Protein Alignment dsd and Megf8

DIOPT Version :10

• Sequence 1: NP_651571.3
• Gene: dsd / 43315
• FlyBaseID: FBgn0039528
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_609180.3
• Gene: Megf8 / 34099
• FlyBaseID: FBgn0031981
• Length: 2892
• Species: Drosophila melanogaster
• Alignment Length: 1725
• Identity: 368/1725 - (21%)
• Similarity: 590/1725 - (34%)
• Gaps: 577/1725 - (33%)

  Fly    39 HGCFSGLHRAAAFNCTAHGGRCQNDGQCQ-EDGQCLCADGWQGPECQFC----------GGK--- 89
            |||.       ...|..||.  |:.|.|. .:|:|.|.|..||..|:.|          |||
  Fly  1300 HGCL-------PCECNGHGN--QDLGVCNVSNGECYCKDNTQGLNCELCAPGYYGDPRGGGKCYY 1355

  Fly    90 ---------------VRMYHPMGTIHDGWGNYSVSVK-CSWLIDARHPHWNRRHNTNPSRTANIR 138
                           :..|.   :....|| .|:.|| |.|::..:         |..:..:.::
  Fly  1356 QCESRGILTNIGKSAIGSYQ---SYRSPWG-ASLEVKECLWILQPK---------TLQAEKSLLQ 1407

  Fly   139 IHL--REFATECGWDHLYIYD------GDSVDSPLLAV----FSGLMYRGNFSIRRVPQVI-ATS 190
            :..  :..|.:|..:.:||||      |.:..:.||||    :|.            |::| |.|
  Fly  1408 LEFQWQSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCAPYSS------------PRIIEARS 1460

  Fly   191 GTALVHFFSDDAYNMSGFNLTYKMNSCPSDSDEVECSGHGKCRDGD--CICDPMYRGEACNIAAC 253
            ....||:.........|||..|.:.:|.:.|    |.....| |..  |:|...|.|.:|.|..|
  Fly  1461 SHVTVHYKQGSERRHFGFNALYSVMNCVAGS----CISPHIC-DAQQRCVCPAGYVGASCEIEIC 1520

  Fly   254 PNNCFESKNQGHCRLDQERCSCYE-GFAGDDCSQISAHG-------------AWSTVHPKHSPAP 304
            |:||...:.||.|..:..||.|.. .:||.||..:....             :.|..|.:.:...
  Fly  1521 PSNCNAKRMQGFCDTEYGRCICSNANYAGADCGTLVQRNHLVMTELFNTQLLSESLEHLRKTIPR 1585

  Fly   305 AG---SASHGATIWRDTLHIVGGESYGRGKL--MSTYDFNGNVW-----ETVHPEDGSEVPDKRY 359
            .|   :|....::|     :.||.|...|.|  ...:|...:.|     |:..|||  .:|..||
  Fly  1586 FGHSVNADRRGSLW-----MFGGYSPNHGPLNDFRQFDTKNSTWLQVTVESSTPED--RMPLGRY 1643

  Fly   360 GASTVMYGDK--IFMYGGVVKGHGISNELWAFDVSARTWANISVRADPSCNATGGTTAMCGPLHV 422
            ..::.:|..|  |::|||:.....:.|:.|.|.:..:.|:.|.|..:|    ......:..|..:
  Fly  1644 FHASEIYVKKQIIYIYGGIGANSQLLNDFWMFSIQNQRWSQIKVEVEP----PEADYEVDVPPPL 1704

  Fly   423 VGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFASREWRIVPTTGYVVKGGYGHSAA 487
            .|||.|.:    ....::.::::.|.|.|......:.|||..:..|:.:...|..:...|||::.
  Fly  1705 AGHTLTHI----RYQEHESLILLGGLSLNKSRPLELWEFNLDTGRWQQLAAVGARMPVLYGHTSV 1765

  Fly   488 YDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLL----------SAAPSARLLHTANF 542
            |...|..||::||..:|.:|:      |||.:.....|:.|          |..|.||..|:| .
  Fly  1766 YHQETNSVYLFGGYSTEPQSN------LYALDLQKLSWTELPSFRELNSPASLLPRARYFHSA-V 1823

