DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dsd and ATRNL1

DIOPT Version :10

Sequence 1:NP_651571.3 Gene:dsd / 43315 FlyBaseID:FBgn0039528 Length:1323 Species:Drosophila melanogaster
Sequence 2:NP_997186.1 Gene:ATRNL1 / 26033 HGNCID:29063 Length:1379 Species:Homo sapiens


Alignment Length:1455 Identity:515/1455 - (35%)
Similarity:720/1455 - (49%) Gaps:294/1455 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 CFSGLHRAAAFNCTAHGGRCQNDGQCQE----DGQCLCADGWQGPECQFCGGKVRMYHPMGTIHD 101
            |:..|: .|.:...:....|:..|.|..    :..|||..||.|.:||.|.|:.::..|.|.:.|
Human    45 CYGFLY-LALYAQVSQSKPCERTGSCFSGRCVNSTCLCDPGWVGDQCQHCQGRFKLTEPSGYLTD 108

  Fly   102 GWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIYDGDSVDSPLL 166
            |..||....||:|||:. :|:            |.:|:....|||||.|||:|:|||||:.:||:
Human   109 GPINYKYKTKCTWLIEG-YPN------------AVLRLRFNHFATECSWDHMYVYDGDSIYAPLI 160

  Fly   167 AVFSGLM---YRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCPSDSDEVECSG 228
            ||.|||:   .|||   ..||:|:.|||.||:|||||.|||::|||:.|.:||||::     |||
Human   161 AVLSGLIVPEIRGN---ETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINSCPNN-----CSG 217

  Fly   229 HGKCRDG-------DCICDPMYRGEACNIAACPNNCFESKNQGHCRLDQER-CSCYEGFAGDDCS 285
            ||||...       .|.||..::||||:|..|..|| .|.:.|:|.|..|: |.|.:.:.|.|||
Human   218 HGKCTTSVSVPSQVYCECDKYWKGEACDIPYCKANC-GSPDHGYCDLTGEKLCVCNDSWQGPDCS 281

  Fly   286 --QISAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVGGE--SYGRGKLMSTYDFNGNVWETV 346
              ..|....|...:.|......|.|||.|.:....:.::||.  :|...:::..|:...::|...
Human   282 LNVPSTESYWILPNVKPFSPSVGRASHKAVLHGKFMWVIGGYTFNYSSFQMVLNYNLESSIWNVG 346

  Fly   347 HPEDGSEVPDKRYGASTVMYGDKIFMYGGVVKGH--GISNELWAFDVSARTWANISVRADPSCNA 409
            .|..|   |.:|||.|..:|.:.||||||.::.:  .:::|||.|::.:::|:.    ..|:...
Human   347 TPSRG---PLQRYGHSLALYQENIFMYGGRIETNDGNVTDELWVFNIHSQSWST----KTPTVLG 404

  Fly   410 TGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFASREWRIVPTT 474
            .|...|      |.||:|.::.  .|..:. .|::|||:|..|||.:::||::.:|..|.:..|.
Human   405 HGQQYA------VEGHSAHIME--LDSRDV-VMIIIFGYSAIYGYTSSIQEYHISSNTWLVPETK 460

  Fly   475 GYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLSAAPSARLLHT 539
            |.:|:|||||::.||.:|:.:||:||..:...:...|...||.||..|:.|::|..:..||.||:
Human   461 GAIVQGGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFARYLHS 525

  Fly   540 ANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQADLARFGHSSVV 604
            |..:| |.|::||||||||||.|.||||:|.|.|.||:.||.|...|.| :|..|:.|||||:||
Human   526 AVLIN-GAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKP-NLHRDVNRFGHSAVV 588

  Fly   605 FEESLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCIWDVQKMRCIAITQVQRSAI 669
            ...|:||:|||:..||||:|.|:|..|..:..:|.|..|.||:||:|:  |..|.:......:.|
Human   589 INGSMYIFGGFSSVLLNDILVYKPPNCKAFRDEELCKNAGPGIKCVWN--KNHCESWESGNTNNI 651

  Fly   670 YGREQYDYVACPSKSRLTLTSELLHDVHRCQELASCQSCVSTAFGCTYCGNGVCSKERCRETTSM 734
            ...:      ||.|   |..|:     .||...|.|.||.:...||.:|.:     ::|....|.
Human   652 LRAK------CPPK---TAASD-----DRCYRYADCASCTANTNGCQWCDD-----KKCISANSN 697

  Fly   735 ASVFFESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLACRWDSEHNRCK 799
            .|                 ::.|:...|.:..|    .:|::|.:|::||.||.|:||.....|:
Human   698 CS-----------------MSVKNYTKCHVRNE----QICNKLTSCKSCSLNLNCQWDQRQQECQ 741

  Fly   800 S----------------------------------YTSYGGLALNRTQDEV-------------- 816
            :                                  |...|.||...|..||              
Human   742 ALPAHLCGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTQQK 806

