Protein Alignment Tusp and tulp4b

DIOPT Version :10

• Sequence 1: NP_001263014.1
• Gene: Tusp / 43317
• FlyBaseID: FBgn0039530
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_068070623.1
• Gene: tulp4b / 562633
• ZFINID: ZDB-GENE-130530-708
• Length: 1902
• Species: Danio rerio
• Alignment Length: 1958
• Identity: 546/1958 - (27%)
• Similarity: 779/1958 - (39%)
• Gaps: 620/1958 - (31%)

  Fly    14 DCTILSLSWMGKVPDDIPEDEGWKLNRTNYYQEGWLATGNVRGIVGVTFTTSHCRKNMDYPLRTN 78
            |..||.|||.|:||....|.   .:.|..||:||||||||.||:||||||:||||::.:.|.|.|
Zfish    27 DSNILCLSWKGRVPKSEKEK---PVCRRRYYEEGWLATGNARGVVGVTFTSSHCRRDRNTPQRIN 88

  Fly    79 YNLRGHRSDVILVKWNEPYQKLASCDSSGIIFVWIKYEGRWSIELINDRNTPVTHFSWSHDGRMA 143
            :|||||.|:|:||:||||:||||:||..|.|||||:||||||:||:|||...|:.|:|||||..|
Zfish    89 FNLRGHNSEVVLVRWNEPFQKLATCDMEGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQA 153

  Fly   144 LICYQDGFVLVGSVAGQRYWSSMLNLESTITCGIWTPDDQQVYFGTTQGQVIVMDVHGAMVSQVQ 208
            ||.|:|||||||||:|||:|||.:||||.|||||||||||||.|||..|||||||.||.|::.|.
Zfish   154 LIAYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVL 218

  Fly   209 LSNDVPITSMAWSCEKFKMEEGEEAE-------PGVTNAAKRSFVLAVSFQNGYIYLLKSFDDVS 266
            |.....|.||:|:|..|.:|:..|::       |......|.  :|.|||.:|.|.|:.::||:|
Zfish   219 LHESDGIVSMSWNCPNFLVEDSTESDTDSDDQTPAHVQNLKP--LLTVSFISGDISLMNNYDDLS 281

  Fly   267 PAHINTCLNGALGMVMEWSNSRELLAVAGTLRTGVDGTKTEDMGTPSCYTN-LVKFYTETGTCLY 330
            |   |...:|...:.::|.:..:||||||..|.|        :.|.|...| |||||...|..:|
Zfish   282 P---NIIRSGLKDVEVQWCSQGDLLAVAGMERHG--------LPTDSLMRNALVKFYNVQGEHIY 335

  Fly   331 QAHIPCSSATVSAITWGHNDKRLFIATGTQVHIAWVSRRVASLQLLCRLEIQASVGSESLLPLLP 395
            ....| :...::.|.|||.|.|||:|.|..:::..|..|||||||||:..|.:::..|..:..|.
Zfish   336 TLETP-AQRPITTICWGHRDSRLFLACGPALYVVRVEHRVASLQLLCQQGIASALKEERDVGKLN 399

  Fly   396 LPSRIKSLIGNLFAQTIRCCVPDLKSLRDFVSRPPLCSTRLHCTMIRHDDDSNLSSGTCYTLYLE 460
            :||.:.|.:...|..||:..:||..::|||||.|...:.||||||.|.:::.. :.|.|||||||
Zfish   400 MPSLLCSYVTTAFIPTIKPPIPDPNNIRDFVSYPTAGNERLHCTMKRSEENPE-AGGPCYTLYLE 463

  Fly   461 YLGGLVPLLKGKRTSKIRPEFVIFDPQVNDSPLYFQYSAEAKSSSGSSQSTTTGNSGRTDSSDSD 525
            :||||||:|||:|.||:||||||.||:::.       .|:....:|.. |..|.:...:||||.:
Zfish   464 HLGGLVPILKGRRISKLRPEFVIMDPKMDG-------KADEVCVNGMI-SYMTDSCNCSDSSDIE 520

  Fly   526 FEER---------SRFG-SPRTPR-KKRVRPKRRHQAGDRLSASGGGVSNDP----------DSL 569
            ..:.         ||.. ||:.|| .|.:|.....:...:|:.:...:|..|          .||
Zfish   521 LSDEWVGRKSPKLSRGNRSPKLPRYSKHIRINMESRKSPKLAQTSQEMSRSPRLPKKPPLRSPSL 585

