Protein Alignment dsd and LanB1

DIOPT Version :10

• Sequence 1: NP_651571.3
• Gene: dsd / 43315
• FlyBaseID: FBgn0039528
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_476618.1
• Gene: LanB1 / 34068
• FlyBaseID: FBgn0261800
• Length: 1788
• Species: Drosophila melanogaster
• Alignment Length: 1174
• Identity: 226/1174 - (19%)
• Similarity: 336/1174 - (28%)
• Gaps: 451/1174 - (38%)

  Fly    52 NCTAHGGRC-----------QNDGQCQEDGQCLCADGWQGPECQFCGGKVRMYHPMGTIHDGWGN 105
            :|..|..:|           ..||...  |:|.|....:|..|:.|             .|.:.:
  Fly   289 SCYGHASQCLPLDPAFSQADNEDGMVH--GRCECTHNTKGMNCEEC-------------EDFFND 338

  Fly   106 YSVSVKCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIYDGDSVDSPLLAVF- 169
                  ..|     .|.:.::  ||..:......|    |..|.:|.              |||
  Fly   339 ------LPW-----KPAFGKK--TNACKKCECNDH----AVSCHFDE--------------AVFT 372

  Fly   170 -SGLM-----------YRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSC-PSDS 221
             ||.:           .||......:|           :|:.|...:::...:      | |.|.
  Fly   373 ASGFVSGGVCDNCLHNTRGQHCEECMP-----------YFYRDPEQDITSERV------CQPCDC 420

  Fly   222 DEVECSGHGKCRD----------GDCICDPMYRGEACN----------------IAACPNNCFES 260
            |....|..|.|..          |.|.|.....|..||                ...|..|...:
  Fly   421 DPQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGT 485

  Fly   261 KNQGHCRLDQERCSCYEGFAGDDCSQI--SAHGAWSTVHPKHSPAPAG----SASHGATIWRDTL 319
            .|...|.:....|.|.:...|.||:|.  ..:|.        |.:|.|    :...|.: :.:..
  Fly   486 LNNSGCVMRTGECKCKKYVTGKDCNQCMPETYGL--------SESPEGCSLCNCDAGGS-YDNYC 541

  Fly   320 HIVGGESYGR----GKLMS------------------------TYDFNGNVWETVHPEDGS---- 352
            .::.|:...|    |:..|                        :|..|||........|||
  Fly   542 DVISGQCRCRPHMTGRSCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGI 606

  Fly   353 ---EVPDKRYGASTVMYGD--KIFMYGGVVKGHGISNELW--AFDVSARTWANISVRADPSCNAT 410
               .||:......||  ||  :...|..|::....|...|  ||....|     ..:.||.
  Fly   607 GFTRVPENSELVFTV--GDIPRSMPYDAVIRYQSTSRGDWENAFITLVR-----PDQVDPE---- 660

  Fly   411 GGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFASREWRIVPTTG 475
            ||    ||.|.....:.|.:|                             |:...|..::|....
  Fly   661 GG----CGELAAATSSETRIP-----------------------------FSLPDRSRQVVALNE 692

  Fly   476 YVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLSAAPSARLL-HT 539
            ..::.|            |||.:               |:|.......|.|     |:|.:| .:
  Fly   693 VCLEAG------------KVYKF---------------RIYFERKRHDVDS-----PTATILVDS 725

  Fly   540 ANFVNQ-GLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQADLARFGHS-- 601
            ...:.: .:..:|.|:...|..:....| |:....:||:   ::...|...:|...|:.|.|.
  Fly   726 LTLIPRIDVTPIFQGSVLADIRKKDYEK-YNCKSSLYDM---NYKSDPKCQNLDNILSVFVHDGA 786

  Fly   602 -----------SVVFEESLYIYGGFNGQLLNDMLRYQ-----PG--------------------- 629
                       |.|.|.:    ||: .|...:::..|     ||
  Fly   787 SMCNCNPTGSLSKVCESN----GGY-CQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKD 846

  Fly   630 -YCSYYTKQEKCTAARPGVKC------IWDVQKMRCIAITQVQRSAIYGREQYDYVACPSKSRLT 687
             ||...|.|.:|.....|.:|      .|:..:.|                     .|.......
  Fly   847 KYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECR---------------------VCQCNGHAA 890

