DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsd and LanB2

DIOPT Version :9

Sequence 1:	NP_001263013.1	Gene:	dsd / 43315	FlyBaseID:	FBgn0039528	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster

Alignment Length:	1100	Identity:	198/1100 - (18%)
Similarity:	302/1100 - (27%)	Gaps:	497/1100 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 AFNCTAHGGRCQNDGQCQE-------DGQ----CLCADGWQGPECQFCGGKVRMYHPMGTIHDGW 103
            |.:..|.|.||:.:|...:       .|:    |.|.....||:|..|   :.:|:.:
  Fly   289 AISDIAVGARCKCNGHASKCVPSTGMHGERTLVCECRHNTDGPDCDRC---LPLYNDL------- 343

  Fly   104 GNYSVSVKCSWLIDARHPHWNRRHNT--NPSRTANIRIHLREFATECGWD-HLYIYDG------- 158
                              .|.|..:|  |..:..|    ....|.:|.:| :|:...|
  Fly   344 ------------------KWKRSTSTEVNECKACN----CNGLADKCFFDANLFNRTGHGGHCLD 386

  Fly   159 --DSVDSPLLAVFSGLMYRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSC-PSD 220
              ::.|.|     :....:.||.:|                  ||.|.::        .:| |..
  Fly   387 CRENRDGP-----NCERCKENFYMR------------------DDGYCVN--------CACDPVG 420

  Fly   221 SDEVECSGHGKCRDGDCICDPMYRGEACNIAACPNNCFESKNQGHCRLDQERCSCYEGFAGDDCS 285
            |..::|:.||||:     |.|...|:.|:  .|.||.::....| |    ::|.|..|
  Fly   421 SRSLQCNSHGKCQ-----CKPGVTGDKCD--RCDNNYYQFGPHG-C----QQCGCDSG------- 466

  Fly   286 QISAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVGGESYGRGKLMSTYDFNGNVWETVHPED 350
                        ..|...||.....|....::.:                              :
  Fly   467 ------------GSHQNTPACDTETGICFCKENV------------------------------E 489

  Fly   351 GSEVPDKRYGASTVMYGDKIFMYGGVVKGHGISNELWAFDVSARTWANISVRADPSCNATGGTTA 415
            |....:.:.|...:   ||...:|
  Fly   490 GRRCNECKPGFFNL---DKNNRFG----------------------------------------- 510

  Fly   416 MCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFASREWRIVPTTGYVVKG 480
             |.|....|||:..:.                 :|.|..::....||.....|
  Fly   511 -CTPCFCYGHTSECMT-----------------APGYSIVSVTSNFNKFKERW------------ 545

  Fly   481 GYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLSAAPSARLLHTANFVNQ 545
                 .|.|....:|.:                   .|...:|     |...:|:
  Fly   546 -----TAADLNQREVDI-------------------KYNQYSR-----SIGTTAQ---------- 571

  Fly   546 GLMMVFGGNTH----------NDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQADLARFGH 600
                   ||.|          .|...|     |::||             .....|...:|..|.
  Fly   572 -------GNEHVYFQAPDRFLGDQRAS-----YNRDL-------------KFKLQLVGQVANTGV 611

  Fly   601 SSVVFEE-----SLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCIWDVQKMRCIA 660
            |.|:.|.     ||.|:...||                                         |.
  Fly   612 SDVILEGAGSRISLPIFAQGNG-----------------------------------------IP 635

  Fly   661 ITQVQRSAIYGREQYDYVACPSKSR---LTLTSELLHDVHRCQELASCQSCVSTAFGCTYCGNGV 722
            ...|:.......|.:||...||:|.   |::.|.|                  ||.
  Fly   636 DQGVKEYTFRLHEHHDYQWQPSQSARGFLSILSNL------------------TAI--------- 673

