Protein Alignment dsd and Megf8

DIOPT Version :10

• Sequence 1: NP_651571.3
• Gene: dsd / 43315
• FlyBaseID: FBgn0039528
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: XP_061518481.1
• Gene: Megf8 / 1277785
• VectorBaseID: AGAMI1_013311
• Length: 3104
• Species: Anopheles gambiae
• Alignment Length: 1767
• Identity: 412/1767 - (23%)
• Similarity: 600/1767 - (33%)
• Gaps: 651/1767 - (36%)

  Fly    52 NCTAHG----GRCQNDGQCQEDGQCLCADGWQGPECQFC----------GGKVRMYH-------- 94
            :|..||    |.|.     .:.|:|.|.|..:|..|:.|          ||  :.||
Mosquito  1414 DCNGHGNVALGICD-----AKTGECYCQDYTEGLRCEMCNRNFYGDPKDGG--QCYHQCASRGVL 1471

  Fly    95 -PMGTIHDGWGNYSVSVKCSWL-IDARHPHWNRRHNTNPS-----------------------RT 134
             .:||  .|.|::. |.:.||. .:.|...|    ..:|.                       |.
Mosquito  1472 TQVGT--QGLGSFQ-SYRSSWSGQETRECLW----IVSPQGRGGGGGAAAGGAGGTSALSTELRN 1529

  Fly   135 ANIRIHL--REFATECGWDHLYIYD------GDSVDSPLLAVFSGLMYRGNFSIRRVPQVIATSG 191
            |.|:|.:  ......||.:.:|:||      |.:....|:|||.. ..||::...      |.||
Mosquito  1530 AIIQIEIEPERMNVTCGENAVYVYDGLPDLTGVAQQKQLIAVFCS-EDRGSWIAE------ARSG 1587

  Fly   192 TALVHFFSDDAYNMSGFNLTYKMNSCPSDSDEVECSGHGKCR-DGDCICDPMYRGEACNIAACPN 255
            ...|||....:.. .|||..|.:.||.:.|    |.....|. ||.|:|...:.|..|.:..||:
Mosquito  1588 HLTVHFKKGPSPE-QGFNAIYSVLSCAAAS----CQRPYLCSDDGRCVCPKGFTGPRCMMRICPS 1647

  Fly   256 NCFESKNQGHCRLDQERCSCYEGFAGDDCSQISAHGAWSTVHPK--------HSPAPAGSASH-- 310
            :|.|...:|.|.....||.|..|:.|||||        ..|.|.        :|...:.|..|
Mosquito  1648 DCNEESKRGTCDNGYGRCICAPGYGGDDCS--------LAVRPSSVVFTELFNSYLVSDSFEHLR 1704

  Fly   311 ------GATIWRD---TLHIVGGESYGRGKL--MSTYDFNGNVWETV----HPEDGSEVPDKRYG 360
                  |.::..|   :|.:.||.|...|.|  :..:|...|.|..|    .|||  .:|..||.
Mosquito  1705 KTLPRFGHSLVADRRGSLWMFGGYSLSHGPLNDIRQFDTKNNTWMQVTVDSSPED--RMPQGRYY 1767

  Fly   361 ASTVMYGDK--IFMYGGVVKGHGISNELWAFDVSARTWANISVRADPSCNATGGTTAMCGPLHVV 423
            .:..:.|.:  |::|||:.: :|..::||.|.:..:.|:.:..:     |||       .|..:.
Mosquito  1768 HAADIIGSRQAIYVYGGLSR-NGTLDDLWQFALQTQRWSLVVPQ-----NAT-------RPPALA 1819

  Fly   424 GHTATLVPGYGDKNNYQYMVVIFGHSPNY---GYLNTVQEFNFASREWRIVPTTGYVVKGGYGHS 485
            |||.|.|      ...:.:::|.|:|.:.   |..::|..||.|:..|.||.|.|...:|.|||:
Mosquito  1820 GHTLTAV------GREELLLLIGGYSISERGGGLQSSVWLFNVATGTWSIVTTHGSSPRGIYGHT 1878

