DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dsd and atrn

DIOPT Version :9

Sequence 1:NP_001263013.1 Gene:dsd / 43315 FlyBaseID:FBgn0039528 Length:1323 Species:Drosophila melanogaster
Sequence 2:NP_001340891.1 Gene:atrn / 794975 ZFINID:ZDB-GENE-090312-21 Length:1383 Species:Danio rerio


Alignment Length:1476 Identity:513/1476 - (34%)
Similarity:724/1476 - (49%) Gaps:308/1476 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 LTLLLFHGCFSGLHRAAAFNCTAHGGRCQN---DGQCQ-EDGQCLCADGWQGPECQFCGGKVRMY 93
            |..|||....|||.|..|   ......|..   :|||. ..|.|:|..||.|.:||.|||:.|:.
Zfish    29 LRSLLFITALSGLLRLPA---ATEAKECDKPCLNGQCSAASGACVCETGWVGEQCQHCGGRFRLT 90

  Fly    94 HPMGTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIYDG 158
            .|.|.:.||.|||....||:|||:.:           |:  :.:|:....|||||.|||||:|||
Zfish    91 GPSGYLSDGPGNYKYKTKCTWLIEGQ-----------PN--SILRLRFEHFATECSWDHLYVYDG 142

  Fly   159 DSVDSPLLAVFSGLMYRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCPSDSDE 223
            ||:.|||||.||||:...::|...||:|:|.||..|:|||||.|||::|||::|::|:||::   
Zfish   143 DSIYSPLLAAFSGLIVPESYSNETVPEVVAHSGFTLLHFFSDAAYNLTGFNISYRLNTCPNN--- 204

  Fly   224 VECSGHGKCRDGD------CICDPMYRGEACNIAACPNNC-FESKNQGHCRLDQERCSCYEGFAG 281
              ||..|:||.|:      |:|:..::||||::..|.::| |..:  |.|....:||.|..|:.|
Zfish   205 --CSDRGECRVGNSSESVQCVCEDGWKGEACDVPYCSSDCGFPLR--GQCHNSTKRCLCKPGWQG 265

  Fly   282 DDCS-QISAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVGGE--SYGRGKLMSTYDFNGNVW 343
            .||| .:.|:.::.| ..::|......|||.|.:..|.:.::||.  :|...::::.::.:...|
Zfish   266 LDCSITVPANVSFWT-REEYSGYGLVRASHKAVVHEDVMWVIGGHVFNYTHYQMVTAFNISSQSW 329

  Fly   344 ET----VHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVKGHG-ISNELWAFDVSARTWANISVRA 403
            .|    ||...|      |||.|..::.|||:||||.:...| :::|||.|....::|..:|.||
Zfish   330 MTLNRSVHSVTG------RYGHSLSVHEDKIYMYGGKIDSTGNVTSELWVFHTRNQSWVLLSPRA 388

  Fly   404 DPSCNATGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFASREW 468
            ...             ..||||:|..|....| .:...::|:|||.|.|||::.||::|.....|
Zfish   389 KEQ-------------YAVVGHSAHTVQLNPD-GSEPVILVVFGHCPLYGYISQVQQYNIVKNTW 439

  Fly   469 RIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLSAAPS 533
            .::.|.|.:|:||||||:.||..|..:|::||..:.:.:...|:..||.|:...|.|.:|..:..
Zfish   440 SVLETRGALVQGGYGHSSVYDPQTRSIYIHGGYKAFTANKYGLAGDLYRYDVDERKWLILRDSGF 504

  Fly   534 ARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQADLARF 598
            .|.|||| .:..|.::|||||||||||.|:||||:|.|.:.|::.||.|...|.| .|..|:.||
Zfish   505 FRYLHTA-VIAGGNILVFGGNTHNDTSMSHGAKCFSSDFIAYNLACDEWTVLPNP-DLYHDVNRF 567

  Fly   599 GHSSVVFEESLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCIWDVQKMRCI---A 660
            |||:|.....:|:|||||..:|.|:||:.|..|:.:::..:|..|.|||||:|:.....|:   |
Zfish   568 GHSAVYHNGVMYVYGGFNSLMLGDVLRFTPASCAAFSEHLECVTAVPGVKCVWNSSTSTCVPWDA 632

  Fly   661 ITQVQRSAIYGREQYDYVACPSKSRLTLTSELLHDVHRCQELASCQSCVSTAFGCTYCGN-GVCS 724
            ...:...|:               |.|.:.....|..:|::.:.|.||.:....|.:|.. .|.|
Zfish   633 AALLDMEAL---------------RNTCSPRGYADGEKCEQYSDCYSCTANTNSCQWCSTLCVSS 682

  Fly   725 KERCRETTSMASVFFESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLAC 789
            ...|                     .|.|......::||....   ||||.:..:|::|:.:..|
Zfish   683 HSNC---------------------TSSPGGIMEYEACPKDNP---SSVCSKRTSCKSCATDQNC 723

  Fly   790 RWDSEHNRC-------------------------------------------------------- 798
            :|::.:..|                                                        
Zfish   724 QWETRNQECTTLPGNICGESWHLVGNSCLKLMTAKDSYDNAKLVCRNQQAVLASLTTQKKVQFVL 788

