DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tusp and wdr35

DIOPT Version :9

Sequence 1:	NP_001263014.1	Gene:	Tusp / 43317	FlyBaseID:	FBgn0039530	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	XP_002934527.2	Gene:	wdr35 / 100496375	XenbaseID:	XB-GENE-985175	Length:	1181	Species:	Xenopus tropicalis

Alignment Length:	371	Identity:	106/371 - (28%)
Similarity:	172/371 - (46%)	Gaps:	69/371 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NINTKCDCTILSLSWMGKVPDDIPEDEGWKLNRTNYYQEGWLATGNVRGIVGVTFTTSHCR---- 68
            ||..||      :||                |:    .:|::|.|...|::.|........
Frog    14 NICLKC------ISW----------------NK----DQGYIACGGESGLLKVLKLEMQAEDAKL 52

  Fly    69 KNMDYP--LRTNYNLRGHRSDVILVKWNEPYQKLASCDSSGIIFVWIKYEGRWSIELINDRNTPV 131
            |.:..|  |..|..|.||...|.:|.|||.:|||.:.|.:|:|.||:.|:|.|..|:||:||..|
Frog    53 KGLAAPSNLSMNQTLEGHSGSVQVVTWNEHFQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSV 117

  Fly   132 TH-FSWSHDGRMALICYQDGFVLVGSVAGQRYWSSMLNLESTITCGI-WTPDDQQVYFGTTQGQV 194
            .. .||:.||:...|.|:||.|:||||.|.|.|..  .|:....|.: |:||.:.:.||...|::
Frog   118 VRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGK--ELKGIQLCHVAWSPDSKILLFGMANGEI 180

  Fly   195 IVMDVHGAMVSQ------VQLSNDVPITSMAWSCEKFKMEEGEEAEPGVTNAAKRSFVLAVSFQN 253
            .:.|..|..:.:      |.:|..:.|..|.|    :...:| ..||...       .||:.|.|
Frog   181 HLYDNQGNFIVKMVLSCLVNVSGALSIAGMHW----YSGNKG-YVEPDCP-------CLAICFDN 233

  Fly   254 GYIYLLKSFDDVSPAHINTCLNGALGMVMEWSNSRELLAVAGTLRTGVDGTKTEDMGTPSCYTNL 318
            |...:::..:|.:|..|:|.:|   .:.::|::...:||:||:.|.   .::.:|:       |:
Frog   234 GRCQIMRHENDENPVLIDTGMN---VVSIQWNHCGSVLAIAGSQRA---ASQDKDI-------NI 285

  Fly   319 VKFYTETGTCLYQAHIPCSSATVSAITWGHNDKRLFIATGTQVHIA 364
            |:|||..|..|....:|  ...:||::|.....|:.:|..:.::.|
Frog   286 VQFYTPFGEHLRTLKVP--GKQISAVSWEGGGLRIGLAVDSYIYFA 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tusp	NP_001263014.1	WD40	51..>295	CDD:225201	79/257 (31%)
		WD40	81..359	CDD:295369	89/285 (31%)
		WD40 repeat	91..126	CDD:293791	17/34 (50%)
		WD40 repeat	132..168	CDD:293791	16/36 (44%)
		WD40 repeat	173..208	CDD:293791	9/41 (22%)
		WD40 repeat	216..263	CDD:293791	10/46 (22%)
		WD40 repeat	270..333	CDD:293791	17/62 (27%)
		Tub	<588..>644	CDD:279506
		Tub	<1355..1426	CDD:279506
wdr35	XP_002934527.2	WD40 repeat	18..69	CDD:293791	15/76 (20%)
		WD40	<19..215	CDD:225201	69/227 (30%)
		WD40 repeat	74..111	CDD:293791	17/36 (47%)
		WD40 repeat	119..157	CDD:293791	17/39 (44%)
		WD40 repeat	159..196	CDD:293791	9/36 (25%)
		WD40 repeat	253..300	CDD:293791	15/59 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D91334at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010