  Fly   570 DELAY-VDTLPEQEVKLVEVTSNIWGTKFKIHGLAKTVPANLGQVTYKTSLLHLQPRQMTLVITE 633
            ....: ||...|... |.:||||||||||||.|||..:|||||.|.||||||||||||||:.:.|
Zfish   586 TRREFPVDGFSEHNY-LAQVTSNIWGTKFKIVGLASFLPANLGAVIYKTSLLHLQPRQMTIYLPE 649

  Fly   634 LRD---DFPPGPDPSFNPNIFSEDEDEHHQHQGIHHDAVPQVNVITAQDGASLKPPI----IPQR 691
            :|.   ||.  ..|.||||:||||||:           :|    :....|.|...|.    ||
Zfish   650 VRKISLDFM--SLPVFNPNVFSEDEDD-----------LP----VMGPSGVSADNPSCTVNIP-- 695

  Fly   692 RLTDGASAPLIAP---MSPRPN-----RILARHKNSLTVNGERGSGSSAGLSPLARAESYDDDSS 748
                  .||:.:|   |||..:     .:||.....|.|.....:.::|..:..|.|.:....::
Zfish   696 ------IAPIHSPAQAMSPTQSIGLVQSLLANQNIQLDVLTNPTATAAAATAAAAAAAAAATAAA 754

  Fly   749 NESQEAGAA---GSQSTTVLLHQAPSNGSGPGPSCSKSI-------------------------T 785
            ..:..|.|.   .||.|....:..|:..|.||......:                         .
Zfish   755 ATAAAANATVSEHSQDTVTAQYTVPTRYSNPGQVIFSGLEMNNILSGTLPPPPHHLPQPPHQQRQ 819

  Fly   786 RPKTISSFKNSYSRSSSNSSCQSRHAISPLYCDGA-------VPTLQSPKNAVAP---------- 833
            :|:.....|:...........:.:|....|:....       ...||:|::....
Zfish   820 QPQDHQQSKHQQQLQPQQHHLKLQHQPQQLHQQSLQQQHMQHQQQLQTPQHQQLQQQHQQQLQQQ 884

  Fly   834 -------------------------------------------------------------SDII 837
                                                                         ..:.
Zfish   885 HQLQQQHQQQLQQQHQQQLQQQHQQQQLQQQHQQQQLQQQHQQQLQLQQQHQQLQQQHQQHQQLQ 949

  Fly   838 FERPAVPAAGQTTLMSYSSNA----------------------DYANNVVQVKNALM-------- 872
            .:...:....|..|..:....                      ......:|:::..|
Zfish   950 QQHQQLQQQHQQQLQQHQQQLHQQQMQQHQLQHQQQQIHQQQFQQQQQQLQIQHEQMQQQQQQMQ 1014

  Fly   873 ----------------SEPVRSANSHVNPVPLNLNLNLERMDARVK---CTAPTTSSTA------ 912
                            .:.::..:..:......:....::|..::|   ...|:.|..|
Zfish  1015 QQQQQIRQQILEMRQQQQQLQQQHQQIQMQHQQMQRQHQQMQQQLKMQMSLQPSPSGYATLSLHH 1079

  Fly   913 -------------------------KRREMLYIDEET--------QSPTPTPSSSSMKRTPTVVS 944
                                     ..|...:|:.:|        ..|.|.|.        ||||
Zfish  1080 LQLMPQIPHPDQPPDRGEQVLPLKVPSRPQSFIEMDTLEIQLRKVNPPPPYPG--------TVVS 1136

  Fly   945 IAPALPDS------ITRSCSVGYLDSVAITPSDEALSALRKDAPN----KRLILVDKKRN----- 994
            .|.|:|.:      ::............:|..:.:|..:....|.    :|:...|...|
Zfish  1137 AAAAIPTTAPPGLLVSNENGTTLSTDTCLTKDEFSLHPISLQYPTPLGYERITTFDSSGNVEEVC 1201

  Fly   995 RRKRQQQEDARRHKLQQTGKSKSLDSCDLLSLQTKLSSKEHEQV--------------------- 1038
            |.:|:...:...:.:|..|.|.:|          |::|.|:::|
Zfish  1202 RPRRRLLRNQNAYGMQGMGSSATL----------KVTSSENKKVQLPYSSATLSRLSVPRYSIPS 1256

  Fly  1039 ---------------VRKLQEISDSSACSS------------------AANTLCFKCRNNMS--- 1067
                           :|...:..|||...:                  |..||..|.:.|.|
Zfish  1257 GDPPPYPDTSNQMNTIRSPTQRIDSSLIHATLRRDRREPSLKVSQMVDAVRTLPTKSKMNGSLTL 1321