  Fly   486 AAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLSA--------APSARLLHTANF 542
            |.|...:..||||||:......:..:|.||||:...||.|:.|.:        .|.||.||:| .
Mosquito  1879 AVYHAQSSAVYVYGGVRIGDSGNLAVSKRLYAFSIPTRRWTELPSFIHHGPDYVPPARYLHSA-V 1942

  Fly   543 VNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVY-CDSWHYHPMPGHLQADLAR----FGH-- 600
            ..:..|:||||....:.:.|..    .::::|..|| |:.|.      .|..|..:    :||
Mosquito  1943 ATEHYMLVFGGRVAGNGTVSLA----REEVMVAYVYRCNQWI------RLAKDAEKVGGSYGHTY 1997

  Fly   601 SSVVFEE----SLYIYGGFNG---------QLLNDMLRYQPG---YCSYYTKQEKCTA----ARP 645
            :..:.::    |:|:..|::|         .|..||.....|   :|..|:....|:.    ..|
Mosquito  1998 AQAMAQDPDGGSIYVVAGWDGSNHCRVTRIDLPADMCELWSGSKYFCRQYSGCSFCSVKGMPGEP 2062

  Fly   646 GVKCIWDVQKMRCIAITQVQRSAIYGREQY----DYVACPS-------KSRLTLTSELLHDVHRC 699
            ...|                         |    .|.||..       .|..:..||.: ....|
Mosquito  2063 ASHC-------------------------YSAGGSYHACEGYNGTISFNSGTSCDSEWI-GRRTC 2101

  Fly   700 QELASCQSCVST-------------------AFGC----TYCG--NGV----------------- 722
            ....:|.||::|                   .|.|    ..||  ||.
Mosquito  2102 ASFITCSSCLATYPWHGEQESPCKWCPDCHPTFSCVDRTADCGMYNGCIANQTAILQDECPVGTA 2166

  Fly   723 ----CSKERCRETTSMASVFFESSTQMAVST---------ASPPLNAKHLDSCPISEEYLVSSVC 774
                |..:.|....:::...:|...|...:.         .:.|.|...::.||:.        |
Mosquito  2167 GGRSCLADDCEACLALSGCSWEREEQGGAAARYRCQERQDETEPRNDTKVERCPLP--------C 2223

  Fly   775 DQLHNCRAC----SANLACRWDSEHNRCKS------YTSYG--GLALNRTQDEVACSPSCASLTN 827
            :...||..|    |.:..|.|.::.|.|.|      |.|.|  ||.:: ..|...|...|||.|.
Mosquito  2224 NAFRNCSTCVKHDSRSSECLWSTQLNECISQTFQPLYCSGGICGLVVS-PNDPQHCPEPCASFTQ 2287

  Fly   828 CQNCTEDE-CIWCQNEQRCVDRNAYTASFPYGQCREWTT-------FTAKCRSAPIQSTALAVGS 884
            |.:|.... |.||       .||.....   |.|.|.:.       ..|.| :|..|:.:.|..:
Mosquito  2288 CSSCLRHAYCGWC-------SRNGTDGD---GVCTEGSVDGPANHPAGATC-AAIYQTRSKAPAN 2341

  Fly   885 TT---ALSSAQCGYYNSC-----------QMCLD-----DPACGWCDNGSNTGLGRCVVGGALAP 930
            ||   ..:..:|...|.|           |.|:|     :..|....|.|:...|....||...|
Mosquito  2342 TTEPFGWNYFKCPPENECANGHHNCNAKSQRCVDHLHGYECVCAPGYNSSSLAGGGGGSGGVCVP 2406

  Fly   931 ----------------------YDDTECALKHWFFTSCPRCNCNGHSYCN--DQ-QHCEQPCNNL 970
                                  |....|::         :|.|||||.|:  || ..|.| |:|.
Mosquito  2407 VCSQGCVRGTCTEPDVCRCDFGYVGANCSI---------QCQCNGHSNCSGADQLDRCGQ-CHNN 2461

  Fly   971 TTGAHCEKCRTGYWGNPINGG-------------------------------------------- 991
            |.||.|:||...|.|:|.|||
Mosquito  2462 TMGAQCDKCLPFYVGDPRNGGTCVPCVQYCNGQTDLCIAREQEATMRNMSRQELKRLVTEGPMTD 2526

