Protein Alignment dsd and atrnl1a

DIOPT Version :10

• Sequence 1: NP_651571.3
• Gene: dsd / 43315
• FlyBaseID: FBgn0039528
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: XP_073776876.1
• Gene: atrnl1a / 792417
• ZFINID: ZDB-GENE-081028-60
• Length: 1400
• Species: Danio rerio
• Alignment Length: 1521
• Identity: 517/1521 - (33%)
• Similarity: 744/1521 - (48%)
• Gaps: 338/1521 - (22%)

  Fly    14 RSSTSP-------TFNAKYRRKCLLLLTLLLFH--GCFSGLH-RAAAFNCTAHGGRCQNDGQCQE 68
            ||..||       |.|.:     ..|.|.::|:  .|..|.: :....||..  |||.|
Zfish     5 RSRISPRCFMGCRTHNVR-----TYLFTFMVFYLLVCTEGSYSKTCDKNCIY--GRCVN------ 56

  Fly    69 DGQCLCADGWQGPECQFCGGKVRMYHPMGTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSR 133
             |.|:|..||.|.:||.|.|:.::....|::.||..||....||:|||:. :|:
Zfish    57 -GTCVCEQGWTGDQCQHCQGRFKLTESSGSLTDGPVNYKYKTKCTWLIEG-YPN----------- 108

  Fly   134 TANIRIHLREFATECGWDHLYIYDGDSVDSPLLAVFSGLMY---RGNFSIRRVPQVIATSGTALV 195
             |.:|:....|||||.|||:|::||||:.:||:||||||:.   :||   ..:|:|:.|||.||:
Zfish   109 -AVLRLRFNHFATECSWDHMYVFDGDSIYAPLVAVFSGLVVPETKGN---ETIPEVVTTSGYALL 169

  Fly   196 HFFSDDAYNMSGFNLTYKMNSCPSDSDEVECSGHGKCRDGD-------CICDPMYRGEACNIAAC 253
            |||||.|||::|||:.|.:||||::     |||||:|..|:       |.|:..::||||:|..|
Zfish   170 HFFSDAAYNLTGFNIFYSINSCPNN-----CSGHGRCTTGNSISSSVYCECERYWKGEACDIRYC 229

  Fly   254 PNNCFESKNQGHCRLDQER-CSCYEGFAGDDCS--QISAHGAWSTVHPKHSPAPAGSASHGATIW 315
            .::| .|.::|:|.|..|: |.|.:.:.|.|||  ..||...|...:.|......|.|||.|.:.
Zfish   230 WDDC-GSPDRGYCDLTGEKLCVCNDSWQGPDCSLKVPSAESYWFLPNVKPDGQSLGRASHKAVVH 293

  Fly   316 RDTLHIVGG--ESYGRGKLMSTYDFNGNVWETVHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVK 378
            ...:.::||  .:|...:::..|:...:.|:.| |.:|.  |.:|||.|..::.|.|:|:||.::
Zfish   294 GKLMWVIGGFTFNYSSFQMVMNYNLESSTWDVV-PINGG--PLQRYGHSLALHKDVIYMFGGKLE 355

  Fly   379 -GHG-ISNELWAFDVSARTWANISVRA-DPSCNATGGTTAMCGPLHVVGHTATLVPGYGDKNNYQ 440
             |.| :::|||.||..:|||   |:|. .|...|.        ...|.||||.:|   .:||...
Zfish   356 AGFGNVTDELWLFDTHSRTW---SLRTPSPGLQAQ--------QFAVEGHTAHIV---DNKNGEP 406

  Fly   441 YMVVIFGHSPNYGYLNTVQEFNFASREWRIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSES 505
            .|||:||:||.|.||:.|||:...:..|.:..|.|.:|:||||||:.||..:..:||:||..:..
Zfish   407 IMVVLFGYSPIYSYLSHVQEYKIRTNSWSVAETNGALVQGGYGHSSIYDSSSHSIYVHGGYKALP 471

  Fly   506 ESSQVLSSRLYAYEPATRVWSLLSAAPSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQ 570
            .|...|...||.|:..|..|.:|..:..||.||:|..:: |:::|||||||||||.|.||||:|.
Zfish   472 ASKHGLVDHLYRYQVHTHTWFILKESGLARYLHSAVLIS-GVLLVFGGNTHNDTSLSNGAKCFSS 535

  Fly   571 DLLVYDVYCDSWHYHPMPGHLQADLARFGHSSVVFEESLYIYGGFNGQLLNDMLRYQPGYCSYYT 635
            |.|.||:.||.|...|.|. |..|:.||||::||...|:||:|||:|.:.||:|.::|..|..:.
Zfish   536 DFLSYDIACDEWTVLPNPS-LHRDVNRFGHTAVVSNGSMYIFGGFSGVIQNDVLVFKPASCEAFI 599

  Fly   636 KQEKCTAARPGVKCIWDVQKMRCIAITQVQRSAIYGREQYDYV----ACPSKSRLTLTSELLHDV 696
            :::.|.:|.|||:|:|  .:.||              |.:|..    :.|:..|...|:..   .
Zfish   600 REDVCQSAGPGVRCVW--IENRC--------------EPWDSSHANDSVPASFRPARTNAA---D 645