  Fly   688 LTSELLHDVHRCQELA---SCQSCVSTAFGCTYCGNGV-CSKERCRETTSMASVFFESSTQMAVS 748
            ....:......||:..   ||.||:...:|....|:.: |...||.||.:.
  Fly   891 TCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVAS-------------- 941

  Fly   749 TASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLACRWDSEHNRCKSYTSYGGLALNRTQ 813
                  ...|.|.|.:          |..:|...|.    |:.....:||
  Fly   942 ------GLAHADGCSL----------DTRNNNMLCH----CQEGYSGSRC--------------- 971

  Fly   814 DEVACSPSCASLTNCQNCTEDECIWCQNEQRCVDRNAYTASFPYGQCREWTTFTAKCRSAPIQST 878
             |:.......:..|...|::.||      ...||      .:..|.|...|....||
  Fly   972 -EICADNFFGNPDNGGTCSKCEC------SNNVD------LYDTGNCDRQTGACLKC-------- 1015

  Fly   879 ALAVGSTTALSSAQC--GYY-----NSCQMCLDDPACGWCD-NGSNTGLGRC-----------VV 924
               :..||......|  |::     .:||.|       .|| .|:|..:..|           .|
  Fly  1016 ---LYQTTGDHCELCKDGFFGDALQQNCQQC-------ECDFLGTNNTIAHCDRFTGQCPCLPNV 1070

  Fly   925 GGALAPYDDTECALKHWFFTS---CPRCNCNG----HSYCNDQQ-HCEQPCNNLTTGAHCEKCRT 981
            .|...    .:||..||...|   |..|||:.    |..||... .|:  |.....|..|.:|:.
  Fly  1071 QGVRC----DQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQ--CKPGFGGRACNQCQA 1129

  Fly   982 GYWGNPINGGKCQRCDCNGQGV---YCHPDTGKCFCTTKGIVGDHCEKCDSQNHY----HGDPLK 1039
            .|||||  ..|||.|:|:..|.   .|..:||.|.| .:||.|..|.:| ::.:.    |..|.
  Fly  1130 HYWGNP--NEKCQPCECDQFGAADFQCDRETGNCVC-HEGIGGYKCNEC-ARGYIGQFPHCSPC- 1189

  Fly  1040 GSCY 1043
            |.|:
  Fly  1190 GECF 1193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_651571.3	CUB	86..212	CDD:238001	20/138 (14%)
		NanM	<288..391	CDD:442289	28/145 (19%)
		KELCH repeat	308..349	CDD:276965	9/68 (13%)
		NanM	343..614	CDD:442289	54/296 (18%)
		KELCH repeat	358..420	CDD:276965	17/65 (26%)
		KELCH repeat	424..474	CDD:276965	5/49 (10%)
		KELCH repeat	482..531	CDD:276965	7/48 (15%)
		KELCH repeat	535..588	CDD:276965	9/54 (17%)
		PSI	821..870	CDD:396154	9/48 (19%)
		EGF_Lam	948..994	CDD:238012	17/50 (34%)
		EGF_Lam	995..1040	CDD:238012	15/51 (29%)
LanB1	NP_476618.1	Laminin_N	54..286	CDD:459653
		EGF_Lam	287..343	CDD:238012	13/79 (16%)
		Laminin_EGF	355..415	CDD:395007	14/94 (15%)
		Laminin_EGF	418..475	CDD:395007	11/56 (20%)
		EGF_Lam	477..526	CDD:238012	13/56 (23%)
		EGF_Lam	529..567	CDD:214543	5/38 (13%)
		EGF_Lam	789..834	CDD:214543	9/49 (18%)
		Laminin_EGF	837..885	CDD:395007	10/68 (15%)
		Laminin_EGF	883..930	CDD:395007	9/46 (20%)
		Laminin_EGF	933..988	CDD:395007	15/104 (14%)
		Laminin_EGF	991..1035	CDD:395007	13/66 (20%)
		Laminin_EGF	1043..1091	CDD:395007	13/58 (22%)
		Laminin_EGF	1094..1142	CDD:395007	19/51 (37%)
		Laminin_EGF	1142..1190	CDD:395007	15/50 (30%)
		Mplasa_alph_rch	1228..>1771	CDD:275316
		cc_DmLAMB1-like_C	1717..1786	CDD:411973