DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tusp and tulp4

DIOPT Version :9

Sequence 1:	NP_001263014.1	Gene:	Tusp / 43317	FlyBaseID:	FBgn0039530	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_001107316.1	Gene:	tulp4 / 100135107	XenbaseID:	XB-GENE-975849	Length:	1568	Species:	Xenopus tropicalis

Alignment Length:	1679	Identity:	551/1679 - (32%)
Similarity:	763/1679 - (45%)	Gaps:	383/1679 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DCTILSLSWMGKVPDDIPEDEGWKLNRTNYYQEGWLATGNVRGIVGVTFTTSHCRKNMDYPLRTN 78
            |..||.|||.|:||....|.   .:.|..||:||||||||.||:||||||.||||::.:.|.|||
Frog    14 DSNILCLSWKGRVPKSEKEK---PVCRRRYYEEGWLATGNGRGVVGVTFTLSHCRRDRNTPQRTN 75

  Fly    79 YNLRGHRSDVILVKWNEPYQKLASCDSSGIIFVWIKYEGRWSIELINDRNTPVTHFSWSHDGRMA 143
            :|||||.|:|:||:||||:||||:||:.|.|||||:||||||:||:|||...|:.|:|||||..|
Frog    76 FNLRGHNSEVVLVRWNEPFQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQA 140

  Fly   144 LICYQDGFVLVGSVAGQRYWSSMLNLESTITCGIWTPDDQQVYFGTTQGQVIVMDVHGAMVSQVQ 208
            ||.|:|||||||||:|||:|||.:||||.|||||||||||||.|||..|||||||.||.|::.|.
Frog   141 LISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVL 205

  Fly   209 LSNDVPITSMAWSCEKFKMEEGEEAE-------PGVTNAAKRSF-------VLAVSFQNGYIYLL 259
            |.....|.:|:|:...|.:|:..|::       |.....|....       :|.|.|.:|.|.|:
Frog   206 LHESDGIVNMSWNYPSFLVEDSSESDTDSDDYSPPQDGPAAYPIPVENIKPLLTVGFTSGDIRLM 270

  Fly   260 KSFDDVSPAHINTCLNGALGMVMEWSNSRELLAVAGTLRTGVDGTKTEDMGTPSCYTNLVKFYTE 324
            .::||:||..:.   :|...:|::|....:||||||..:..:   ..|.:...|..:.|:|||..
Frog   271 NNYDDLSPTIVR---SGLKDVVVQWCTQGDLLAVAGMEKQNL---IPEHVNGNSLKSALIKFYNV 329

  Fly   325 TGTCLYQAHIPCSSATVSAITWGHNDKRLFIATGTQVHIAWVSRRVASLQLLCRLEIQASVGSES 389
            .|..:|....|. ...:::|.|||.|.|||:|:|..:::..|..|||||||||:..|..|:..:.
Frog   330 RGEHIYTLETPV-QRPITSICWGHRDSRLFLASGPALYVVRVEHRVASLQLLCQQTIATSLSDDK 393

  Fly   390 LLPLLPLPSRIKSLIGNLFAQTIRCCVPDLKSLRDFVSRPPLCSTRLHCTMIRHDDDSNLSSGTC 454
            .:..|.||.|:.|.:...|..||:..:||..::|||||.|...:.||||||.|.:||..: .|.|
Frog   394 DICKLNLPPRLCSYLTTAFIPTIKPPIPDPNNMRDFVSYPTSGNERLHCTMKRTEDDPEV-GGPC 457

  Fly   455 YTLYLEYLGGLVPLLKGKRTSKIRPEFVIFDPQVNDSPLYFQYSAEAKSSSGSSQ-STTTGNSGR 518
            |||||||||||||:|||:|.||:||||||.||:.:         |:.....|:.. |:...:...
Frog   458 YTLYLEYLGGLVPVLKGRRISKLRPEFVIMDPKTD---------AKTDEIYGNGLISSVIDSCNC 513

  Fly   519 TDSSDSDFEER---------SRFG-SPRTPR---KKRVRPKRRHQAGD-----RLSASGGGVSND 565
            :||||.:..:.         ||.. ||:.||   :.|..||....|.:     ||......:.:.
Frog   514 SDSSDIELSDDWAAKKSPKISRASKSPKLPRINIEARKSPKLPRAAQEITRSPRLPIRKPSIGSP 578