  Fly   697 HRCQELASCQSCVSTAFGCTYCGNGVC--SKERCRETTSMASVFFESSTQMAVSTASPPLNAKHL 759
            .:||:.:.|.||.:....|.:|.:..|  |...|              |.:.|..|..|....:|
Zfish   646 KQCQQFSDCASCTANTNDCQWCEDKKCISSSSNC--------------TVLTVELARHPRGPLYL 696

  Fly   760 DSCP--ISEEYL-----------------------VSSVCDQLHNCRACSANLACRWDSEHNRC- 798
            :..|  :||..|                       ...||.:|.|||:||.|:.|:|:.:...|
Zfish   697 NPPPAMLSEHQLSIWKPGVRKNGQSIKNHTKCSIRSEQVCSKLVNCRSCSLNINCQWEPQQQECH 761

  Fly   799 --------KSYTSYGG--LALNRTQD--------------------------------------- 814
                    :.::..|.  |.||.:::
Zfish   762 ALPAHLCGEDWSQVGDACLRLNASKESYDNAQHYCKNLEGSIASLTSARQVEFILEELQKYQLQE 826

  Fly   815 -------------------------------------------------EVA------------- 817
                                                             |||
Zfish   827 RKLTPWVGLRKINVSYWGWEDASPFTASTLQWLPGEPSDSGFCAYLERAEVAGLKAKPCTANTEG 891

  Fly   818 ----------------CSPSCASLTNCQNCTED--ECIWCQNEQRCVDRNAYTASFPYGQCREWT 864
                            |...||..|.|.|||..  ||:||.:.:||||.|||..|||||||.||.
Zfish   892 LICEKPIVSPNLSVRPCKMPCALRTTCANCTSQAMECMWCSSTKRCVDSNAYVISFPYGQCLEWQ 956

  Fly   865 TFTAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGRCVVGGALA 929
              |..|                  .:..|..:.:|..||:.|.||||.:.::||.|:|:.|....
Zfish   957 --TGDC------------------GAQNCSGHRTCGQCLEQPDCGWCGDPTDTGQGQCIEGSYRG 1001

  Fly   930 P------------YDDTECALK---HWFFTSCPRCNCNGHSYCNDQQHCEQPCNNLTTGAHCEKC 979
            |            .|.:.|:.:   .|.:.:||.|.|||||.|.:...||| |.|||.|.||:.|
Zfish  1002 PMRSLSRQSRERVLDTSVCSREKGFDWAYITCPACQCNGHSTCVNGSVCEQ-CKNLTAGLHCQFC 1065

  Fly   980 RTGYWGNPINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEKCDSQNHYHGDPLKGSCYY 1044
            ..||:|:|.||||||.|.||.....||..:|||:|||||:.||.|:.|||:|.|.|:||:|:|||
Zfish  1066 LPGYYGDPTNGGKCQACRCNNHANVCHSSSGKCYCTTKGVKGDQCQLCDSENRYLGNPLRGTCYY 1130

  Fly  1045 ELTIDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAKMDIS---VKRAGS---PD 1103
            .|.|||||||:|.:::|:|:|.|||..:|.:...:.|.:|..|....::|:   ...||:   .:
Zfish  1131 NLLIDYQFTFSLLQEDDQHYTGINFMANPEETNKNLDMSINASNNFNLNITWSIGSTAGTISGEE 1195

  Fly  1104 MLILVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQYPK-LNLQQF 1167
            ..|:...|...:|..|....:.|..:|:     .||:|:|.:|..|:.|||:|||:.. ::|.||
Zfish  1196 FPIVSKTNIKEYRDSFSCETFSFLANPN-----ITFHVYVSNFSWPVKIQISFSQHSSIMDLVQF 1255

  Fly  1168 FITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIENRESIDLSLTL 1232
            |:||.||||.|||:|||:||:||.....|||::|..|.:|||||||:.|.|.:|..|  :....|
Zfish  1256 FVTFFSCFLSLLLVAAVVWKVKQTCWASRRREQLMRERQQMASRPFATVTVALEAPE--EEEELL 1318

  Fly  1233 EGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAGLAVASALVTLGNP 1297
            :|         :....|||:||||||.|||.:||:.||......:|.|| .|:.:||||:.....
Zfish  1319 QG---------QADAGPIAVEPCSGNSAAVQTLLMSLPRASSGVSPPGQ-CGITIASALIDASQQ 1373

  Fly  1298 RRPSIDQHPKEPKSKRKQ-SQHPDSC 1322
            |...........||:::| :.|..:|
Zfish  1374 RPGDFKDKALSLKSRKQQHAVHQGTC 1399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_651571.3	CUB	86..212	CDD:238001	56/128 (44%)
		NanM	<288..391	CDD:442289	33/106 (31%)
		KELCH repeat	308..349	CDD:276965	10/42 (24%)
		NanM	343..614	CDD:442289	116/273 (42%)
		KELCH repeat	358..420	CDD:276965	23/64 (36%)
		KELCH repeat	424..474	CDD:276965	21/49 (43%)
		KELCH repeat	482..531	CDD:276965	18/48 (38%)
		KELCH repeat	535..588	CDD:276965	30/52 (58%)
		PSI	821..870	CDD:396154	28/50 (56%)
		EGF_Lam	948..994	CDD:238012	26/45 (58%)
		EGF_Lam	995..1040	CDD:238012	24/44 (55%)
atrnl1a	XP_073776876.1	None