Protein Alignment Tusp and Tulp4

DIOPT Version :10

• Sequence 1: NP_001263014.1
• Gene: Tusp / 43317
• FlyBaseID: FBgn0039530
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_001102607.1
• Gene: Tulp4 / 499016
• RGDID: 1564487
• Length: 1546
• Species: Rattus norvegicus
• Alignment Length: 1671
• Identity: 540/1671 - (32%)
• Similarity: 745/1671 - (44%)
• Gaps: 389/1671 - (23%)

  Fly    14 DCTILSLSWMGKVPDDIPEDEGWKLNRTNYYQEGWLATGNVRGIVGVTFTTSHCRKNMDYPLRTN 78
            |..||.|||.|:||....|.   .:.|..||:||||||||.||:||||||:||||::...|.|.|
  Rat    14 DSNILCLSWKGRVPKSEKEK---PVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRIN 75

  Fly    79 YNLRGHRSDVILVKWNEPYQKLASCDSSGIIFVWIKYEGRWSIELINDRNTPVTHFSWSHDGRMA 143
            :|||||.|:|:||:|||||||||:||:.|.|||||:||||||:||:|||...|:.|:|||||..|
  Rat    76 FNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQA 140

  Fly   144 LICYQDGFVLVGSVAGQRYWSSMLNLESTITCGIWTPDDQQVYFGTTQGQVIVMDVHGAMVSQVQ 208
            ||.|:|||||||||:|||:|||.:||||.|||||||||||||.|||..|||||||.||.|::.|.
  Rat   141 LISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVL 205

  Fly   209 LSNDVPITSMAWSCEKFKMEEGEEAEPG-----------------VTNAAKRSFVLAVSFQNGYI 256
            |.....|.||:|:...|.:|:..|::..                 |.|...   :|.|||.:|.|
  Rat   206 LHESDGILSMSWNYPIFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNIKP---LLTVSFTSGDI 267

  Fly   257 YLLKSFDDVSPAHINTCLNGALGMVMEWSNSRELLAVAGTLRTGVDGTKTEDMGTPSCYTNLVKF 321
            .|:.::||:||..|.   :|...:|.:|....:||||||..:   ....:|....|...:.:|||
  Rat   268 SLMNNYDDLSPTVIR---SGLKEVVAQWCTQGDLLAVAGMEQ---QAQLSELPNGPLLKSAMVKF 326

  Fly   322 YTETGTCLYQAHIPCSSATVSAITWGHNDKRLFIATGTQVHIAWVSRRVASLQLLCRLEIQASVG 386
            |...|..::..........:| |.|||.|.||.:|:|..:::..|..||:||||||:..|.:::.
  Rat   327 YNVRGEHIFTLDTLVQRPIIS-ICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASTLR 390

  Fly   387 SESLLPLLPLPSRIKSLIGNLFAQTIRCCVPDLKSLRDFVSRPPLCSTRLHCTMIRHDDDSNLSS 451
            .:..:..|.||.|:.|.:...|..||:..:||..::|||||.|...:.||||||.|.:||..: .
  Rat   391 EDKDVNKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDDPEV-G 454

  Fly   452 GTCYTLYLEYLGGLVPLLKGKRTSKIRPEFVIFDPQVNDSPLYFQYSAEAKSSS--GSSQ-STTT 513
            |.||||||||||||||:|||:|.||:||||||.||:           .::||..  |::. ||..
  Rat   455 GPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPR-----------TDSKSDEIYGNNLISTVI 508

  Fly   514 GNSGRTDSSDSDFEER---------SRFG-SPRTPR---KKRVRPKRRHQAGD-----RLSASGG 560
            .:...:||||.:..:.         ||.. ||:.||   :.|..||....|.:     ||.....
  Rat   509 DSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRISIEARKSPKLPRAAQEISRSPRLPMRKP 573

