DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsd and atrnl1b

DIOPT Version :9

Sequence 1:	NP_001263013.1	Gene:	dsd / 43315	FlyBaseID:	FBgn0039528	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_697655.4	Gene:	atrnl1b / 569196	ZFINID:	ZDB-GENE-030131-8092	Length:	1364	Species:	Danio rerio

Alignment Length:	1480	Identity:	528/1480 - (35%)
Similarity:	723/1480 - (48%)	Gaps:	334/1480 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LLLTLLLFHGCFSGLHRAAAFNCTAHGGRCQNDGQCQEDGQCLCADGWQGPECQFCGGKVRMYHP 95
            ::.:|:|...|...  :....||.:  |||.|       |.|:|..||.|.:||.|.|:.::..|
Zfish    30 VMFSLVLISDCSPS--KPCEKNCLS--GRCVN-------GSCVCDRGWVGDQCQHCQGRFKLTEP 83

  Fly    96 MGTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIYDGDS 160
            .|.:.||..||....||:|||:. :|:            |.:|:....|||||.|||:|:|||||
Zfish    84 SGYLTDGPINYKFKTKCTWLIEG-YPN------------AVLRLRFNHFATECSWDHMYVYDGDS 135

  Fly   161 VDSPLLAVFSGLM---YRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCPSDSD 222
            :.:||:||||||:   .:||   ..||:|...||.||:|||||.|||::||.:.|.:||||::
Zfish   136 IYAPLVAVFSGLIVPEVKGN---ETVPEVETNSGFALLHFFSDAAYNLTGFEIFYSINSCPNN-- 195

  Fly   223 EVECSGHGKCRDGD-------CICDPMYRGEACNIAACPNNCFESKNQGHCRLDQER-CSCYEGF 279
               |||||||..|:       |.|:..::||||:|..|.||| .|.:.|:|....|: |.|.:.:
Zfish   196 ---CSGHGKCSSGNSIASRVYCDCENFWKGEACDIPYCRNNC-GSPDHGYCDFSGEKLCVCNDSW 256

  Fly   280 AGDDCSQI--SAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVGGE--SYGRGKLMSTYDFNG 340
            .|.|||..  |....|.....|...|..|.|||.|.:....:.:|||.  :|...:::..|:...
Zfish   257 QGPDCSLTVPSTESYWIMSAMKPFGASLGRASHKAVVQEKVMWVVGGYTFNYSNFQMILNYNLES 321

  Fly   341 NVWETVHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVK--GHGISNELWAFDVSARTWANISVRA 403
            .:|.||....|   |..|||.|..:|.|.|:|:||.::  ...:::|||.|::.:.||    ::.
Zfish   322 GIWNTVPISSG---PLPRYGHSLALYRDDIYMFGGKLEMGASNVTDELWVFNIPSMTW----MQK 379

  Fly   404 DPSCNATGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFASREW 468
            .||..|.|...|      |.||:|.||.   ..|....||||||:|..|.|::.:||:|..:..|
Zfish   380 SPSVPAHGQVYA------VEGHSAHLVE---MDNGDVVMVVIFGYSSIYSYISNIQEYNIRTNTW 435

  Fly   469 RIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLSAAPS 533
            .:..|.|.:.:||||||:.||..::.|||:||..|...:...|...||.||..||.|::|..:..
Zfish   436 LVPETRGAIAQGGYGHSSVYDRGSKSVYVHGGYRSLPANKYGLVDDLYRYEVQTRTWTILRESGY 500

  Fly   534 ARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQADLARF 598
            .|.||::..:. |.:::||||||||||.|.||||:|.|.|.||:.||.|...|.| :|..|..||
Zfish   501 PRYLHSSVLLG-GTLLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKVLPKP-NLHRDANRF 563

  Fly   599 GHSSVVFEESLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCIWDVQKMRCI---- 659
            ||::|....|:|::|||:..||||:|.|:|..|..:..|::|.||.|||:|||  ::.||:
Zfish   564 GHTAVTSNGSMYVFGGFSSVLLNDVLIYRPPSCEAFLGQDRCEAAGPGVRCIW--KRGRCVSWEP 626

  Fly   660 AITQVQRSAIYGREQYDYVACPSKSRLTLTSELLHDVHRCQELASCQSCVSTAFGCTYCGNGVC- 723
            :.|.....|.:         ||:|:..        :..||...:.|.||.:...||.:|.:..|
Zfish   627 SFTNSATPAPF---------CPAKAAT--------EDERCYRFSDCTSCTANTNGCQWCDSKKCI 674

  Fly   724 -SKERCRETTSMASVFFESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANL 787
             :...|..|                        .|:...|||..|    .:|.::.||::||.||
Zfish   675 SALSNCTST------------------------VKNFTKCPIRNE----QICSKMANCKSCSLNL 711

  Fly   788 ACRWDSEHNRC------------------------------------------------------ 798
            :|:||.:...|
Zfish   712 SCQWDPQQQECHTLPAQLCGDGWSNVGEVCLQINSSRESFDNAQHYCKNLEGKIASLTTAKQVDF 776

  Fly   799 ----------------------KSYTSYGG-------------------------LALNRTQ--- 813
                                  |...||.|                         ..|.|.|
Zfish   777 VLEELQKHQQKGKKLSPWVGLRKFNVSYWGWEDESPFTNTSLQWLPGEPNDSGFCAYLERAQVSG 841

