Protein Alignment dsd and KEL2

DIOPT Version :10

• Sequence 1: NP_651571.3
• Gene: dsd / 43315
• FlyBaseID: FBgn0039528
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_011754.3
• Gene: KEL2 / 853153
• SGDID: S000003470
• Length: 882
• Species: Saccharomyces cerevisiae
• Alignment Length: 395
• Identity: 92/395 - (23%)
• Similarity: 154/395 - (38%)
• Gaps: 85/395 - (21%)

  Fly   293 WSTVHPKHSPAPAGSASHGATIWRDTLHIVGGESYGRGKLMSTYDFNGNVWETVHPEDGS----- 352
            |:.|..|:||.|....|....:..|....|.|..:.:    |.|   |:||:.....||:
Yeast    73 WNRVKLKNSPFPRYRHSSSFIVTNDNRIFVTGGLHDQ----SVY---GDVWQIAANADGTSFTSK 130

  Fly   353 ------EVPDKRYGASTVMYGDKIFMYGG----VVKGHGISNELWAFDVSARTWA---NISVRAD 404
                  ..|..|.|.::.:.|:...::||    :.|...:.::|:.|::::..|.   .|..|
Yeast   131 RIDIDQNTPPPRVGHASTICGNAYVVFGGDTHKLNKNGLLDDDLYLFNINSYKWTIPQPIGRR-- 193

  Fly   405 PSCNATGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFAS---- 465
                          ||...||..:::.    .|..|..:.:||...:..|.|.:..|:.:|
Yeast   194 --------------PLGRYGHKISIIA----SNPMQTKLYLFGGQVDETYFNDLVVFDLSSFRRP 240

  Fly   466 -REWRIVPTTGYVVKGGYGHS-AAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLL 528
             ..|..:...|.:......|: .|||   .|::|:||     |:.:.:|:..|.|:||...||.:
Yeast   241 NSHWEFLEPVGDLPPPLTNHTMVAYD---NKLWVFGG-----ETPKTISNDTYRYDPAQSEWSKV 297

  Fly   529 SAA---PSARLLHTANFVNQGLMMVFGG-NTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHP-MP 588
            ...   |.....| |:.|.:.||.|.|| :|||         .||.|:...::....|:..| |.
Yeast   298 KTTGEKPPPIQEH-ASVVYKHLMCVLGGKDTHN---------AYSNDVYFLNLLSLKWYKLPRMK 352

  Fly   589 GHLQADLARFGHS-SVVFEESLYIYGG----FNGQLLNDMLRYQ----PGYCSYYTKQEKCTAAR 644
            ..:..:  |.||| :::..|.|.|.||    :....::|:...:    .|...|...........
Yeast   353 EGIPQE--RSGHSLTLMKNEKLLIMGGDKTDYASPNIHDLQTSETDQGEGTLLYTLDLSSLNELC 415

  Fly   645 PGVKC 649
            ||:.|
Yeast   416 PGIMC 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_651571.3	CUB	86..212	CDD:238001
		NanM	<288..391	CDD:442289	26/112 (23%)
		KELCH repeat	308..349	CDD:276965	9/40 (23%)
		NanM	343..614	CDD:442289	70/300 (23%)
		KELCH repeat	358..420	CDD:276965	11/68 (16%)
		KELCH repeat	424..474	CDD:276965	11/54 (20%)
		KELCH repeat	482..531	CDD:276965	16/49 (33%)
		KELCH repeat	535..588	CDD:276965	16/54 (30%)
		PSI	821..870	CDD:396154
		EGF_Lam	948..994	CDD:238012
		EGF_Lam	995..1040	CDD:238012
KEL2	NP_011754.3	NanM	77..391	CDD:442289	85/360 (24%)
		KELCH repeat	142..190	CDD:276965	9/47 (19%)
		KELCH repeat	257..308	CDD:276965	17/58 (29%)
		KELCH repeat	310..353	CDD:276965	17/52 (33%)
		SMC_N	<603..872	CDD:481474