  Fly   543 VNQGLMMVFGGNTH--NDTSQSYGAKCYSQDLLVYDVY-CDSWHYHPMPGHLQADLARFGH--SS 602
            ..:..|:::||.|.  |.|           |:|:..|| |:.|      ..|..|:...|.  :|
  Fly  1824 TTEHYMILYGGRTQPFNGT-----------DVLIAYVYACNQW------VRLTEDVELIGRVPAS 1871

  Fly   603 VVFEE--------SLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKC-IWDVQKMRC 658
            ...|:        ::|:.||::|...:          |:.||     ...|...| :|...|.:|
  Fly  1872 SYAEDMAIDPDTGAIYVIGGWDGSSTH----------SHVTK-----ITLPDDICQLWSNGKYQC 1921

  Fly   659 -----IAITQVQRSAIYGREQYDYVACPSKSR---LTLTSELLHD-----VHRCQELASCQSCVS 710
                 .:...:|.:..|....:.:...|..:.   |.:.:....|     ...|...|:|.:|::
  Fly  1922 RHYMGCSYCTIQNTYSYSSHCFSHGRTPCANHNGTLVVNNGAACDDDWMASRNCSSFATCGACLA 1986

  Fly   711 -------TAFGCTYCGN------------------------------GVCSKERCRETTSMASVF 738
                   .|..|.:|.:                              |:|...:|.: .|..|..
  Fly  1987 AWPTHQEVAPVCHWCDDCGIRGRCVPAGVDCGRRSAWCNKELSVGVLGLCPLPQCYQ-LSCESCM 2050

  Fly   739 FESSTQMA------VSTASPPLNAKH----LDSCPISEEYLVSSVCDQLHNCRACSA------NL 787
            .:.....|      |...:..|..|:    ::|||:.        |....||..|.:      :.
  Fly  2051 LQPQCNWARNELGTVECIAKELVEKNQYRVVESCPLP--------CHTYENCSLCLSQTPTQDHQ 2107

  Fly   788 ACRWDSEHNRCKSYTSYG--------GLALNRTQDEVACSPSCASLTNCQNCTED-ECIWCQNEQ 843
            .|:|.:..|.|.:.:|..        ||.|..::.: .|...|...|.|.:|.|. .|.||..|.
  Fly  2108 ECKWSTMLNLCLTPSSQPLLCAGGVCGLVLEASELQ-RCPEPCHVYTQCSSCLEHAHCGWCAREG 2171

  Fly   844 RCVDRNAYTASFPYGQCREWTTFTAKCRSAPIQSTA------------LAVGSTTALSSAQCGYY 896
            ...|          |.|.|..  ....:..|..||.            |......:....||...
  Fly  2172 FNGD----------GICTEGA--LEHKQEHPSGSTCDLIYASWRNDSQLTHADVVSWHYVQCPAE 2224

  Fly   897 NSC-----------QMCLD-DPACGW---CDNGSNTGLGR--------CVVGGALAPYDDTECAL 938
            |.|           :.|:| |.|.|:   |..|.....|.        ||.|..::| |..:|..
  Fly  2225 NECINGHHNCDTVSEQCIDLDTAVGYKCVCAQGYREEQGACLPVCSQGCVRGNCVSP-DQCQCDF 2288

  Fly   939 KHWFFTSCPRCNCNGHSYCNDQQHCE--QPCNNLTTGAHCEKCRTGYWGNPINGGKCQ------- 994
            .:.......:|.|||||.|......:  ..|:|.|.|..||||:..:.|||..|..||
  Fly  2289 GYVGANCSIQCLCNGHSNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGNPREGHACQPCLDYCH 2353

  Fly   995 -----------------------------------------------RCD--------------- 997
                                                           |||
  Fly  2354 GHSDVCVAYDADPAVFNMTRSELERILQEGPAYNATCLRCGNHTAGDRCDSCLTGYFRGSEDLHK 2418

  Fly   998 ------CNGQGVYCHPDTG-KC----------FCTTKGIVGDH---------CEKCDSQNHYHGD 1036
                  |:|.|..|.|.|| ||          .||..|  |.:         |.||  ::.|.|:
  Fly  2419 ECRPCQCHGHGNICDPVTGEKCNCANNTESDATCTAGG--GKNSAQLCWMVQCSKC--RDSYAGN 2479

