DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsd and atrn-1

DIOPT Version :9

Sequence 1:	NP_001263013.1	Gene:	dsd / 43315	FlyBaseID:	FBgn0039528	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_510443.5	Gene:	atrn-1 / 181566	WormBaseID:	WBGene00006432	Length:	1269	Species:	Caenorhabditis elegans

Alignment Length:	1386	Identity:	445/1386 - (32%)
Similarity:	656/1386 - (47%)	Gaps:	241/1386 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CLLLLTLLLFHGCFSGLH----------RAAAFNC--TAHGGRCQNDGQCQEDGQCLCADGWQGP 81
            |.:....|||. .||.:|          ..:..:|  ..:.|.|.|..       |:|:.||.|.
Worm    10 CFIFRVFLLFQ-VFSRVHTLTNHANFEFEKSLSSCDKPCYNGVCLNKA-------CVCSKGWYGS 66

  Fly    82 ECQFCGGKVRMYHPMGTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTAN-IRIHLREFA 145
            :|..|.|::|:......|.||..:||.|.||:|||:             |..:|. ::|.:..|.
Worm    67 QCDHCFGRIRISDNASYISDGPLDYSPSAKCTWLIE-------------PENSATPLKIRINSFF 118

  Fly   146 TECGWDHLYIYDGDSVDSPLLAVFSGLMYRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNL 210
            ||||||:|||||||||....||...|......|:        |.||.||||||||.|.|::|||:
Worm   119 TECGWDYLYIYDGDSVYGKQLAALCGEQPSQEFT--------AASGKALVHFFSDLAINLNGFNV 175

  Fly   211 TYKMNSCPSDSDEVECSGHGKCRDGDCICDPMYRGEACNIAAC--PNNCFESK-NQGHCRLDQER 272
            :|:.|.|     ...||.||.|.:|.|.|:..|:|..|....|  .....||. ::|.| :| .|
Worm   176 SYESNRC-----AYNCSNHGSCLNGKCDCEDGYKGLNCEYQVCQLSGKSTESPCHEGQC-VD-GR 233

  Fly   273 CSCYEG-FAGDDCSQISAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVGGESYGRG---KLM 333
            |.|... ..|:.|....:...|..:||.:: ||.|.|||.:....|.:..:|||.:...   ..:
Worm   234 CECLSARVHGETCQMPVSSSVWDLIHPTNN-APTGKASHASIAIDDVVWSIGGEFFDGSSDPNNI 297

  Fly   334 STYDFNGNVWETVHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVK-------GHGISNELWAFDV 391
            ..|:....:|..|  |...::|..|:..:.|.|.:|::|:|||.|       ....:||||.||:
Worm   298 DVYNVTSRIWSKV--EVSGDMPKPRFDHTVVKYKNKLYMFGGVTKTQVRHQTTQAATNELWIFDM 360

  Fly   392 SARTWANISVRADPSCNATGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLN 456
            .::.||.         ......|.:..|..|.||:|.::        ...|.||||::|.:|:::
Worm   361 GSKKWAQ---------QIHKNETIIAAPFAVAGHSAHVI--------RSEMFVIFGYNPLFGFMH 408

  Fly   457 TVQEFNFASREWRIVPTTGYVVKGGYGHSAAYDFLT----EKVYVYGGIVSESESSQVLSSRLYA 517
            .||.:||.:.||.:..|:.:|. |.:.|||. ::.|    ..:.||||    |..:..::..|..
Worm   409 HVQIYNFETEEWTVANTSDHVY-GRFKHSAV-EYTTPTGATAILVYGG----SMWNNTITDSLMQ 467

  Fly   518 YEPATRVWSLLSAAPSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSW 582
            ::.:|:.||.|..:.....||.|.::| |||:|.||...|.|:.| .::|:|..:..|||.|..|
Worm   468 FDTSTKKWSNLPQSGVQLYLHAAAYLN-GLMVVVGGRGSNVTAGS-KSECFSNMVQSYDVACKQW 530

  Fly   583 -HYHPMPGHLQADLARFGHSSVVFEESLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPG 646
             :....|    .||.|||||..|..:.||..|||||::.:|:....|..||..|:.::|.....|
Worm   531 SNMSTAP----VDLKRFGHSVHVIGQKLYALGGFNGKMKSDVWTLSPAKCSSATRPDECRLITDG 591

  Fly   647 VKCIWDVQKMRCIAITQVQ------RSAIYGREQYDYVACPSKS-RLTLTSELLHDVHRCQELAS 704
            .||::  ....|:......      .|.|.......:..|.:.. ||.|.:        |:|...
Worm   592 TKCVF--VDSSCVPFDPTVSYKSSFASMIKSSTPKSFDECTNTPLRLALKT--------CEEQTD 646

  Fly   705 CQSCVSTAFGCTYCGNG---VCSKERCRETTSMASVFFESSTQMAVSTASPPLNAKHLDSCPISE 766
            |.||.|.: ||.:|.:|   :.:::.|.:...|.:.:.:...:.:|:|..|
Worm   647 CVSCASKS-GCGWCSSGEQCLPNEQECVDGPGMLTSWEKCPQRNSVATMRP-------------- 696

  Fly   767 EYLVSSVCDQLHNCRACSANLACRWD---------------------------SEHNRCKSYTSY 804
                   |:..:||.:|..:..|.|.                           ::.|:..|.:.:
Worm   697 -------CNMENNCGSCRISPHCTWYPIDKASPCVSKEDLIAVVYEYETKSVLADRNKFLSPSHF 754

