DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dsd and megf8

DIOPT Version :9

Sequence 1:NP_001263013.1 Gene:dsd / 43315 FlyBaseID:FBgn0039528 Length:1323 Species:Drosophila melanogaster
Sequence 2:XP_005158088.1 Gene:megf8 / 791154 ZFINID:ZDB-GENE-090730-1 Length:2870 Species:Danio rerio


Alignment Length:1792 Identity:383/1792 - (21%)
Similarity:564/1792 - (31%) Gaps:727/1792 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 CTAHG----GRCQNDGQCQEDGQCLCADGWQGPECQFC-------------------GGKVRM-- 92
            |..||    |.|.|     :.|||.|....|||.|:.|                   |..|.:  
Zfish  1219 CNGHGDPLQGFCHN-----QTGQCYCTHHTQGPHCESCLPGYYGDPRDNGTCFSQCQGRSVLLSS 1278

  Fly    93 -----------YHPMGTIHDGWGNYSVSVKCSWLIDAR-------------------HPHWNRRH 127
                       :|.....|.|.|.:.....|.|::...                   ||      
Zfish  1279 SVPLSLSSSLGWHGAVGGHGGVGGHGGLSHCLWVLSVSQDLAPCMPGQSCPPVALTWHP------ 1337

  Fly   128 NTNPSRTANIRIHLREFATECGWDHLYIYDG-------DSVDS--PLLAVFSGLMYRGNFSIRRV 183
                           :..|.|...::|::||       ..|.|  .|:..|.|       :.|..
Zfish  1338 ---------------DSHTHCTNSYVYVFDGLPRFLSNGVVHSHHNLIGAFCG-------TTRME 1380

  Fly   184 P-QVIATSGTALVHFFSD-DAYNMSGFNLTYKMNSCPSDS-DE-----VECSGHGKCRDGDCICD 240
            | .|.||||...|:|.:: .:....|||.::.:..|.:.| ||     .||....:|.:|.|.|.
Zfish  1381 PITVEATSGVVSVYFEANVTSGRAQGFNASFWVKRCGNGSTDEGTVISAECQAGAQCINGLCECP 1445

  Fly   241 PMYRGEACNIAACPNNCFESKNQGHCRLDQERCSCYEGFAGDDCSQISAHGA--WST-------V 296
            ....|..|:...||.:|...:.:|.|.::...|.|.||:||.|||.||...:  |.|       |
Zfish  1446 HGLGGPQCDRPVCPGSCGAEEGRGTCNMNLGLCVCTEGWAGSDCSSISDTDSLVWETLLDTQLSV 1510

  Fly   297 HPKH----------SPAPAGSASHGATIWRDTLHIVGGESYGRGKLMSTYDFN--GNVWETV--H 347
            :..|          ..:|.|      |:|     :.||.|...|.|.:.|.::  ...|..|  .
Zfish  1511 NKAHRFLRRMGHSLMSSPQG------TLW-----MYGGLSLSEGILGNVYRYSVADRRWTEVLTS 1564

  Fly   348 PEDGSEVPDKRY-GASTVMY------------GDKIFMYGGVVKGHGISNELWAFDVSARTWANI 399
            ..:.|.:|..|| .||.::|            .:.:|:.|||.| .|::|:.|..::.::.|...
Zfish  1565 SVEESSMPLPRYHHASALVYYQFPISGSHSATRNLMFVVGGVTK-EGVANDTWCLNLDSQEWKQY 1628

  Fly   400 SVRADPSCNATGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFA 464
            .....|.               |.|||.|:..|       ..:::|.|:||..|:.:.:.||:..
Zfish  1629 KSSVLPP---------------VAGHTLTVRKG-------SSVLLIGGYSPENGFNHHLLEFSPQ 1671

  Fly   465 SREWRIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLS 529
            |..|.|...||....|.|||||.|...|:.|||:||.....|:.:. |..||:.......||||.
Zfish  1672 SGNWTIALHTGTPPTGLYGHSAVYHEQTDAVYVFGGYRFHVEAVEP-SGELYSLYYPNLTWSLLV 1735

  Fly   530 AA----PSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPM--- 587
            .:    |.:|..|.|..| :..|::.||.|        |.:.||..:.:|.:.|::| ..|:   
Zfish  1736 PSQGNKPLSRFFHAAALV-KDTMVIVGGRT--------GEEDYSNTVSLYQINCNTW-IQPVSSV 1790