  Fly   566 PDSLDELAYVDTLPEQEVKLVEVTSNIWGTKFKIHGLAKTVPANLGQVTYKTSLLHLQPRQMTLV 630
            ..:..|....|.  .|...|.:||||||||||||.|||..:|||||.|.||||||||||||||:.
Frog   579 SLTRRECPLEDI--TQHNYLAQVTSNIWGTKFKIVGLAAFLPANLGAVIYKTSLLHLQPRQMTIY 641

  Fly   631 ITELRD---DFPPGPDPSFNPNIFSEDEDE-------------------------HHQHQ----- 662
            :.|:|.   |:.  ..|.||.|:||||||:                         |...|
Frog   642 LPEVRKISMDYI--NLPVFNTNVFSEDEDDLPVTGTSGAPENNPPCTVNIPIAPIHSSAQAMSPT 704

  Fly   663 ---GIHHDAVPQVNV---ITAQDGASLKPPI-----------IPQRRLTDG-------ASAPLIA 703
               |:....:...||   :.|....:..||:           .|.|....|       ....||.
Frog   705 QSIGLVQSLLANQNVQLDVLANQMVAAAPPLDHPTESAVPYPAPNRYANPGQVIFGGVEMGRLIQ 769

  Fly   704 PMSPRPNRILAR-----HKNSLTVNGERGSGSSAGLSPLARAESYDDDSS--------NESQEAG 755
            |  |:|...:|.     .:.|:..:.||.........||.....|.:..:        .::.:..
Frog   770 P--PQPPMQMAHPPQGSAQMSIIDHSERDHEHLQKTKPLRTIPQYAEGDAVVFTAVQEIQNHKLN 832

  Fly   756 AAGSQSTTVLLHQAPSNGSGPGPS--------CSKSITRPKTISSFKN-------SYSR-----S 800
            .......|:   .||...:.|.|.        |||.    ...|.|.|       .|.|     |
Frog   833 PPPPYPGTI---PAPPTSAAPPPPISQPPVDLCSKK----SEFSLFANPHYQPPLGYERITTFDS 890

  Fly   801 SSN--SSCQSRHAISPLYCDGAVPTLQSPKNA----VAPSDIIFERPAVPAA-GQTTLMSYSSNA 858
            |.|  ..|:.|   ..:.|.....|||.|.::    |:.::...::|...|. .:.|:..||..:
Frog   891 SGNVEEVCRPR---MRMLCTQNTYTLQGPGSSATLRVSATEKKIKQPCTSATLNRLTVPRYSIPS 952

  Fly   859 -------DYANNVVQVKNALMSEPVRSANSHVNPVPLNLNLNLERMDARVKCTAPTTSSTAKRRE 916
                   :.|..:.|.:|  |::.:.|:..|.       .|.....:|.:|
Frog   953 GDPPPYPEIAAQLAQGRN--MAQRIDSSLIHA-------TLRRNSREAALK-------------- 994

  Fly   917 MLYIDEETQSPTPTPSSSS--------MKRTPTVVSIAPALPDSITRSCSVGYLDSV----AITP 969
            |..|.:..::|...|..|.        .:||||      ||......|...|.:.|.    .|:.
Frog   995 MAQIVDNQRAPQQHPPKSKSNVVPAQFQQRTPT------ALYTCSQCSSGTGVMSSSNHTGNIST 1053

  Fly   970 SDEALSALRKD-----APNKRLILVDKKRNRRKRQQQEDARRHKLQQTGKSKSLDSCDLLSLQTK 1029
            |...:.::|.|     .|.:..::|                 |....|..: |..|.:|||  ..
Frog  1054 STIGVGSIRPDLSTGSGPQQSTVIV-----------------HSASTTPLA-SQSSYNLLS--PA 1098

  Fly  1030 LSSKEHEQVVRK--LQEISDSSACSSAANTLCFKCRNNMSPSSA---CKRCQPSA--SSVLDEIT 1087
            .||::....:..  .::.:.|..||..      |...::|.:.|   .||..|..  ..|.::|.
Frog  1099 ESSRDRTDYINSAFTEDEAVSQHCSVE------KPVRHLSLAEAGLTIKRPPPYQWDPRVSEDIW 1157

