DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tusp and WDR35

DIOPT Version :9

Sequence 1:	NP_001263014.1	Gene:	Tusp / 43317	FlyBaseID:	FBgn0039530	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_001006658.1	Gene:	WDR35 / 57539	HGNCID:	29250	Length:	1181	Species:	Homo sapiens

Alignment Length:	383	Identity:	111/383 - (28%)
Similarity:	175/383 - (45%)	Gaps:	73/383 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHLHFERNI----NTKCDCTILSLSWMGKVPDDIPEDEGWKLNRTNYYQEGWLATGNVRGIVGV- 60
            |..:..:.|    |.|..|    :||                |:    ::|::|.|...|::.|
Human     1 MFFYLSKKISIPNNVKLQC----VSW----------------NK----EQGFIACGGEDGLLKVL 41

  Fly    61 ---TFTTSHCRKNMDYP--LRTNYNLRGHRSDVILVKWNEPYQKLASCDSSGIIFVWIKYEGRWS 120
               |.|.....:.:..|  |..|..|.||...|.:|.|||.||||.:.|.:|:|.||:.|:|.|.
Human    42 KLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWI 106

  Fly   121 IELINDRNTPVTH-FSWSHDGRMALICYQDGFVLVGSVAGQRYWSSMLNLESTITCGI------W 178
            .|:||:||..|.. .||:.||:...|.|:||.|:||||.|.|.|...|.       ||      |
Human   107 EEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLK-------GIQLSHVTW 164

  Fly   179 TPDDQQVYFGTTQGQVIVMDVHGAMVSQVQLSNDVPITSMAWSCEKFKMEEGEE--AEPGVTNAA 241
            :.|.:.:.||...|::.:.|..|..:.:::||..|.:|. |.|........|.|  .||...
Human   165 SADSKVLLFGMANGEIHIYDNQGNFMIKMKLSCLVNVTG-AISIAGIHWYHGTEGYVEPDCP--- 225

  Fly   242 KRSFVLAVSFQNGYIYLLKSFDDVSPAHINTCLNGALGMVMEWSNSRELLAVAGTLRTGVDGTKT 306
                .|||.|.||...:::..:|.:|..|:|   |...:.::|::...:|||||..:..:   :.
Human   226 ----CLAVCFDNGRCQIMRHENDQNPVLIDT---GMYVVGIQWNHMGSVLAVAGFQKAAM---QD 280

  Fly   307 EDMGTPSCYTNLVKFYTETGTCLYQAHIPCSSATVSAITWGHNDKRLFIATGTQVHIA 364
            :|:       |:|:|||..|..|....:|  ...:||::|.....::.:|..:.::.|
Human   281 KDV-------NIVQFYTPFGEHLGTLKVP--GKEISALSWEGGGLKIALAVDSFIYFA 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tusp	NP_001263014.1	WD40	51..>295	CDD:225201	85/258 (33%)
		WD40	81..359	CDD:295369	92/286 (32%)
		WD40 repeat	91..126	CDD:293791	18/34 (53%)
		WD40 repeat	132..168	CDD:293791	16/36 (44%)
		WD40 repeat	173..208	CDD:293791	9/40 (23%)
		WD40 repeat	216..263	CDD:293791	13/48 (27%)
		WD40 repeat	270..333	CDD:293791	17/62 (27%)
		Tub	<588..>644	CDD:279506
		Tub	<1355..1426	CDD:279506
WDR35	NP_001006658.1	WD 1	4..43		12/62 (19%)
		WD40	<5..192	CDD:225201	69/217 (32%)
		WD40 repeat	17..69	CDD:293791	15/75 (20%)
		WD40	<19..184	CDD:295369	64/195 (33%)
		WD 2	61..100		19/38 (50%)
		WD40 repeat	75..113	CDD:293791	19/37 (51%)
		WD 3	105..143		17/37 (46%)
		WD40 repeat	118..190	CDD:293791	26/78 (33%)
		WD 4	147..185		10/44 (23%)
		WD 5	193..241		16/55 (29%)
		WD40 repeat	206..251	CDD:293791	13/51 (25%)
		WD 6	246..288		13/54 (24%)
		WD40 repeat	256..300	CDD:293791	14/53 (26%)
		WD40 repeat	306..345	CDD:293791	5/24 (21%)
		Clathrin	<829..920	CDD:279031
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D91334at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820