  Fly  1068 ------PSS--ACKRCQPSASSVLDEIT------------AVV----PAVEPAKESPAV----QA 1104
                  ||:  .|.:|..::||....:|            .||    |..:.|:.|..:    .|
Zfish  1322 SYQPRIPSALYTCTQCSSNSSSTSVSVTGGGTNSSGIAGGTVVRQDFPPGKGAQHSTIIVHSKSA 1386

  Fly  1105 KP-APKKRFDVI--------------TSFTDSPLFTRKHRFGIGRSKETAGTENSTPLLGRKQDN 1154
            .| |.:..::::              ::||:....:::..........|.|..|.|.    |:..
Zfish  1387 SPLASQSSYNLLSPTDNSRDRTVYVNSAFTEDETVSQQCHLEKSMRHLTLGDVNLTV----KRPP 1447

  Fly  1155 GFSFVKQLSEVRWRRKE------------------QPAQAQV-----------NGSSNAST---- 1186
            .:.:....:|..|..:|                  ||...::           ..|.|:.|
Zfish  1448 PYQWDSPAAEQLWIPQEQNLLPGPPPHKPPPFILSQPQHLEIARLPFVLSAKHTPSPNSMTLPSP 1512

  Fly  1187 --LERQPQPEITG-------------AACG---TVEATPVEAKAS-------------------- 1213
              |...|.|.:.|             ..||   .|.::|.....|
Zfish  1513 YQLSLSPYPSVVGHGGPPLQPLQSPAQTCGPNDMVASSPFSQPDSTLVLPPGYPSNVSNLGCCTL 1577

  Fly  1214 ------------VSLHTQAL----------------TTLENIISRLRDLDEGRLTPPSTPQRLPR 1250
                        :.||..:|                .||.:  ...:.|::..|:||..|...|.
Zfish  1578 PPMYPGTSSCNNLQLHPMSLHPWSTYSTCPPMPDHSATLPS--KTHQTLEKPVLSPPPPPPPPPP 1640

  Fly  1251 SSPASP----------------------------------------------------------- 1256
            ..|..|
Zfish  1641 PPPPPPLPPPPPPVEHLNLQSTSEVVAESGESFQDQSSLNESPQGAERFSKKGRKRLDSRAEEAN 1705

  Fly  1257 ----AASKKNKRQQSNSPIRHILNSPLLNRRQRKK-----------QSIIESSDDEGNQTNG--- 1303
                :..|..|..::.|....:::||.|..|::||           :.:..:|::..:.:..
Zfish  1706 MSGVSEGKSKKESRTLSDFNSLISSPRLGSREKKKPKGQKEPLNKTKKLSRTSNEFQDSSESEPE 1770

  Fly  1304 ---SGEESNNAGNG-----KQYRDLETFQKAQLRQKLKRGKIEPNGSASCANPAPVRREFVMHNK 1360
               ||:|..|....     |..|:|.|   |...:::|..|.......|..:...|   :||.||
Zfish  1771 LFISGDELMNQSQSSKKGWKSKRNLRT---ANELEEIKCRKANEREDRSLGSQGFV---YVMANK 1829

  Fly  1361 APMWNEMSQVYQLDFGGRVTQESAKNFQIEFRGKQVMQFGRIDGNAYTLDFQYPFSALQAFAVAL 1425
            .|:|||.:||||||||||||||||||||||..|:|||||||||||||.|||||||||:|||||||
Zfish  1830 QPLWNEATQVYQLDFGGRVTQESAKNFQIELDGRQVMQFGRIDGNAYILDFQYPFSAVQAFAVAL 1894

  Fly  1426 ANVTQRLK 1433
            ||||||||
Zfish  1895 ANVTQRLK 1902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tusp	NP_001263014.1	WD40	<81..221	CDD:441893	96/139 (69%)
		WD40 repeat	91..126	CDD:293791	25/34 (74%)
		WD40 repeat	132..168	CDD:293791	25/35 (71%)
		WD40 repeat	173..208	CDD:293791	26/34 (76%)
		WD40 repeat	216..263	CDD:293791	16/53 (30%)
		WD40 repeat	270..333	CDD:293791	21/63 (33%)
		Tub	<1249..1426	CDD:460094	85/261 (33%)
tulp4b	XP_068070623.1	WD40	<58..230	CDD:441893	118/171 (69%)
		WD40 repeat	98..136	CDD:293791	27/37 (73%)
		WD40 repeat	142..179	CDD:293791	25/36 (69%)
		WD40 repeat	184..218	CDD:293791	25/33 (76%)
		WD40 repeat	226..265	CDD:293791	10/40 (25%)
		WD40 repeat	285..338	CDD:293791	20/60 (33%)
		Tub	<1825..1895	CDD:460094	59/69 (86%)