DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tusp and Gm2808

DIOPT Version :9

Sequence 1:	NP_001263014.1	Gene:	Tusp / 43317	FlyBaseID:	FBgn0039530	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	XP_017173259.1	Gene:	Gm2808 / 100040500	MGIID:	3780977	Length:	1062	Species:	Mus musculus

Alignment Length:	1165	Identity:	300/1165 - (25%)
Similarity:	415/1165 - (35%)	Gaps:	363/1165 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 STTTGNSGRTDSSDSDFEE-----------RSRFGSPRTPR---KKRVRPKRRHQAGD-----RL 555
            ||...:...:||||.:..:           ||. .||:.||   :.|..||....|.:     ||
Mouse    20 STVIDSCNCSDSSDIELSDDWAAKKSPKISRSS-KSPKLPRISIEARKSPKLPRAAQEISRSPRL 83

  Fly   556 SASGGGVSNDPDSLDELAYVDTLPEQEVKLVEVTSNIWGTKFKIHGLAKTVPANLGQVTYKTSLL 620
            ......:.:...:..|:.:.|.  .|...|.:||||||||||||.|||..:|.|||.|.||||||
Mouse    84 PMRKPSMGSPSLTRREVPFEDI--TQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLL 146

  Fly   621 HLQPRQMTLVITELRD---DFPPGPDPSFNPNIFSEDEDEHHQHQGIHHDAVPQVNVITAQDGA- 681
            ||||.|||:.:.|:|.   |:.  ..|.||||:||||||:           :|    :|...|.
Mouse   147 HLQPWQMTIYLPEVRKISMDYI--NLPVFNPNVFSEDEDD-----------LP----VTGASGVP 194

  Fly   682 SLKPPI---IPQRRLTDGASAPLIAPMSPRPNRILARHKNSLTVNGERGSGSSAGL--SPLARAE 741
            ...||.   ||...:...|.|     :||.                     .|.||  |.||...
Mouse   195 ENNPPCTVNIPIAPIYSSAQA-----LSPT---------------------QSIGLVQSLLANQN 233

  Fly   742 SYDDDSSNESQEAGAAGSQSTTVLLHQAPSNGSGPG----------------------PSCSKSI 784
            ...|..:|::...|:|.........:...|..|.||                      |......
Mouse   234 VQLDVLTNQTTAVGSAEHAGDAATQYPVSSRYSNPGQVIFGGVEMGRIIQNPPQLPLPPPPPPPP 298

  Fly   785 TRPKTISSFKN-SYSRSSSNSSCQSRHAISPLYCDG---------------------------AV 821
            ..|..:|:..: .........|.::...:..|..:|                           |.
Mouse   299 QAPMQLSAVDHGDRDHEHLQKSAKALRPVPQLAAEGDAVVFSAPQEVQVAKMNPPPPYPGTIPAA 363

  Fly   822 PTLQSPKNAVAPS----DIIFER------PAV----PAAGQTTLMSYSSNADYANNVVQVKNALM 872
            ||..:|...:.|.    |:..::      |..    |..|...:.::.|:.: ...|.:.:..::
Mouse   364 PTTAAPPPPLPPPQPPVDVCLKKGDFSLYPTAAHYQPPLGYERITTFDSSGN-VEEVCRPRTRML 427

  Fly   873 SEPVRSANSHVNPVP-LNLNLNLERMDARVKCTAPTTSSTAKRREMLYIDEETQSPTPTPSSSSM 936
            .    |.|::..|.| .:..|.|...:.:|  ..|.||:|..|..:......|..|.|.|
Mouse   428 C----SQNTYTLPGPGSSATLRLTATEKKV--PQPCTSATLNRLTVPRYSIPTGDPPPYP----- 481

  Fly   937 KRTPTVVSIAPALPDSITRSCSVGYLDSVAITPSDEALSALRKDAPNKRLILVDKKRNRR----K 997
                   .||..|...  ||                  :|.|.|   ..||....:||.|    |
Mouse   482 -------EIASQLAQG--RS------------------AAQRLD---NSLIHATLRRNNREVALK 516

