DRSC/TRiP Functional Genomics Resources

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Protein Alignment dsd and Atrnl1

DIOPT Version :10

Sequence 1:NP_651571.3 Gene:dsd / 43315 FlyBaseID:FBgn0039528 Length:1323 Species:Drosophila melanogaster
Sequence 2:NP_001418043.1 Gene:Atrnl1 / 307992 RGDID:1563485 Length:1377 Species:Rattus norvegicus


Alignment Length:1456 Identity:523/1456 - (35%)
Similarity:717/1456 - (49%) Gaps:309/1456 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 LLFHG-----CFSGLHRAAAFNCTAHGGRCQNDGQCQE----DGQCLCADGWQGPECQFCGGKVR 91
            ||..|     |:..|: .|.:...:....|:..|.|..    :..|||..||.|.:||.|.|:.:
  Rat    34 LLLDGNSWLLCYGFLY-LALYAQVSQSKPCERTGSCFSGRCVNSTCLCDPGWVGDQCQHCQGRFK 97

  Fly    92 MYHPMGTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIY 156
            :..|.|.:.||..||....||:|||:. :|:            |.:|:....|||||.|||:|:|
  Rat    98 LTEPSGYLTDGPINYKYKTKCTWLIEG-YPN------------AVLRLRFNHFATECSWDHMYVY 149

  Fly   157 DGDSVDSPLLAVFSGLM---YRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCP 218
            ||||:.:||:||.|||:   .|||   ..||:|:.|||.||:|||||.|||::|||:.|.:||||
  Rat   150 DGDSIYAPLVAVLSGLIVPEVRGN---ETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINSCP 211

  Fly   219 SDSDEVECSGHGKCRDG-------DCICDPMYRGEACNIAACPNNCFESKNQGHCRLDQER-CSC 275
            ::     |||||||...       .|.||..::||||:|..|..|| .|.:.|:|.|..|: |.|
  Rat   212 NN-----CSGHGKCTTSVSVASQVYCECDKYWKGEACDIPYCKANC-GSPDHGYCDLTGEKLCVC 270

  Fly   276 YEGFAGDDCS--QISAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVGGE--SYGRGKLMSTY 336
            .:.:.|.|||  ..|....|...:.|......|.|||.|.:....:.::||.  :|...:::..|
  Rat   271 NDSWQGPDCSLNVPSTESYWILPNVKPFSPSVGRASHKAVLHGKFMWVIGGYTFNYSSFQMVLNY 335

  Fly   337 DFNGNVWETVHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVK--GHGISNELWAFDVSARTWANI 399
            :...::|.......|   |.:|||.|..:|.:.||||||.::  ...:::|||.|:|.:::|:. 
  Rat   336 NLESSIWNVGAVSRG---PLQRYGHSLALYQENIFMYGGRMETSDGNVTDELWVFNVRSQSWST- 396

  Fly   400 SVRADPSCNATGGTTAMCGPLHVVGHTATLVP-GYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNF 463
               ..|:....|...|      |.||:|.::. ..||    ..|:||||:|..|||.:::||::.
  Rat   397 ---KTPTILGHGQQYA------VEGHSAHIMELDSGD----VVMIVIFGYSAIYGYTSSIQEYHI 448

  Fly   464 ASREWRIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLL 528
            :|..|.:..|.|.:|:|||||::.||.:|:.|||:||..:...:...|...||.||..:|.|::|
  Rat   449 SSNTWLVPETKGAIVQGGYGHTSVYDEMTKSVYVHGGYKALPGNKYGLVDDLYKYEVNSRTWTIL 513

  Fly   529 SAAPSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQA 593
            ..:..||.||:|..:: |.::|||||||||||.|.||||:|.|.|.||:.||.|...|.| :|..
  Rat   514 KESGFARYLHSAVLIS-GAVLVFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKTLPKP-NLHR 576

  Fly   594 DLARFGHSSVVFEESLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCIWDVQKMRC 658
            |:.|||||:||...|:||:|||:..||||:|.|:|..|..:..:|.|..|.||:||:|:  |..|
  Rat   577 DVNRFGHSAVVINGSMYIFGGFSSVLLNDILVYKPPSCKAFRDEELCRNAGPGIKCVWN--KNHC 639

  Fly   659 IAITQVQRSAIYGREQYDYVACPSKSRLTLTSELLHDVHRCQELASCQSCVSTAFGCTYCGNGVC 723
                   .|...|........||.:   |..|:     .||...|.|.||.:...||.:|.:   
  Rat   640 -------ESWESGNANLLRAKCPPR---TAASD-----DRCYRYADCASCTANTNGCQWCDD--- 686

  Fly   724 SKERCRETTSMASVFFESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLA 788
              ::|...:|..|.                 :.::...|.|..|    .:|::|.:|::||.||.
  Rat   687 --KKCISASSNCST-----------------SVRNYTKCHIRNE----QICNKLTSCKSCSLNLN 728

