DRSC/TRiP Functional Genomics Resources

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Protein Alignment dsd and ATRN

DIOPT Version :10

Sequence 1:NP_651571.3 Gene:dsd / 43315 FlyBaseID:FBgn0039528 Length:1323 Species:Drosophila melanogaster
Sequence 2:NP_647537.1 Gene:ATRN / 8455 HGNCID:885 Length:1429 Species:Homo sapiens


Alignment Length:1490 Identity:526/1490 - (35%)
Similarity:730/1490 - (48%) Gaps:312/1490 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 RRKCLLLL------TLLLFHGC----------FSGLHRAAAFNC---TAHGGRCQNDGQCQEDGQ 71
            |.:.||||      .|||...|          .||...|.|..|   ..:|||| |.|    .||
Human    58 RPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAVSGSAAAEAKECDRPCVNGGRC-NPG----TGQ 117

  Fly    72 CLCADGWQGPECQFCGGKVRMYHPMGTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTAN 136
            |:|..||.|.:||.|||:.|:....|.:.||.|||....||:|||:.:           |:|.  
Human   118 CVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQ-----------PNRI-- 169

  Fly   137 IRIHLREFATECGWDHLYIYDGDSVDSPLLAVFSGLMYRGNFSIRRVPQVIATSGTALVHFFSDD 201
            :|:....|||||.|||||:|||||:.:||:|.||||:.........||:|:||||.||:|||||.
Human   170 MRLRFNHFATECSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDA 234

  Fly   202 AYNMSGFNLTYKMNSCPSDSDEVECSGHGKCRDG------DCICDPMYRGEACNIAACPNNCFES 260
            |||::|||:||..:.||::     |||.|:|:..      :|.|...::||||:|..|.:|| ..
Human   235 AYNLTGFNITYSFDMCPNN-----CSGRGECKISNSSDTVECECSENWKGEACDIPHCTDNC-GF 293

  Fly   261 KNQGHCRLDQER-CSCYEGFAGDDCS-QISAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVG 323
            .::|.|.....| |||:..:.|..|| .:.|:.::.| ..::|......|||.|.:..:.:.:||
Human   294 PHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWT-REEYSNLKLPRASHKAVVNGNIMWVVG 357

  Fly   324 GESYGRG--KLMSTYDFNGNVWETVHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVKGHG-ISNE 385
            |..:...  .::..||.....|..::....:.|  .|||.|..:|.|||:||||.:...| ::||
Human   358 GYMFNHSDYNMVLAYDLASREWLPLNRSVNNVV--VRYGHSLALYKDKIYMYGGKIDSTGNVTNE 420

  Fly   386 LWAFDVSARTWANISVRADPSCNATGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSP 450
            |..|.:...:|..::.:|...             ..||||:|.:|.   .||....|:|||||.|
Human   421 LRVFHIHNESWVLLTPKAKEQ-------------YAVVGHSAHIVT---LKNGRVVMLVIFGHCP 469

  Fly   451 NYGYLNTVQEFNFASREWRIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRL 515
            .|||::.|||::.....|.|:.|.|.:|:||||||:.||..|..:||:||..:.|.:...|:..|
Human   470 LYGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDL 534

  Fly   516 YAYEPATRVWSLLSAAPSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCD 580
            |.|:..|::|::|..:...|.||||..|: |.|:|||||||||||.|:||||:|.|.:.||:.||
Human   535 YRYDVDTQMWTILKDSRFFRYLHTAVIVS-GTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACD 598

  Fly   581 SWHYHPMPGHLQADLARFGHSSVVFEESLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARP 645
            .|...|.| .|..|:.|||||:|:...::|::||||..||:|:|.:....|..:..:..|.||.|
Human   599 RWSVLPRP-DLHHDVNRFGHSAVLHNSTMYVFGGFNSLLLSDILVFTSEQCDAHRSEAACLAAGP 662

  Fly   646 GVKCIWDVQKMRCIAITQVQRSAIYGREQYDYVACPSKSRLTLTSELLHDVHRCQELASCQSCVS 710
            |::|:|:....:||:      .|:...||.:.:.....|:.||.    ||  ||.:...|.||.:
Human   663 GIRCVWNTGSSQCIS------WALATDEQEEKLKSECFSKRTLD----HD--RCDQHTDCYSCTA 715

  Fly   711 TAFGCTYCGNGVC--SKERCRETTSMASVFFESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSV 773
            ....|.:| |..|  ....|.|  ...|:|                   ..::||......   .
Human   716 NTNDCHWC-NDHCVPRNHSCSE--GQISIF-------------------RYENCPKDNPMY---Y 755

  Fly   774 CDQLHNCRACSANLACRWDSEHNRC---------------------------------------- 798
            |::..:||:|:.:..|:|:..:..|                                        
Human   756 CNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLVGNSCLKITTAKENYDNAKLFCRNHN 820

  Fly   799 ----------------------------------------KSYTSY------------------- 804
                                                    |...||                   
Human   821 ALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPS 885