  Fly  1088 AVVPAVEPAKESPAVQAKPAP-----KKRFD------VITSFTDSPLFTRKHRFGIGRSKETAGT 1141
              ||....|..:..:..:|.|     .:..|      :......||:.|.:..:|:|.....|
Frog  1158 --VPQERTAHNTLPIPKRPPPLIIGQNQHLDMSRVPFISPKSPTSPISTFQANYGVGIPYTGA-- 1218

  Fly  1142 ENSTPLLGRKQDNGFSFVKQLSEVRWRRKE-----QPA----------QAQVNGSSNASTLERQP 1191
             .|.||..::..|..|..:.||..::.::|     |||          .....|:|..:.|:...
Frog  1219 -YSVPLPHQQIPNPCSPKEALSPPQFVQQEPTIVIQPAYPPNLPCCPLPPMYPGNSTCNGLQLPA 1282

  Fly  1192 ---QPEITGAACGTVEA------------------TPVEAKASVSLHTQALT-TLENIISRLRDL 1234
               .|..:..||..|::                  :|...:...::.|:.:. |.:|....|
Frog  1283 IALHPWNSYNACPPVQSVQAALPPKPHVVPEKTVLSPPHPELQSNIGTEVMVETADNFQEVL--- 1344

  Fly  1235 DEGRLTPPSTPQRLPRSSPASPAASKKNKRQQSNS---------------------PIRHILNSP 1278
               .||....|||..:      .|.|..||..|.:                     ....::.||
Frog  1345 ---SLTESPVPQRTDK------FAKKNRKRIDSRAEEGNVQAITEGKVKKDARTLGDFNSLIASP 1400

  Fly  1279 LLNRRQRKKQSIIESSDDE-----GNQTNG-------------SGEE------SNNAG-----NG 1314
            .|.|.::|    ::|..|:     .|:||.             ||:|      ||..|     |.
Frog  1401 RLGREKKK----VKSQKDQLKSKKLNKTNEFQDSSESEPELFISGDELMNQSQSNKKGWKTKRNL 1461

  Fly  1315 KQYRDLETFQKAQLRQKLKRGKIEPNGSASCANPAPVRREFVMHNKAPMWNEMSQVYQLDFGGRV 1379
            :...||:.|:..:..:| ..|::...|..           :||.||.|:|||.:|||||||||||
Frog  1462 RTASDLDEFKCRKANEK-DDGRLGSQGFV-----------YVMANKQPLWNEATQVYQLDFGGRV 1514

  Fly  1380 TQESAKNFQIEFRGKQVMQFGRIDGNAYTLDFQYPFSALQAFAVALANVTQRLK 1433
            |||||||||||..|:|||||||||||||.|||||||||:|||||||||||||||
Frog  1515 TQESAKNFQIELEGRQVMQFGRIDGNAYILDFQYPFSAVQAFAVALANVTQRLK 1568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tusp	NP_001263014.1	WD40	51..>295	CDD:225201	138/257 (54%)
		WD40	81..359	CDD:295369	138/291 (47%)
		WD40 repeat	91..126	CDD:293791	25/34 (74%)
		WD40 repeat	132..168	CDD:293791	25/35 (71%)
		WD40 repeat	173..208	CDD:293791	26/34 (76%)
		WD40 repeat	216..263	CDD:293791	13/60 (22%)
		WD40 repeat	270..333	CDD:293791	17/62 (27%)
		Tub	<588..>644	CDD:279506	38/58 (66%)
		Tub	<1355..1426	CDD:279506	59/70 (84%)
tulp4	NP_001107316.1	WD40	48..>410	CDD:225201	176/368 (48%)
		WD40	78..>213	CDD:295369	93/134 (69%)
		WD40 repeat	85..123	CDD:293791	27/37 (73%)
		WD40 repeat	129..166	CDD:293791	25/36 (69%)
		WD40 repeat	171..205	CDD:293791	25/33 (76%)
		WD40 repeat	213..282	CDD:293791	17/68 (25%)
		WD40 repeat	289..338	CDD:293791	16/51 (31%)
		SOCS_box	376..409	CDD:198037	13/32 (41%)
		Tub	<588..>646	CDD:279506	39/59 (66%)
		Tub	<1491..1561	CDD:279506	59/69 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5053
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	688	1.000	Inparanoid score	I686
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0006168
OrthoInspector	1	1.000	-	-		oto103037
Panther	1	1.100	-	-	LDO	PTHR16517
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070