DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsd and Atrnl1

DIOPT Version :9

Sequence 1:	NP_001263013.1	Gene:	dsd / 43315	FlyBaseID:	FBgn0039528	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_008758809.2	Gene:	Atrnl1 / 307992	RGDID:	1563485	Length:	1377	Species:	Rattus norvegicus

Alignment Length:	1456	Identity:	523/1456 - (35%)
Similarity:	717/1456 - (49%)	Gaps:	309/1456 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LLFHG-----CFSGLHRAAAFNCTAHGGRCQNDGQCQE----DGQCLCADGWQGPECQFCGGKVR 91
            ||..|     |:..|: .|.:...:....|:..|.|..    :..|||..||.|.:||.|.|:.:
  Rat    34 LLLDGNSWLLCYGFLY-LALYAQVSQSKPCERTGSCFSGRCVNSTCLCDPGWVGDQCQHCQGRFK 97

  Fly    92 MYHPMGTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIY 156
            :..|.|.:.||..||....||:|||:. :|:            |.:|:....|||||.|||:|:|
  Rat    98 LTEPSGYLTDGPINYKYKTKCTWLIEG-YPN------------AVLRLRFNHFATECSWDHMYVY 149

  Fly   157 DGDSVDSPLLAVFSGLM---YRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCP 218
            ||||:.:||:||.|||:   .|||   ..||:|:.|||.||:|||||.|||::|||:.|.:||||
  Rat   150 DGDSIYAPLVAVLSGLIVPEVRGN---ETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINSCP 211

  Fly   219 SDSDEVECSGHGKCRDG-------DCICDPMYRGEACNIAACPNNCFESKNQGHCRLDQER-CSC 275
            ::     |||||||...       .|.||..::||||:|..|..|| .|.:.|:|.|..|: |.|
  Rat   212 NN-----CSGHGKCTTSVSVASQVYCECDKYWKGEACDIPYCKANC-GSPDHGYCDLTGEKLCVC 270

  Fly   276 YEGFAGDDCS--QISAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVGGE--SYGRGKLMSTY 336
            .:.:.|.|||  ..|....|...:.|......|.|||.|.:....:.::||.  :|...:::..|
  Rat   271 NDSWQGPDCSLNVPSTESYWILPNVKPFSPSVGRASHKAVLHGKFMWVIGGYTFNYSSFQMVLNY 335

  Fly   337 DFNGNVWETVHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVK--GHGISNELWAFDVSARTWANI 399
            :...::|.......|   |.:|||.|..:|.:.||||||.::  ...:::|||.|:|.:::|:.
  Rat   336 NLESSIWNVGAVSRG---PLQRYGHSLALYQENIFMYGGRMETSDGNVTDELWVFNVRSQSWST- 396

  Fly   400 SVRADPSCNATGGTTAMCGPLHVVGHTATLVP-GYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNF 463
               ..|:....|...|      |.||:|.::. ..||    ..|:||||:|..|||.:::||::.
  Rat   397 ---KTPTILGHGQQYA------VEGHSAHIMELDSGD----VVMIVIFGYSAIYGYTSSIQEYHI 448

  Fly   464 ASREWRIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLL 528
            :|..|.:..|.|.:|:|||||::.||.:|:.|||:||..:...:...|...||.||..:|.|::|
  Rat   449 SSNTWLVPETKGAIVQGGYGHTSVYDEMTKSVYVHGGYKALPGNKYGLVDDLYKYEVNSRTWTIL 513

  Fly   529 SAAPSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQA 593
            ..:..||.||:|..:: |.::|||||||||||.|.||||:|.|.|.||:.||.|...|.| :|..
  Rat   514 KESGFARYLHSAVLIS-GAVLVFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKTLPKP-NLHR 576

  Fly   594 DLARFGHSSVVFEESLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCIWDVQKMRC 658
            |:.|||||:||...|:||:|||:..||||:|.|:|..|..:..:|.|..|.||:||:|:  |..|
  Rat   577 DVNRFGHSAVVINGSMYIFGGFSSVLLNDILVYKPPSCKAFRDEELCRNAGPGIKCVWN--KNHC 639

  Fly   659 IAITQVQRSAIYGREQYDYVACPSKSRLTLTSELLHDVHRCQELASCQSCVSTAFGCTYCGNGVC 723
                   .|...|........||.:   |..|:     .||...|.|.||.:...||.:|.:
  Rat   640 -------ESWESGNANLLRAKCPPR---TAASD-----DRCYRYADCASCTANTNGCQWCDD--- 686

  Fly   724 SKERCRETTSMASVFFESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLA 788
              ::|...:|..|.                 :.::...|.|..|    .:|::|.:|::||.||.
  Rat   687 --KKCISASSNCST-----------------SVRNYTKCHIRNE----QICNKLTSCKSCSLNLN 728

  Fly   789 CRWDSEHNRCKS----------------------------------YTSYGGLALNRTQDEVA-- 817
            |:||.....|::                                  |...|.||...|..||.
  Rat   729 CQWDQRQQECQALPAHLCGEGWNHVGDSCLRINSSRESYDSAKLYCYNLSGNLASLTTSKEVGFV 793