  Fly   992 -------------------------------KCQRCDCNGQGVYCHPDTG-KC----------FC 1014
                                           .|..|:|||.|..|.|.|| ||          .|
Mosquito  2527 AICLGCGNYTDGDQCETCVPGYFRKSATPGKACSPCECNGHGDMCDPMTGEKCNCGNNTESDNTC 2591

  Fly  1015 TTKGIVGDH--------CEKCDSQNHYHGDPLKG-SCYYELTIDYQFTFNLSKKEDRHFTQINFR 1070
            ::||  .:|        |.||  ::.|.|.|..| .||..:|::.:..|: :|..|    :...:
Mosquito  2592 SSKG--KNHAFNCWSLQCTKC--RDSYSGHPNNGHQCYKHITVESRMCFD-AKTID----ECKIK 2647

  Fly  1071 NSPGKPEIDADFTITCSVPAKMDISVK-----RAG------SP-DMLILVGVNCSTFRH------ 1117
            ..|.||.....|.|.   |..|::.::     ..|      || |...:|..|.||..|
Mosquito  2648 PQPLKPGQTVFFVIQ---PRYMNVDIRFIVDVTQGELDFYMSPTDESFIVHTNTSTGDHDILLDS 2709

  Fly  1118 ---RFPK-----------------------TDYQFGHSP--DDNSS------------------- 1135
               .||:                       .:.::...|  .|.||
Mosquito  2710 RYVSFPQRVAGPTLWSPLSSSTSQPDEMYPLNIKYSEEPLAGDKSSPVCGGLLNEGFHVTDRTAH 2774

  Fly  1136 -LTTFY----------VF-------------VHDF-QPPIWIQ------------IAFSQYPKLN 1163
             |.|:.          ||             ||.. |...:|.            :.|.:..:|:
Mosquito  2775 DLITYVTLRQCKSILRVFGLKNRLVVTLPHTVHALGQTKFYIALRARPGSTASYGLVFFRQDQLH 2839

  Fly  1164 LQ--QFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIENRESI 1226
            :.  .||..|.|||.|.|.:..:.||.||..||.|.|:|..|||..||.|||.:|        ::
Mosquito  2840 IHLFVFFSVFFSCFFLFLAICVLAWKAKQAADMRRARRRQVVEMLHMAKRPFGRV--------NL 2896

  Fly  1227 DLSLTLEGIG----------------------------------------------HLSKKRKKE 1245
            .|....||.|                                              |..:.:.::
Mosquito  2897 SLECPSEGGGTTPAPQRRRGRSSKHSTGGSAGSSATVAHAHHHHHHHHHHHHQQQHHQQQHQHQQ 2961

  Fly  1246 CPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAGLAVASALVTLGNPRRPSIDQHPKEPK 1310
            ...||||||.:.|.|||.::.||||  |..:|    ...||:||||:.:|. |..|...:|...:
Mosquito  2962 DVGPIALEPTADNYAAVGTVFVRLP--GKQKA----QITLALASALIVMGG-RSSSGGSYPSHER 3019

  Fly  1311 S------KRKQS 1316
            :      :|:.|
Mosquito  3020 AAGGRHHRRRSS 3031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_651571.3	CUB	86..212	CDD:238001	40/176 (23%)
		NanM	<288..391	CDD:442289	32/129 (25%)
		KELCH repeat	308..349	CDD:276965	13/57 (23%)
		NanM	343..614	CDD:442289	84/298 (28%)
		KELCH repeat	358..420	CDD:276965	15/63 (24%)
		KELCH repeat	424..474	CDD:276965	16/52 (31%)
		KELCH repeat	482..531	CDD:276965	20/56 (36%)
		KELCH repeat	535..588	CDD:276965	15/53 (28%)
		PSI	821..870	CDD:396154	15/56 (27%)
		EGF_Lam	948..994	CDD:238012	25/123 (20%)
		EGF_Lam	995..1040	CDD:238012	21/63 (33%)
Megf8	XP_061518481.1	None