  Fly   805 ----------------------------GGLALNRTQDEVA--CSPSCASLTNCQNCT--EDECI 837
                                        .|....|..:..|  |...||..|.|.:||  ..||:
Human   886 EPSDAGFCGILSEPSTRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGDCTSGSSECM 950

  Fly   838 WCQNEQRCVDRNAYTASFPYGQCREWTTFTAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMC 902
            ||.|.::|||.|||.||||:|||.||.|.:    :.|.::               |..|.:|..|
Human   951 WCSNMKQCVDSNAYVASFPFGQCMEWYTMS----TCPPEN---------------CSGYCTCSHC 996

  Fly   903 LDDPACGWCDNGSNTGLGRCVVGGALAP-----------------YDDTEC---ALKHWFFTSCP 947
            |:.|.||||.:.||||.|:|:.|....|                 .:.:.|   :..:|.|..||
Human   997 LEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCP 1061

  Fly   948 RCNCNGHSYCNDQQHCEQPCNNLTTGAHCEKCRTGYWGNPINGGKCQRCDCNGQGVYCHPDTGKC 1012
            .|.|||||.|.:|..||: |.|||||.|||.|.:|::|:|.||||||.|.|||....|:.:||||
Human  1062 ACQCNGHSKCINQSICEK-CENLTTGKHCETCISGFYGDPTNGGKCQPCKCNGHASLCNTNTGKC 1125

  Fly  1013 FCTTKGIVGDHCEKCDSQNHYHGDPLKGSCYYELTIDYQFTFNLSKKEDRHFTQINFRNSPGKPE 1077
            ||||||:.||.|:.|:.:|.|.|:||:|:|||.|.|||||||:||:::||::|.|||..:|.:..
Human  1126 FCTTKGVKGDECQLCEVENRYQGNPLRGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQN 1190

  Fly  1078 IDADFTITCSVPAKMDI------SVKRAGSPDMLILVGVNCSTFRHRFPKTDYQFGHSPDDNSSL 1136
            .|.|..|..|....::|      |.......:|.::...|...::..|....:.|.:.|:     
Human  1191 RDLDMFINASKNFNLNITWAASFSAGTQAGEEMPVVSKTNIKEYKDSFSNEKFDFRNHPN----- 1250

  Fly  1137 TTFYVFVHDFQPPIWIQIAFSQYPK-LNLQQFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQR 1200
            .||:|:|.:|..||.|||||||:.. ::|.|||:||.||||.|||:|||:|||||.....|||::
Human  1251 ITFFVYVSNFTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQ 1315

  Fly  1201 LFVEMEQMASRPFSQVLVDIE-NRESIDLSLTLEGIGHLSKKRKKECPSPIALEPCSGNRAAVLS 1264
            |..||:|||||||:.|.|.:| :.|..||      ||    ...|..|.|||||||.||:|||||
Human  1316 LLREMQQMASRPFASVNVALETDEEPPDL------IG----GSIKTVPKPIALEPCFGNKAAVLS 1370

  Fly  1265 LLVRLPTGGLSQAPSGQSAGLAVASALVTLGNPRRPSIDQHPKEPKSKRKQS--QHPDSC 1322
            :.||||.|.....|.||| |||||||||.: :.:.|.:.:........|||.  ..|.:|
Human  1371 VFVRLPRGLGGIPPPGQS-GLAVASALVDI-SQQMPIVYKEKSGAVRNRKQQPPAQPGTC 1428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsdNP_651571.3 CUB 86..212 CDD:238001 60/125 (48%)
NanM <288..391 CDD:442289 31/105 (30%)
KELCH repeat 308..349 CDD:276965 10/42 (24%)
NanM 343..614 CDD:442289 110/271 (41%)
KELCH repeat 358..420 CDD:276965 19/62 (31%)
KELCH repeat 424..474 CDD:276965 21/49 (43%)
KELCH repeat 482..531 CDD:276965 19/48 (40%)
KELCH repeat 535..588 CDD:276965 32/52 (62%)
PSI 821..870 CDD:396154 27/50 (54%)
EGF_Lam 948..994 CDD:238012 27/45 (60%)
EGF_Lam 995..1040 CDD:238012 24/44 (55%)
ATRNNP_647537.1 CUB 132..247 CDD:238001 62/127 (49%)
NanM 329..634 CDD:442289 124/325 (38%)
KELCH repeat 341..382 CDD:276965 10/40 (25%)
KELCH repeat 392..441 CDD:276965 19/48 (40%)
KELCH repeat 448..496 CDD:276965 21/50 (42%)
KELCH repeat 501..550 CDD:276965 19/48 (40%)
KELCH repeat 554..609 CDD:276965 33/56 (59%)
CLECT_attractin_like 788..920 CDD:153067 4/131 (3%)
PSI 932..983 CDD:396154 27/54 (50%)
EGF_Lam 1062..1107 CDD:238012 27/45 (60%)
EGF_Lam 1108..1153 CDD:238012 24/44 (55%)

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