  Fly   723 CSKERCRETTSMASVFFESSTQMAVS---TASPPLNAKHLDSCPISEEYLVSSVCDQL-----HN 779
                :.|.|.|:.........::..:   .|..|  |..::.|...|.|| ...|:..     |:
  Fly   674 ----KIRATYSVQGEAILDDVELQTAHRGAAGHP--ATWIEQCTCPEGYL-GQFCESCAPGYRHS 731

  Fly   780 ---------CRACS----ANLACRWDSEHNRCKSYTSYGGLALNRTQDEVACSPSCASLTNCQNC 831
                     |..|.    |::.   |||..||                      .|...|:..||
  Fly   732 PARGGPFMPCIPCDCHGHADIC---DSETGRC----------------------ICQHNTHGDNC 771

  Fly   832 TEDECIWCQNEQRCVDRNAYTASFPYGQCREWTTFTAKCRSAPIQSTALAVGSTTALSSAQC--G 894
              |:|                |...||.....|....|....|.....|.:...|.:.: :|  |
  Fly   772 --DQC----------------AKGFYGNALGGTPNDCKRCPCPNDGACLQINEDTVICT-ECPKG 817

  Fly   895 YYNS-CQMCLD----DP--------ACGWCDNGSN---TGLGRC--VVGGALAPYDDT------E 935
            |:.| |:.|.|    ||        .|..||...|   ..:|.|  ..|..|....:|      :
  Fly   818 YFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQ 882

  Fly   936 C---------ALKHWFFTSCPRCNCNGHSYCNDQQ---HCEQ-----PCNNLTTGAHCEKCRTGY 983
            |         ||.|   ..|.||:|.......|:|   .|:|     .|.....|..|.:|:.||
  Fly   883 CLSGHFGDPLALPH---GRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGY 944

  Fly   984 WGNPINGGKCQRCDCNGQGVY---CHPDTGKCFCTTKGIVGDHCEKCDSQNHYHGDPLKG 1040
            : |..:|..|:.|.|:..|.|   |...:|:|.| ..|::|..|::|  :|:::|...:|
  Fly   945 F-NIRSGNGCENCLCDPVGSYNSTCDRYSGQCHC-RPGVMGQRCDQC--ENYFYGFSSEG 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_001263013.1	CUB	86..212	CDD:238001	20/137 (15%)
		PLN02153	290..582	CDD:177814	34/301 (11%)
		KELCH repeat	308..349	CDD:276965	1/40 (3%)
		Kelch_5	355..391	CDD:290565	4/35 (11%)
		KELCH repeat	358..420	CDD:276965	5/61 (8%)
		KELCH repeat	424..474	CDD:276965	8/49 (16%)
		KELCH repeat	482..531	CDD:276965	6/48 (13%)
		KELCH repeat	535..588	CDD:276965	8/62 (13%)
		PSI	821..870	CDD:279745	10/48 (21%)
		EGF_Lam	948..994	CDD:238012	15/53 (28%)
		EGF_Lam	995..1040	CDD:238012	14/47 (30%)
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532	2/6 (33%)
		EGF_Lam	298..347	CDD:238012	12/76 (16%)
		Laminin_EGF	359..414	CDD:278482	14/89 (16%)
		EGF_Lam	414..458	CDD:214543	16/51 (31%)
		Laminin_EGF	461..511	CDD:278482	12/143 (8%)
		LamB	572..697	CDD:214597	35/214 (16%)
		TNFRSF	<721..848	CDD:304602	34/170 (20%)
		CRD2	724..771	CDD:276900	11/71 (15%)
		EGF_Lam	743..791	CDD:238012	17/90 (19%)
		Laminin_EGF	847..897	CDD:278482	12/52 (23%)
		Laminin_EGF	902..953	CDD:278482	14/51 (27%)
		Laminin_EGF	956..1004	CDD:278482	14/47 (30%)
		Laminin_EGF	1004..1050	CDD:278482
		V_Alix_like	1122..1443	CDD:187408
		Tar	1139..1521	CDD:223910
		BAR	1308..1469	CDD:299863
		vATP-synt_E	1474..>1629	CDD:304907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10574
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030