  Fly   799 ---------------------KSYTSY-------------------------------------- 804
                                 |...||                                      
Zfish   789 KEMHNRSLQSKAVITPWVGLRKINVSYWCWEDMSPFTNSTLQWLPGEPSDAGFCGYLAEPTFNGL 853

  Fly   805 ----------GGLALNRTQDEV-ACSPSCASLTNCQNCT--EDECIWCQNEQRCVDRNAYTASFP 856
                      |.|....|...| .|...||..::|..||  ..||:||.|.::|||.|||..|||
Zfish   854 KAATCVNSVNGSLCERPTNHSVKQCRTPCALRSSCSECTSGSSECMWCSNMRQCVDSNAYVPSFP 918

  Fly   857 YGQCREWTTFTAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGR 921
            ||||.||.|.    .|.|.::               |..|.:|..|||.|.||||.:.||||.|:
Zfish   919 YGQCMEWYTM----NSCPPEN---------------CSGYKTCGHCLDQPGCGWCTDPSNTGRGQ 964

  Fly   922 CVVGGALAPYDD----------------------TECALK---HWFFTSCPRCNCNGHSYCNDQQ 961
            |:.|....|...                      :.|.::   :|.|..||.|.|||||.|.::.
Zfish   965 CIEGSYRGPVQTLFHAPSTSGPSILPAPQPMLNVSLCPVEGNYNWSFIQCPACQCNGHSSCVNES 1029

  Fly   962 HCEQPCNNLTTGAHCEKCRTGYWGNPINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEK 1026
            .||: |.:||||..||.|.:||:|:|.|||.||.|.|||....|:.:.||||||||||.||.|..
Zfish  1030 VCER-CEDLTTGKQCESCISGYYGDPTNGGSCQPCKCNGHASMCNSNNGKCFCTTKGIKGDRCHV 1093

  Fly  1027 CDSQNHYHGDPLKGSCYYELTIDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAK 1091
            |:.:|.|.|:||||:|||.|.|||||||:||:::||::|.|||..:|.:...|.|..|..|....
Zfish  1094 CEVENRYQGNPLKGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFN 1158

  Fly  1092 MDI-------SVKRAGSPDMLILVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPP 1149
            ::|       :..:||. ::.|:...|...|:..|....:.|    ..|::: ||||:|.:|..|
Zfish  1159 LNITWATSFAAGTQAGE-EIPIVSRSNIKEFKDSFSNEKFDF----RSNTNI-TFYVYVSNFTWP 1217

  Fly  1150 IWIQIAFSQYPK-LNLQQFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPF 1213
            |.|||||||:.. ::|.|||:||.||||.|||:|||:|||||.....|||::|..||:|||||||
Zfish  1218 IKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPF 1282

  Fly  1214 SQVLVDIE-NRESIDLSLTLEGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQA 1277
            :.:.|.:| :.|..||      ||    ...|..|.|||||||.||:|||||:.||||.|.....
Zfish  1283 ATINVALETDEEPPDL------IG----GNVKSVPKPIALEPCFGNKAAVLSIFVRLPRGPGGIP 1337

  Fly  1278 PSGQSAGLAVASALVTLGNPRRPSIDQHPKEPKSKRKQS-QHPDSC 1322
            |.||| |||||||||.:.........:.....:|:::|. ..|.:|
Zfish  1338 PPGQS-GLAVASALVDISQQMCLGYKEKSGGLRSRKQQPLAQPSTC 1382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsdNP_001263013.1 CUB 86..212 CDD:238001 61/125 (49%)
PLN02153 290..582 CDD:177814 103/298 (35%)
KELCH repeat 308..349 CDD:276965 12/46 (26%)
Kelch_5 355..391 CDD:290565 16/36 (44%)
KELCH repeat 358..420 CDD:276965 20/62 (32%)
KELCH repeat 424..474 CDD:276965 17/49 (35%)
KELCH repeat 482..531 CDD:276965 17/48 (35%)
KELCH repeat 535..588 CDD:276965 29/52 (56%)
PSI 821..870 CDD:279745 26/50 (52%)
EGF_Lam 948..994 CDD:238012 24/45 (53%)
EGF_Lam 995..1040 CDD:238012 24/44 (55%)
atrnNP_001340891.1 KELCH repeat 342..391 CDD:276965 20/48 (42%)
KELCH repeat 394..442 CDD:276965 19/48 (40%)
Kelch_4 453..496 CDD:315981 15/42 (36%)
KELCH repeat 506..563 CDD:276965 31/58 (53%)
Kelch_1 506..558 CDD:279660 29/52 (56%)
CLECT_attractin_like 740..869 CDD:153067 5/128 (4%)
PSI 881..932 CDD:307546 27/54 (50%)
EGF_Lam 1016..1061 CDD:238012 24/45 (53%)
EGF_Lam 1062..1107 CDD:238012 24/44 (55%)
CUB 83..197 CDD:238001 61/126 (48%)
BTB <291..440 CDD:333434 51/168 (30%)
KELCH repeat 291..335 CDD:276965 10/43 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 311 1.000 Domainoid score I1289
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 898 1.000 Inparanoid score I368
OMA 1 1.010 - - QHG49386
OrthoDB 1 1.010 - - D32816at33208
OrthoFinder 1 1.000 - - FOG0003093
OrthoInspector 1 1.000 - - otm24649
orthoMCL 1 0.900 - - OOG6_105013
Panther 1 1.100 - - LDO PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2068
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.980

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