  Fly   805 GGLALNRTQDEVACSPSCASLTNCQNCTE-DECIWCQNEQRCVDRNAYTASFPYGQCREWTTFTA 868
            .....|.|:    |...||...||.:||: ::|:||.:..||::..|||.||.||||..|.|
Worm   755 PSFFRNATE----CPMPCAQRNNCSDCTDLEQCMWCPSTNRCINLEAYTLSFAYGQCHSWVT--- 812

  Fly   869 KCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGRCVVG---GALAP 930
                   ..:...:.......|..|..:.:|..|..||.|||..:.|.||||.|:.|   |.|.|
Worm   813 -------SGSGSVINRVCQAESVVCEEHKTCGECQRDPGCGWLADDSKTGLGLCIRGTSTGPLEP 870

  Fly   931 YDDTECALKHWFFTSCPRCNCNGHSYCNDQ---------QHCEQPCNNLTTGAHCEKCRTGYWGN 986
            ..:...    |:|..||.|.|||||.|...         :.| |.|.|.|||||||:|..|::|:
Worm   871 KPENST----WYFIDCPACQCNGHSTCFTSVGSFPPVTIEKC-QSCQNHTTGAHCERCAPGFYGD 930

  Fly   987 PINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEKCDSQNHYHGDPLKGS-CYYELTIDY 1050
            ..|||.|..|||:.|...|.|.:|:|||.|||:.||.|:||:::  |.|:|..|: |:|||.:|:
Worm   931 ARNGGVCSPCDCHHQADMCDPVSGQCFCKTKGVTGDRCDKCEAK--YVGNPRNGTPCFYELAVDF 993

  Fly  1051 QFTFNL-SKKEDRHFTQINFRNSPGKPEIDADFTITCSVP-------AKMDIS-VKRAGSPDMLI 1106
            .|||.| |..:|.|.::|...:.|.|.:.|..|.|:|..|       ..|..| |.........:
Worm   994 IFTFKLRSDDKDNHTSEIYLYSVPYKKDTDVTFQISCESPKGNALVALNMTSSYVNGLADKSQAM 1058

  Fly  1107 LVGVNCST--FRHRFPKTD--YQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQYPKLNLQQF 1167
            :|...|.:  ||..:..:|  |.||  ||.|   |||:|.|::|..|:.|.::|:|.|.:|...|
Worm  1059 MVDTICDSKGFRRVYVASDKGYPFG--PDSN---TTFFVRVYNFNTPVQIVVSFAQSPPINWVLF 1118

  Fly  1168 FITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIENRESIDLSLTL 1232
            |:.|::||::||::|.:||.||.:.:.:||.||...|:|.||||||:..        .::||:
Worm  1119 FVIFAACFIVLLVVAGLLWMIKVRIEAYRRNQRRIDEIEHMASRPFAST--------KMELSM-- 1173

  Fly  1233 EGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAGLAVASALVTLGNP 1297
                 ||:......|:|:::||||..||.|.:|.|||||||.:..|||.| ||||||:|..| .|
Worm  1174 -----LSQFSSAGGPTPLSIEPCSNYRAGVFTLAVRLPTGGKAVTPSGTS-GLAVASSLCLL-TP 1231

  Fly  1298 RRPSI--DQHPKEPKSKRKQS 1316
            ::..:  .|...|..|.||.:
Worm  1232 QQVGVLQAQDNGESNSGRKSN 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_001263013.1	CUB	86..212	CDD:238001	53/126 (42%)
		PLN02153	290..582	CDD:177814	90/305 (30%)
		KELCH repeat	308..349	CDD:276965	10/43 (23%)
		Kelch_5	355..391	CDD:290565	15/42 (36%)
		KELCH repeat	358..420	CDD:276965	18/68 (26%)
		KELCH repeat	424..474	CDD:276965	16/49 (33%)
		KELCH repeat	482..531	CDD:276965	14/52 (27%)
		KELCH repeat	535..588	CDD:276965	20/53 (38%)
		PSI	821..870	CDD:279745	22/49 (45%)
		EGF_Lam	948..994	CDD:238012	24/54 (44%)
		EGF_Lam	995..1040	CDD:238012	21/44 (48%)
atrn-1	NP_510443.5	CUB	71..179	CDD:238001	54/128 (42%)
		Kelch_4	269..317	CDD:315981	11/49 (22%)
		KELCH repeat	269..316	CDD:276965	11/48 (23%)
		PLN02193	307..>559	CDD:330882	88/282 (31%)
		KELCH repeat	320..379	CDD:276965	18/67 (27%)
		KELCH repeat	382..422	CDD:276965	17/47 (36%)
		KELCH repeat	485..537	CDD:276965	20/53 (38%)
		PSI	640..686	CDD:307546	12/54 (22%)
		PSI	767..816	CDD:307546	22/58 (38%)
		EGF_Lam	884..937	CDD:238012	24/53 (45%)
		EGF_Lam	939..985	CDD:238012	22/47 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166271
Domainoid	1	1.000	87	1.000	Domainoid score	I5107
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22542
Inparanoid	1	1.050	651	1.000	Inparanoid score	I421
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49386
OrthoDB	1	1.010	-	-		D32816at33208
OrthoFinder	1	1.000	-	-		FOG0003093
OrthoInspector	1	1.000	-	-		oto19792
orthoMCL	1	0.900	-	-		OOG6_105013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2833
SonicParanoid	1	1.000	-	-		X2068
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.840