  Fly   561 GVSNDPDSLDELAYVDTLPEQEVKLVEVTSNIWGTKFKIHGLAKTVPANLGQVTYKTSLLHLQPR 625
            .:.:...:..|..:.|.  .|...|.:||||||||||||.|||..:|.|||.|.|||||||||||
  Rat   574 SMGSPSLTRREFPFEDI--TQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPR 636

  Fly   626 QMTLVITELRD---DFPPGPDPSFNPNIFSEDEDEHHQHQGIHHDAVPQVNVITAQDGASLKPPI 687
            |||:.:.|:|.   |:.  ..|.||||:||||||:           :|    :|...|
  Rat   637 QMTIYLPEVRKISMDYI--NLPVFNPNVFSEDEDD-----------LP----VTGASG------- 677

  Fly   688 IPQRRLTDGASAPLIAPMSPRPNRILARHKNSLTVNGERGSGSSAGLSPLARAESYDDDSSNESQ 752
            :|:.......:.| |||:          |.::..::..:..|....|  ||......|..:|::.
  Rat   678 VPENNPPCTVNIP-IAPI----------HSSAQALSPTQSIGLVQSL--LANQNVQLDVLTNQTT 729

  Fly   753 EAGAAGSQSTTVLLHQAPSNGSGPGP------SCSKSITRPKTIS---------------SFKNS 796
            ..|:..........:...|..|.||.      ...:.|..|..:.               |..:.
  Rat   730 AVGSVEHAGDAATQYPVSSRYSNPGQVIFGGVEMGRIIQNPPQLPLPPPPPPPPQGPIQLSAVDH 794

  Fly   797 YSRSSSNSSCQSRHAISPL--YCDG---------------------------AVPTLQSPKNAVA 832
            .:|...:.. :|..|:.|:  ..:|                           |.||..:|...:.
  Rat   795 GARDHEHLQ-KSAKALRPVPQLAEGDAVVFSAPQEVQVAKMNPPPPYPGTIPAAPTTAAPPPPLP 858

  Fly   833 PS----DIIFER------PAV----PAAGQTTLMSYSSNADYANNVVQVKNALMSEPVRSANSHV 883
            |.    |:..::      |..    |..|...:.::.|:.: ...|.:.:..::.    |.|::.
  Rat   859 PPQPPVDVCLKKGDFSLYPTAAHYQPPLGYERITTFDSSGN-VEEVCRPRTRMLC----SQNTYT 918

  Fly   884 NPVP-LNLNLNLERMDARVKCTAPTTSSTAKRREMLYIDEETQSPTPTPSSSSMKRTPTVVSIAP 947
            .|.| .:..|.|...:.:|  ..|.||:|..|..:......|..|.|.|..:|.
  Rat   919 LPGPGSSATLRLTATEKKV--PQPCTSATLNRLTVPRYSIPTGDPPPYPEIASQ----------- 970

  Fly   948 ALPDSITRSCSVGYLDSVAITPSDEALSALRKDAPNKRLILVDKKRNRR----KRQQQEDARRHK 1008
                               :.....|...|     :..||....:||.|    |..|..|:.|..
  Rat   971 -------------------LAQGRNATQRL-----DNSLIHATLRRNNREVALKMAQLADSSRAP 1011

  Fly  1009 LQQTGKSK----------------SLDSCDLLSLQTKLSSKEHEQVVRKLQEISDSSACSSAANT 1057
            ||...|.|                :|.:|.    |...:....:........||.|...|.::..
  Rat  1012 LQPPAKPKGGTGGAVAQLPARPPPALYTCS----QCSGAGPSSQSGAALAHAISTSPLASQSSYN 1072

  Fly  1058 LCFKCRNNMSP---------------------SSACKRCQPSASSVLDEITAVVPAVEP------ 1095
            |       :||                     |..|:..:|.....|.|.|..:....|
  Rat  1073 L-------LSPPDTSRDRTDYVNSAFTEDEALSQHCQLEKPLRHPPLPEATVTMKRPPPYQWDPV 1130