  Fly  1037 PLKG-SCYYELTIDYQFTFN--------------------------------------------- 1055
            |..| .||.::|::.:..|:
  Fly  2480 PTDGHQCYKQITVESRMCFDAKPIEECKSKPAALKPGQTVFFVIQPRFMNVDIRIIIDVTQGELD 2544

  Fly  1056 --LSKKEDRHFTQINFRNSPG------------KPEIDADFTITCSVPAKMDISVKRAGSPDMLI 1106
              :|.::|....:.|  .:.|            .|:|..:..:..::|...::::::..||:..|
  Fly  2545 VFMSPQDDSFIVETN--ETTGYHEIFLDNRYNWGPKIKREHPLNVALPRHDNVTIQKLFSPERRI 2607

  Fly  1107 -----------LVGVN------------------------------------CST------FRHR 1118
                       .:|.|                                    |:|      .::|
  Fly  2608 GGGGLGGGGGERIGANTYYVPQLQDCKSHGGHNFIVKDQHAKDLSTHVTLNHCNTLLRLFGLKNR 2672

  Fly  1119 FPKTDYQFGHSPDDNSSLTTFYVFVH--DFQPPIWIQIAFSQ-YPKLNLQQFFITFSSCFLLLLL 1180
            ...|..|..|    |.|.|.|::.:.  ....|.:..:.|.| ...::|..||..|.|||.|.|.
  Fly  2673 LVLTLPQHAH----NLSATRFFIALRASSGPEPSYGSVVFRQDQLHIDLFVFFSVFFSCFFLFLA 2733

  Fly  1181 MAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVL-----VDIEN-------------RESID 1227
            :..::||:||..|:.|.|::..|||..:|.|||:|:.     :|:::             |:...
  Fly  2734 VCVIVWKVKQAADLRRARRQHVVEMLHLAKRPFAQIFLASNGLDMDSPQPTSSSSSARAMRQRAR 2798

  Fly  1228 LSLTL--------EGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAG 1284
            .:|.|        :.:.|.|.:|:......:|:||...|.|||.::.:.||  |.|:||    ..
  Fly  2799 QALLLQEQSAGDSQSVMHHSTRRQSSRIMMVAIEPTFDNLAAVGTVFISLP--GRSRAP----LS 2857

  Fly  1285 LAVASALVTLGNPRRPSIDQHPKEPKSKRKQSQHP 1319
            :|:.|.|::... :.|...:|....:..:..:.||
  Fly  2858 IALGSTLISYSR-QYPLNTRHFMRAQRGQNVANHP 2891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_651571.3	CUB	86..212	CDD:238001	34/167 (20%)
		NanM	<288..391	CDD:442289	28/127 (22%)
		KELCH repeat	308..349	CDD:276965	10/47 (21%)
		NanM	343..614	CDD:442289	74/300 (25%)
		KELCH repeat	358..420	CDD:276965	15/63 (24%)
		KELCH repeat	424..474	CDD:276965	11/49 (22%)
		KELCH repeat	482..531	CDD:276965	17/58 (29%)
		KELCH repeat	535..588	CDD:276965	15/55 (27%)
		PSI	821..870	CDD:396154	13/49 (27%)
		EGF_Lam	948..994	CDD:238012	19/47 (40%)
		EGF_Lam	995..1040	CDD:238012	22/85 (26%)
Megf8	NP_609180.3	CUB	33..141	CDD:238001
		NanM	<210..455	CDD:442289
		KELCH repeat	228..268	CDD:276965
		KELCH repeat	370..420	CDD:276965
		KELCH repeat	425..476	CDD:276965
		NanM	431..>630	CDD:442289
		KELCH repeat	480..540	CDD:276965
		EGF_3	1186..1222	CDD:463759
		EGF_Lam	1257..1302	CDD:238012	1/1 (100%)
		EGF_Lam	1304..1354	CDD:238012	17/51 (33%)
		KELCH repeat	1585..1638	CDD:276965	14/59 (24%)
		NanM	1596..1892	CDD:442289	82/334 (25%)
		KELCH repeat	1642..1685	CDD:276965	12/42 (29%)
		KELCH repeat	1760..1813	CDD:276965	17/58 (29%)
		KELCH repeat	1817..1867	CDD:276965	17/67 (25%)
		EGF_Lam	2299..2346	CDD:238012	19/46 (41%)
		EGF_Lam	2422..2487	CDD:238012	20/68 (29%)