  Fly   817 ----------------------------------------------------------------- 816
                                                                             
Human   807 VSPWVGLRKINISYWGWEDMSPFTNTTLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMANGLV 871

  Fly   817 -------------ACSPSCASLTNCQNCTED--ECIWCQNEQRCVDRNAYTASFPYGQCREWTTF 866
                         .|...|:..|:|.|||.:  ||:||.:.:||||.|||..|||||||.||.|.
Human   872 CEKPVVSPNQNARPCKKPCSLRTSCSNCTSNGMECMWCSSTKRCVDSNAYIISFPYGQCLEWQTA 936

  Fly   867 TAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGRCVVGGALAPY 931
            |.                    |...|....:|..||:.|.||||::.||||.|.|:.|.:..|.
Human   937 TC--------------------SPQNCSGLRTCGQCLEQPGCGWCNDPSNTGRGHCIEGSSRGPM 981

  Fly   932 D-----------DTECALK----HWFFTSCPRCNCNGHSYCNDQQHCEQPCNNLTTGAHCEKCRT 981
            .           ||....|    .|.|..||.|.|||||.|.:...||| |.|||||..|:.|..
Human   982 KLIGMHHSEMVLDTNLCPKEKNYEWSFIQCPACQCNGHSTCINNNVCEQ-CKNLTTGKQCQDCMP 1045

  Fly   982 GYWGNPINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEKCDSQNHYHGDPLKGSCYYEL 1046
            ||:|:|.|||:|..|.|:|....||..|||||||||||.||.|:.|||:|.|.|:||:|:|||.|
Human  1046 GYYGDPTNGGQCTACTCSGHANICHLHTGKCFCTTKGIKGDQCQLCDSENRYVGNPLRGTCYYSL 1110

  Fly  1047 TIDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAKMDI--SV-KRAGS---PDML 1105
            .|||||||:|.:::|||.|.|||..:|.:...:.|.:|..|....::|  || ..||:   .:..
Human  1111 LIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDISINASNNFNLNITWSVGSTAGTISGEETS 1175

  Fly  1106 ILVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQYPK-LNLQQFFI 1169
            |:...|...:|..|....:.|..:|:     .||||:|.:|..||.|||||||:.. ::|.|||:
Human  1176 IVSKNNIKEYRDSFSYEKFNFRSNPN-----ITFYVYVSNFSWPIKIQIAFSQHNTIMDLVQFFV 1235

  Fly  1170 TFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIE-NRESID-LSLTL 1232
            ||.||||.|||:|||:|||||.....|||::|..|.:|||||||:.|.|.:| ..|..: |...|
Human  1236 TFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVGAEQTEFLRGPL 1300

  Fly  1233 EGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAGLAVASALVTLGNP 1297
            ||           .|.|||:|||:|||||||::.:.||.|.....|.||| |||:||||:.:...
Human  1301 EG-----------APKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQS-GLAIASALIDISQQ 1353

  Fly  1298 RRPSIDQHPKEPKSKRKQSQHPDSC 1322
            :...........::::..|....:|
Human  1354 KASDSKDKTSGVRNRKHLSTRQGTC 1378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsdNP_651571.3 CUB 86..212 CDD:238001 59/128 (46%)
NanM <288..391 CDD:442289 31/106 (29%)
KELCH repeat 308..349 CDD:276965 9/42 (21%)
NanM 343..614 CDD:442289 108/272 (40%)
KELCH repeat 358..420 CDD:276965 19/63 (30%)
KELCH repeat 424..474 CDD:276965 16/49 (33%)
KELCH repeat 482..531 CDD:276965 18/48 (38%)
KELCH repeat 535..588 CDD:276965 31/52 (60%)
PSI 821..870 CDD:396154 28/50 (56%)
EGF_Lam 948..994 CDD:238012 25/45 (56%)
EGF_Lam 995..1040 CDD:238012 27/44 (61%)
ATRNL1NP_997186.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
CUB 93..208 CDD:238001 60/130 (46%)
DSL 235..281 CDD:473190 19/46 (41%)
NanM 303..598 CDD:442289 117/312 (38%)
KELCH repeat 305..349 CDD:276965 9/43 (21%)
Kelch 1 316..365 13/51 (25%)
KELCH repeat 355..408 CDD:276965 18/56 (32%)
Kelch 2 367..415 16/57 (28%)
Kelch 3 427..475 20/47 (43%)
Kelch 4 480..531 18/51 (35%)
KELCH repeat 521..574 CDD:276965 32/54 (59%)
Kelch 5 533..591 35/58 (60%)
Kelch 6 592..638 22/47 (47%)
CLECT_attractin_like 748..874 CDD:153067 7/125 (6%)
PSI 889..938 CDD:396154 27/48 (56%)
EGF_Lam 1013..1058 CDD:238012 25/45 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1354..1379 2/25 (8%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.