  Fly   789 CRWDSEHNRCKS----------------------------------YTSYGGLALNRTQDEVA-- 817
            |:||.....|::                                  |...|.||...|..||.  
  Rat   729 CQWDQRQQECQALPAHLCGEGWNHVGDSCLRINSSRESYDSAKLYCYNLSGNLASLTTSKEVGFV 793

  Fly   818 ----------------------------------------------------------------- 817
                                                                             
  Rat   794 LDEIQKNTQQRVSPWVGLRKINISYWGWEDMSPFTNTSLQWLPGEPNDSGFCAYLERAAVAGLKA 858

  Fly   818 -------------------------CSPSCASLTNCQNCTED--ECIWCQNEQRCVDRNAYTASF 855
                                     |...|:..|:|.|||.:  ||:||.:.:||||.|||..||
  Rat   859 NPCTSMADGLVCEKPVVSPNQNARPCKKPCSLRTSCANCTSNGMECMWCSSTKRCVDSNAYIISF 923

  Fly   856 PYGQCREWTTFTAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLG 920
            |||||.||.|.|.                    |...|....:|..||:.|.||||::.||||.|
  Rat   924 PYGQCLEWQTATC--------------------SPQNCSGLRTCGQCLEQPGCGWCNDPSNTGRG 968

  Fly   921 RCVVGGA-----LAPYDDTECALK----------HWFFTSCPRCNCNGHSYCNDQQHCEQPCNNL 970
            .|:.|.:     ||...::|.||.          .|.|..||.|.|||||.|.:...||| |.||
  Rat   969 YCIEGSSRGPMKLAGVHNSEVALDTSLCPKEKNYEWSFIQCPACQCNGHSTCINNNVCEQ-CKNL 1032

  Fly   971 TTGAHCEKCRTGYWGNPINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEKCDSQNHYHG 1035
            |||..|:.|..||:|:|.|||:|..|.|.|....||..|||||||||||.||.|:.|||:|.|.|
  Rat  1033 TTGRQCQDCMPGYYGDPTNGGQCTACTCGGHANVCHLHTGKCFCTTKGIKGDQCQLCDSENRYVG 1097

  Fly  1036 DPLKGSCYYELTIDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAKMDI--SVKR 1098
            :||:|:|||.|.|||||||:|.:::|||.|.|||..:|.:...:.|.:|..|....::|  ||..
  Rat  1098 NPLRGTCYYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDISINASNNFNLNITWSVGS 1162

  Fly  1099 AG----SPDMLILVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQY 1159
            .|    ..:..|:..:|...:|..|....:.|..:|:     .||||:|.:|..||.|||||||:
  Rat  1163 TGGTISGEETPIVSKMNIKEYRDSFSYEKFNFRSNPN-----ITFYVYVSNFSWPIKIQIAFSQH 1222

  Fly  1160 PK-LNLQQFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIE-N 1222
            .. ::|.|||:||.||||.|||:|||:|||||.....|||::|..|.:|||||||:.|.|.:| .
  Rat  1223 NTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVG 1287

  Fly  1223 RESID-LSLTLEGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAGLA 1286
            .|..| |...|||           .|.|||:|||:|||||||::.:.||.|.....|.||| |||
  Rat  1288 AEQTDFLRGPLEG-----------APKPIAIEPCAGNRAAVLTVFLCLPRGTSGAPPPGQS-GLA 1340

  Fly  1287 VASALVTLGNPRRPSIDQHPKEPKSK 1312
            :||||:.:.       .|.|.:.|.|
  Rat  1341 IASALIDIS-------QQKPSDNKDK 1359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsdNP_651571.3 CUB 86..212 CDD:238001 59/128 (46%)
NanM <288..391 CDD:442289 30/106 (28%)
KELCH repeat 308..349 CDD:276965 9/42 (21%)
NanM 343..614 CDD:442289 110/273 (40%)
KELCH repeat 358..420 CDD:276965 20/63 (32%)
KELCH repeat 424..474 CDD:276965 18/50 (36%)
KELCH repeat 482..531 CDD:276965 19/48 (40%)
KELCH repeat 535..588 CDD:276965 30/52 (58%)
PSI 821..870 CDD:396154 28/50 (56%)
EGF_Lam 948..994 CDD:238012 25/45 (56%)
EGF_Lam 995..1040 CDD:238012 27/44 (61%)
Atrnl1NP_001418043.1 CUB 92..207 CDD:238001 60/130 (46%)
DSL 234..280 CDD:473190 19/46 (41%)
NanM 302..597 CDD:442289 119/313 (38%)
KELCH repeat 304..352 CDD:276965 10/50 (20%)
KELCH repeat 354..407 CDD:276965 19/56 (34%)
KELCH repeat 520..573 CDD:276965 31/54 (57%)
CLECT 746..872 CDD:470576 7/125 (6%)
PSI 887..936 CDD:396154 27/48 (56%)
EGF_Lam 1011..1056 CDD:238012 25/45 (56%)

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