  Fly   814 ----------DEVAC-----SPS---------CASLTNCQNCTED--ECIWCQNEQRCVDRNAYT 852
                      |.:.|     ||:         |:..|.|.|||..  ||:||.:.:||||.|||.
Zfish   842 LRANPCTANTDGLICEKPVVSPNQNARPCKTPCSLRTTCDNCTSQAMECMWCGSTKRCVDSNAYV 906

  Fly   853 ASFPYGQCREWTTFTAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNT 917
            .|||||||.||.  ||.|                  .|..|....:|.:||:.|.||||.:.|||
Zfish   907 ISFPYGQCLEWQ--TADC------------------LSQNCSGLRTCGLCLEQPDCGWCGDPSNT 951

  Fly   918 GLGRCVVGGALAPYDDTE------------CALK---HWFFTSCPRCNCNGHSYCNDQQHCEQPC 967
            |.|:|:.|....|.....            |..:   .|.|..||.|.|||||.|.:...||| |
Zfish   952 GRGQCMEGSYRGPMKSPSRHSQDMVLETGLCPKERGFEWAFIQCPACQCNGHSTCVNVSMCEQ-C 1015

  Fly   968 NNLTTGAHCEKCRTGYWGNPINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEKCDSQNH 1032
            .|||||.|||.|..||:|:|.||||||.|.|||....||..|||||||||||.||.|:.|||:|.
Zfish  1016 RNLTTGLHCETCLPGYYGDPTNGGKCQACKCNGHANMCHELTGKCFCTTKGIKGDQCQLCDSENR 1080

  Fly  1033 YHGDPLKGSCYYELTIDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAKMDI--S 1095
            |.|:||:|:|||.|.|||||||:|.:::|:|:|.|||..:|.:...:.|.:|..|....::|  |
Zfish  1081 YLGNPLRGTCYYNLLIDYQFTFSLLQEDDQHYTAINFMATPEQTSKNLDMSINASNNFNLNITWS 1145

  Fly  1096 V-KRAGS---PDMLILVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAF 1156
            | ..||:   .::.|:...|...:|..|....:.|..:|:     .||||:|.:|..||.|||||
Zfish  1146 VGSTAGTISGEEIPIVSKTNIKEYRDSFSCEKFSFHSNPN-----ITFYVYVSNFSWPIKIQIAF 1205

  Fly  1157 SQYPK-LNLQQFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLV-- 1218
            ||:.. ::|.|||:||.||||.|||:|||:|||||.....|||::|..|.:|||||||:.|.|
Zfish  1206 SQHNSIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLMRERQQMASRPFASVAVAL 1270

  Fly  1219 DIENRESIDLSLTLEGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSA 1283
            |:...|...|...:||           .|.|:|:|||||.:||||::|:.||.......|.|||
Zfish  1271 DVGGTEGELLQGGIEG-----------PPKPVAVEPCSGGKAAVLTVLMCLPRVASGVPPPGQS- 1323

  Fly  1284 GLAVASALVTLGNPRRPSIDQHPKEPKSKRKQSQ-----------HPDSC 1322
            |:|:||||          ||...::|...:::||           |..:|
Zfish  1324 GIAIASAL----------IDTSQQKPMDFKEKSQGLKNRKALPPAHQGTC 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_001263013.1	CUB	86..212	CDD:238001	57/128 (45%)
		PLN02153	290..582	CDD:177814	110/295 (37%)
		KELCH repeat	308..349	CDD:276965	12/42 (29%)
		Kelch_5	355..391	CDD:290565	15/37 (41%)
		KELCH repeat	358..420	CDD:276965	21/63 (33%)
		KELCH repeat	424..474	CDD:276965	19/49 (39%)
		KELCH repeat	482..531	CDD:276965	21/48 (44%)
		KELCH repeat	535..588	CDD:276965	28/52 (54%)
		PSI	821..870	CDD:279745	28/59 (47%)
		EGF_Lam	948..994	CDD:238012	28/45 (62%)
		EGF_Lam	995..1040	CDD:238012	28/44 (64%)
atrnl1b	XP_697655.4	CUB	74..189	CDD:238001	58/130 (45%)
		DSL	<211..261	CDD:302925	18/50 (36%)
		KELCH repeat	286..332	CDD:276965	12/45 (27%)
		Kelch_3	298..344	CDD:290151	14/48 (29%)
		Kelch_5	333..373	CDD:290565	15/39 (38%)
		KELCH repeat	336..382	CDD:276965	16/49 (33%)
		KELCH repeat	449..498	CDD:276965	21/48 (44%)
		Kelch_4	449..495	CDD:290154	20/45 (44%)
		KELCH repeat	502..555	CDD:276965	29/54 (54%)
		Kelch_5	562..595	CDD:290565	17/32 (53%)
		CLECT_attractin_like	730..858	CDD:153067	9/127 (7%)
		PSI	873..922	CDD:279745	28/50 (56%)
		EGF_Lam	997..1042	CDD:238012	28/45 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	311	1.000	Domainoid score	I1289
eggNOG	1	0.900	-	-		E1_KOG1388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	898	1.000	Inparanoid score	I368
OMA	1	1.010	-	-		QHG49386
OrthoDB	1	1.010	-	-		D32816at33208
OrthoFinder	1	1.000	-	-		FOG0003093
OrthoInspector	1	1.000	-	-		otm24649
orthoMCL	1	0.900	-	-		OOG6_105013
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2833
SonicParanoid	1	1.000	-	-		X2068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870