  Fly  1096 -------AKESPAVQAKPAPKK----------RFDVI------TSFTDSPLFTRKHRFGIGRSKE 1137
                   .:|..|....|.|.|          ..||.      .....||..|.:..:|:|  ..
  Rat  1131 LGEDVWVPQERTAQPTVPNPLKLSPLMIGQGQHLDVARVPFVSPKSPSSPTATFQTGYGMG--VP 1193

  Fly  1138 TAGTENSTPLLG-------RKQDNGFSFVKQLSEVRWRRKEQPAQAQVN------GSSNASTLER 1189
            ..|:.|:..|.|       :...:...|.:|.|.|..:....|:.:...      |||..|:|:.
  Rat  1194 YPGSYNTPSLPGVQAPCSPKDALSPAQFAQQESAVVLQPAYPPSLSYCTLPPTYPGSSTCSSLQL 1258

  Fly  1190 QP---QPEITGAAC-------GTVEATP--VEAKASVS---------LHTQALT-TLENIISRLR 1232
            .|   .|..:.:.|       ||:.:.|  |..|..||         :.|:.:. |.:|....|
  Rat  1259 PPIALHPWNSYSTCPPMQNTQGTLPSKPHLVVEKPLVSPPPAELQSHMGTEVMVETADNFQEVL- 1322

  Fly  1233 DLDEGRLTPPSTPQRL------------PRSSPASPAA---SKKNKRQQSNSPIRHILNSPLLNR 1282
                 .||....|||.            .|:...|..|   .|..|..::.|....::.||.|.|
  Rat  1323 -----SLTESPVPQRTEKFGKKNRKRLDSRAEEGSVQAITEGKVRKDARTLSDFNSLIASPRLGR 1382

  Fly  1283 RQRKKQS-------------------------IIESSDDEGNQTNGSGEESNNAGNGKQYRDLET 1322
            .::|.:|                         :..|.|:..||:.||.:...:..:.:...:||.
  Rat  1383 EKKKVKSQKDQLKSKKLNKTNEFQDSSESEPELFISGDELMNQSQGSKKGWKSKRSLRTASELEE 1447

  Fly  1323 FQKAQLRQKLKRGKIEPNGSASCANPAPVRREFVMHNKAPMWNEMSQVYQLDFGGRVTQESAKNF 1387
            |:..:..:| :.|::...|..           :||.||.|:|||.:|||||||||||||||||||
  Rat  1448 FKGRKASEK-EDGRLGSQGFV-----------YVMANKQPLWNEATQVYQLDFGGRVTQESAKNF 1500

  Fly  1388 QIEFRGKQVMQFGRIDGNAYTLDFQYPFSALQAFAVALANVTQRLK 1433
            |||..|:|||||||||||||.|||||||||:|||||||||||||||
  Rat  1501 QIELEGRQVMQFGRIDGNAYILDFQYPFSAVQAFAVALANVTQRLK 1546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tusp	NP_001263014.1	WD40	<81..221	CDD:441893	97/139 (70%)
		WD40 repeat	91..126	CDD:293791	26/34 (76%)
		WD40 repeat	132..168	CDD:293791	25/35 (71%)
		WD40 repeat	173..208	CDD:293791	26/34 (76%)
		WD40 repeat	216..263	CDD:293791	15/63 (24%)
		WD40 repeat	270..333	CDD:293791	17/62 (27%)
		Tub	<1249..1426	CDD:460094	83/204 (41%)
Tulp4	NP_001102607.1	WD40	<45..217	CDD:441893	119/171 (70%)
		WD40 repeat	85..123	CDD:293791	28/37 (76%)
		WD40 repeat	129..166	CDD:293791	25/36 (69%)
		WD40 repeat	171..205	CDD:293791	25/33 (76%)
		SOCS	373..408	CDD:470605	14/34 (41%)
		PHA03247	<1010..1299	CDD:223021	57/301 (19%)
		Tub	<1469..1539	CDD:460094	59/69 (86%)