  Fly   818 ----------------------------------------------------------------- 817

  Rat   794 LDEIQKNTQQRVSPWVGLRKINISYWGWEDMSPFTNTSLQWLPGEPNDSGFCAYLERAAVAGLKA 858

  Fly   818 -------------------------CSPSCASLTNCQNCTED--ECIWCQNEQRCVDRNAYTASF 855
                                     |...|:..|:|.|||.:  ||:||.:.:||||.|||..||
  Rat   859 NPCTSMADGLVCEKPVVSPNQNARPCKKPCSLRTSCANCTSNGMECMWCSSTKRCVDSNAYIISF 923

  Fly   856 PYGQCREWTTFTAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLG 920
            |||||.||.|.|.                    |...|....:|..||:.|.||||::.||||.|
  Rat   924 PYGQCLEWQTATC--------------------SPQNCSGLRTCGQCLEQPGCGWCNDPSNTGRG 968

  Fly   921 RCVVGGA-----LAPYDDTECALK----------HWFFTSCPRCNCNGHSYCNDQQHCEQPCNNL 970
            .|:.|.:     ||...::|.||.          .|.|..||.|.|||||.|.:...||| |.||
  Rat   969 YCIEGSSRGPMKLAGVHNSEVALDTSLCPKEKNYEWSFIQCPACQCNGHSTCINNNVCEQ-CKNL 1032

  Fly   971 TTGAHCEKCRTGYWGNPINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEKCDSQNHYHG 1035
            |||..|:.|..||:|:|.|||:|..|.|.|....||..|||||||||||.||.|:.|||:|.|.|
  Rat  1033 TTGRQCQDCMPGYYGDPTNGGQCTACTCGGHANVCHLHTGKCFCTTKGIKGDQCQLCDSENRYVG 1097

  Fly  1036 DPLKGSCYYELTIDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAKMDI--SVKR 1098
            :||:|:|||.|.|||||||:|.:::|||.|.|||..:|.:...:.|.:|..|....::|  ||..
  Rat  1098 NPLRGTCYYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDISINASNNFNLNITWSVGS 1162

  Fly  1099 AG----SPDMLILVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQY 1159
            .|    ..:..|:..:|...:|..|....:.|..:|:     .||||:|.:|..||.|||||||:
  Rat  1163 TGGTISGEETPIVSKMNIKEYRDSFSYEKFNFRSNPN-----ITFYVYVSNFSWPIKIQIAFSQH 1222

  Fly  1160 PK-LNLQQFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIE-N 1222
            .. ::|.|||:||.||||.|||:|||:|||||.....|||::|..|.:|||||||:.|.|.:| .
  Rat  1223 NTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVG 1287

  Fly  1223 RESID-LSLTLEGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAGLA 1286
            .|..| |...|||           .|.|||:|||:|||||||::.:.||.|.....|.||| |||
  Rat  1288 AEQTDFLRGPLEG-----------APKPIAIEPCAGNRAAVLTVFLCLPRGTSGAPPPGQS-GLA 1340

  Fly  1287 VASALVTLGNPRRPSIDQHPKEPKSK 1312
            :||||:.:.       .|.|.:.|.|
  Rat  1341 IASALIDIS-------QQKPSDNKDK 1359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_001263013.1	CUB	86..212	CDD:238001	59/128 (46%)
		PLN02153	290..582	CDD:177814	106/296 (36%)
		KELCH repeat	308..349	CDD:276965	9/42 (21%)
		Kelch_5	355..391	CDD:290565	16/37 (43%)
		KELCH repeat	358..420	CDD:276965	20/63 (32%)
		KELCH repeat	424..474	CDD:276965	18/50 (36%)
		KELCH repeat	482..531	CDD:276965	19/48 (40%)
		KELCH repeat	535..588	CDD:276965	30/52 (58%)
		PSI	821..870	CDD:279745	28/50 (56%)
		EGF_Lam	948..994	CDD:238012	25/45 (56%)
		EGF_Lam	995..1040	CDD:238012	27/44 (61%)
Atrnl1	XP_008758809.2	CUB	92..207	CDD:238001	60/130 (46%)
		DSL	<234..279	CDD:418607	18/45 (40%)
		KELCH repeat	304..352	CDD:276965	10/50 (20%)
		PLN02153	349..>615	CDD:177814	119/284 (42%)
		Kelch_5	351..391	CDD:404696	17/39 (44%)
		KELCH repeat	354..407	CDD:276965	19/56 (34%)
		KELCH repeat	520..573	CDD:276965	31/54 (57%)
		CLECT	746..872	CDD:413318	7/125 (6%)
		PSI	887..936	CDD:396154	27/48 (56%)
		EGF_Lam	1011..1056	CDD:238012	25/45 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1235
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	658	1.000	Inparanoid score	I742
OMA	1	1.010	-	-		QHG49386
OrthoDB	1	1.010	-	-		D32816at33208
OrthoFinder	1	1.000	-	-		FOG0003093
OrthoInspector	1	1.000	-	-		otm45612
orthoMCL	1	0.900	-	-		OOG6_105013
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2068
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980