  Fly   588 --PGHLQADLARFGHSSVVFEESLYIYGGFNGQLLNDMLRY----QPGYCSYYTKQEKCTAARPG 646
              |.:....||     ..|:.:.|::.|||||..|...|..    .|  |......|.|.::.. 
Zfish  1791 GEPVNSSVSLA-----MTVWGDRLFLSGGFNGVTLGRFLTLSLPSDP--CILLPTPEACNSSTG- 1847

  Fly   647 VKCIWDVQKMRCIAITQVQRSAIYGREQYDYVACPSKSRLTLTSELLHDVHRCQELASCQSC--- 708
             .|:|      |       |......:..:.:.|  ...|:..|.......:|:.|.:|..|   
Zfish  1848 -SCVW------C-------RGTCASSDAAERLGC--TLGLSTCSPTPRSPDQCRRLKTCSECLAR 1896

  Fly   709 --------VSTAFGCTYCGNGVCSKERCRETTSMASVFFESSTQMAVSTASPPLNAKHLDSCPIS 765
                    |.:|..|.:|.|       |.|...::|         :||..|     :|  .|.|:
Zfish  1897 HPKTFSSPVQSALQCKWCTN-------CPEGACISS---------SVSCTS-----EH--DCRIN 1938

  Fly   766 E-EYLVSSVCD----QLHNCRACSANLACRWDSEHNR-----------------CKSYTSYGGLA 808
            : |..:||.|.    :..:|..|:|:..|.|..:..|                 |.||.     .
Zfish  1939 QREIFLSSNCTETSCEASDCPKCTASGKCMWTRQFKRTGETRRILSVNPTYDWTCFSYA-----L 1998

  Fly   809 LNRTQDEVACSP------SCASLTNCQNCTE--------DECIWCQNEQRCVDRNAYTASFPYGQ 859
            ||.:..:|..||      .|..:..|..|..        ..|:|....|:|:..:........||
Zfish  1999 LNVSPMQVESSPPMPCPEPCHEIKTCSQCLSSRGSDGGWQRCVWSMALQQCMSPSFVPLRCEAGQ 2063

  Fly   860 CREWTTFTAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGRCVV 924
            |....:....|                   |.||.....|..|:..|.||||......|.|||:.
Zfish  2064 CGRLLSDEDSC-------------------SPQCFQLTQCSQCISRPQCGWCAGRGGNGSGRCLQ 2109

  Fly   925 GG------ALAPYDDTECALKHWFFTSCP---RCNCNGHSYCNDQQHCE---------------- 964
            ||      ||.|..::.     |.|..||   .|: |||.:||..|.|.                
Zfish  2110 GGLNGVSEALCPQWNSS-----WSFLHCPEEDECS-NGHHHCNVTQDCHDLPEGYHCTCRQGYVL 2168

  Fly   965 -------QP---------------------------------------------------CNNLT 971
                   :|                                                   |.|.|
Zfish  2169 SSVSGQCEPVCAQGCVNGTCISPGICQCHFGFVGENCSSQCRCNKHSNCKSISQLDTCLECKNNT 2233

  Fly   972 TGAHCEKCRTGYWGNPING---------------------------------------------- 990
            .|.||:||:..:.|:.:.|                                              
Zfish  2234 KGQHCDKCKPLFVGSAMGGGMCRPCREFCRGNSDICLSKDEHNKAMENPKDYPLDRESIEQWATE 2298

  Fly   991 --------------------------------GKCQRCDCNGQGVYC--HPDTGKCFCTT----- 1016
                                            |||::|.|||....|  |..|| |.|..     
Zfish  2299 GPTEDHAVCVSCQNNSVGDKCESCLSGYFLLQGKCEKCQCNGHADTCNEHDGTG-CPCQNNTETS 2362

  Fly  1017 ----------KGIVGDHCEKCDSQNHYHGDPLKG-SCYYELTIDYQFTFN--------------- 1055
                      |......|.||  :..::|:|:.| .||.:..:|.:..|:               
Zfish  2363 SCLSSPQNDRKECYRQQCAKC--KESFNGNPVNGRQCYRQFNVDSECCFDPTSQVNCFHEPNIRN 2425

