------PVEAKASVSLHTQALT-TLENIISRLRDLDEGRLTPPSTPQRL----- 1248
                             |..|:....:.|:.:. |.:|....|      .||....|||.
Mouse  1324 GTLPPKPHLVVEKPLVSPPPAELQSHMGTEVMVETADNFQEVL------SLTESPVPQRTEKFGK 1382

  Fly  1249 -------PRSSPASPAA---SKKNKRQQSNSPIRHILNSPLLNRRQRKKQSIIESSDDE-----G 1298
                   .|:...|..|   .|..|..::.|....:::||.|.|.::|    ::|..|:     .
Mouse  1383 KNRKRLDSRAEEGSVQAITEGKVKKDARTLSDFNSLISSPRLGREKKK----VKSQKDQLKSKKL 1443

  Fly  1299 NQTNG-------------SGEESNNAGNG-----KQYRDLETFQ-----KAQLRQKLKRGKIEPN 1340
            |:||.             ||:|..|...|     |..|.|.|..     |.:...:.:.|::...
Mouse  1444 NKTNEFQDSSESEPELFISGDELMNQSQGSKKGWKSKRSLRTASELEEFKCRKASEKEDGRLGSQ 1508

  Fly  1341 GSASCANPAPVRREFVMHNKAPMWNEMSQVYQLDFGGRVTQESAKNFQIEFRGKQVMQFGRIDGN 1405
            |..           :||.||.|:|||.:||||||||||||||||||||||..|:|||||||||||
Mouse  1509 GFV-----------YVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQVMQFGRIDGN 1562

  Fly  1406 AYTLDFQYPFSALQAFAVALANVTQRLK 1433
            ||.|||||||||:|||||||||||||||
Mouse  1563 AYILDFQYPFSAVQAFAVALANVTQRLK 1590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tusp	NP_001263014.1	WD40	51..>295	CDD:225201	141/260 (54%)
		WD40	81..359	CDD:295369	140/294 (48%)
		WD40 repeat	91..126	CDD:293791	26/34 (76%)
		WD40 repeat	132..168	CDD:293791	25/35 (71%)
		WD40 repeat	173..208	CDD:293791	26/34 (76%)
		WD40 repeat	216..263	CDD:293791	15/63 (24%)
		WD40 repeat	270..333	CDD:293791	17/62 (27%)
		Tub	<588..>644	CDD:279506	37/101 (37%)
		Tub	<1355..1426	CDD:279506	59/70 (84%)
Tulp4	XP_006523311.1	WD40	<67..217	CDD:225201	101/149 (68%)
		WD40 repeat	85..123	CDD:293791	28/37 (76%)
		WD40 repeat	129..166	CDD:293791	25/36 (69%)
		WD40 repeat	171..205	CDD:293791	25/33 (76%)
		SOCS	373..408	CDD:383010	14/34 (41%)
		Atrophin-1	968..>1377	CDD:367360	89/464 (19%)
		Tub	<1513..1583	CDD:366500	59/69 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850639
Domainoid	1	1.000	133	1.000	Domainoid score	I5078
eggNOG	1	0.900	-	-		E1_KOG2041
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	687	1.000	Inparanoid score	I699
Isobase	1	0.950	-	0	Normalized mean entropy	S6908
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0006168
OrthoInspector	1	1.000	-	-		oto92758
orthoMCL	1	0.900	-	-		OOG6_108297
Panther	1	1.100	-	-	LDO	PTHR16517
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4245
SonicParanoid	1	1.000	-	-		X4453
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740