  Fly   998 RQQQEDARRHKLQQTGKSK----------------SLDSCDLLSLQTKLSSKEHEQVVRKLQEIS 1046
            .....|:.|..||...|.|                :|.:|.    |...:....:........||
Mouse   517 MPHLADSSRAPLQPLAKPKGGAAGAVAQLPARPPPALYTCS----QCSGAGPSSQSGAALAHAIS 577

  Fly  1047 DSSACSSAANTLCFKCRNNMSPSSACKRCQPSASSVLDEITAV-------VPAVEPAKESPAVQA 1104
            .|...|.::..|       :||....:......:|...|..|:       .|...|.....||..
Mouse   578 TSPLASQSSYNL-------LSPPDTSRDRTDYVNSAFTEDEALSQHCQLEKPLRHPPLPEAAVTM 635

  Fly  1105 KPAPKKRFD------------------VITSFTDSPLF-----------------------TRKH 1128
            |..|..::|                  |......|||.                       |...
Mouse   636 KRPPPYQWDPMLGEDVWVPQERTAQPTVPNPLKLSPLMLGQGQHLDVARVPFVSPKSPSSPTATF 700

  Fly  1129 RFGIGRSKETAGTENSTPLLGRKQDNGFSFVKQLSEVRWRRKE-----QPA----------QAQV 1178
            ..|.|......|:.|:..|.|.:..  .|....||:.::.::|     |||          ....
Mouse   701 PTGYGMGMPYPGSYNNPSLPGVQAP--CSPKDALSQAQFAQQESAVVLQPAYPPSLSYCTLPPTY 763

  Fly  1179 NGSSNASTLERQP---QPEITGAACGTVEAT------------------PVEAKASVSLHTQALT 1222
            .|||..|:::..|   .|..:.:.|..::.|                  |..|:....:.|:.:.
Mouse   764 PGSSTCSSVQLPPIALHPWNSYSTCPPMQNTQGTLPPKPHLVVEKPLVSPPPAELQSHMGTEVMV 828

  Fly  1223 -TLENIISRLRDLDEGRLTPPSTPQRL------------PRSSPASPAA---SKKNKRQQSNSPI 1271
             |.:|....|      .||....|||.            .|:...|..|   .|..|..::.|..
Mouse   829 ETADNFQEVL------SLTESPVPQRTEKFGKKNRKRLDSRAEEGSVQAITEGKVKKDARTLSDF 887

  Fly  1272 RHILNSPLLNRRQRKKQSIIESSDDE-----GNQTNG-------------SGEESNNAGNG---- 1314
            ..:::||.|.|.::|    ::|..|:     .|:||.             ||:|..|...|
Mouse   888 NSLISSPRLGREKKK----VKSQKDQLKSKKLNKTNEFQDSSESEPELFISGDELMNQSQGSKKG 948

  Fly  1315 -KQYRDLETFQ-----KAQLRQKLKRGKIEPNGSASCANPAPVRREFVMHNKAPMWNEMSQVYQL 1373
             |..|.|.|..     |.:...:.:.|::...|..           :||.||.|:|||.:|||||
Mouse   949 WKSKRSLRTASELEEFKCRKASEKEDGRLGSQGFV-----------YVMANKQPLWNEATQVYQL 1002

  Fly  1374 DFGGRVTQESAKNFQIEFRGKQVMQFGRIDGNAYTLDFQYPFSALQAFAVALANVTQRLK 1433
            |||||||||||||||||..|:|||||||||||||.|||||||||:|||||||||||||||
Mouse  1003 DFGGRVTQESAKNFQIELEGRQVMQFGRIDGNAYILDFQYPFSAVQAFAVALANVTQRLK 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tusp	NP_001263014.1	WD40	51..>295	CDD:225201
		WD40	81..359	CDD:295369
		WD40 repeat	91..126	CDD:293791
		WD40 repeat	132..168	CDD:293791
		WD40 repeat	173..208	CDD:293791
		WD40 repeat	216..263	CDD:293791
		WD40 repeat	270..333	CDD:293791
		Tub	<588..>644	CDD:279506	36/58 (62%)
		Tub	<1355..1426	CDD:279506	59/70 (84%)
Gm2808	XP_017173259.1	PHA03247	<518..826	CDD:223021	55/320 (17%)
Gm2808	XP_017173259.1	Tub	<985..1055	CDD:366500	59/69 (86%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010