  Fly  1056 ----------------------------------LSKKEDRHFTQINFRNSPGKPEIDADFT--- 1083
                                              :|...|....|::.::.....:|:.:.|   
Zfish  2426 LLRGRTVFFSAQPKFTNVDIRVTIDVTFGEVEVYVSNSHDTFIVQVDRQSGVHTIKIEDEATSAT 2490

  Fly  1084 -------ITCSVPAKMDI------------SVKRAGS--------------------PDMLILV- 1108
                   :..:.|:.|.:            |.|..||                    |..:::| 
Zfish  2491 ASRGEKEVPLAPPSPMKVFANSSSALLGTLSAKLQGSEREVREERAEGLITYITVWKPQTVLIVR 2555

  Fly  1109 GVN---CSTFRHRFP--KTDYQF----GHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQYPKLNL 1164
            ||.   ..||.|...  |:...|    |...:.::..:...:|:...|..|            :|
Zfish  2556 GVRDRVVITFPHEVHSLKSSRFFIALRGVGTETHNGESQGLLFLRQDQAHI------------DL 2608

  Fly  1165 QQFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFV-EMEQMASRPFSQVLVDIENRE---- 1224
            ..||..|.|||.|.|.:..:|||:||..| |||.||..: ||.:||||||:::.|.:|..|    
Zfish  2609 FVFFSVFFSCFFLFLSVCVLLWKVKQFLD-FRREQRRHIQEMTKMASRPFAKLTVYLEPEEPQLV 2672

  Fly  1225 ---------SIDLS--------------------------------------LTLEGIG---HL- 1238
                     ::.|:                                      |.|.|..   || 
Zfish  2673 YLPSAGGGSAVSLAHVRTGKLGGMVMGQRGRPGALSYKHDPGTGTATHHHHHLALSGGNNGQHLP 2737

  Fly  1239 -----------------SKKRKKECPS-----------------------------PIALEPCSG 1257
                             :...:...||                             ||.|||...
Zfish  2738 LHYLNAHHYAPSSTANPTSHHQHHYPSSHGSYQHFCRSDPFLSQLMGFSYSSFKVGPITLEPTDD 2802

  Fly  1258 NRAAVLSLLVRLPTGGLSQAPSGQSAGLAVASALVTL 1294
            ..|.|.::|::||.|.|  ||:....|    ||||||
Zfish  2803 GMAGVATVLIQLPGGIL--APNRACLG----SALVTL 2833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsdNP_001263013.1 CUB 86..212 CDD:238001 33/187 (18%)
PLN02153 290..582 CDD:177814 86/331 (26%)
KELCH repeat 308..349 CDD:276965 10/44 (23%)
Kelch_5 355..391 CDD:290565 14/48 (29%)
KELCH repeat 358..420 CDD:276965 15/74 (20%)
KELCH repeat 424..474 CDD:276965 15/49 (31%)
KELCH repeat 482..531 CDD:276965 20/48 (42%)
KELCH repeat 535..588 CDD:276965 15/57 (26%)
PSI 821..870 CDD:279745 10/56 (18%)
EGF_Lam 948..994 CDD:238012 21/197 (11%)
EGF_Lam 995..1040 CDD:238012 16/61 (26%)
megf8XP_005158088.1 CUB 36..134 CDD:238001
PLN02153 211..>458 CDD:177814
Kelch_3 240..283 CDD:290151
Kelch_6 276..319 CDD:290672
KELCH repeat 277..326 CDD:276965
KELCH repeat 329..372 CDD:276965
Kelch_6 330..372 CDD:290672
KELCH repeat 380..429 CDD:276965
KELCH repeat 439..487 CDD:276965
PSI 931..982 CDD:279745
EGF_3 1088..1122 CDD:289699
Laminin_EGF 1169..1214 CDD:278482
EGF_Lam 1216..1265 CDD:238012 15/50 (30%)
CUB <1307..1413 CDD:294042 26/133 (20%)
Kelch_4 1518..1561 CDD:290154 11/53 (21%)
KELCH repeat 1575..1633 CDD:276965 14/58 (24%)
Kelch_3 1597..1643 CDD:290151 14/61 (23%)
KELCH repeat 1636..1676 CDD:276965 14/46 (30%)
Kelch_3 1646..1696 CDD:290151 19/56 (34%)
KELCH repeat 1689..1737 CDD:276965 20/48 (42%)
KELCH repeat 1745..1791 CDD:276965 15/55 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1388
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D32816at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.