Protein Alignment dsd and dsd

DIOPT Version :10

• Sequence 1: NP_651571.3
• Gene: dsd / 43315
• FlyBaseID: FBgn0039528
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: XP_309653.6
• Gene: dsd / 1270925
• VectorBaseID: AGAMI1_014526
• Length: 1317
• Species: Anopheles gambiae
• Alignment Length: 1351
• Identity: 811/1351 - (60%)
• Similarity: 990/1351 - (73%)
• Gaps: 101/1351 - (7%)

  Fly    23 AKYRRK---------------------CLLLLTLLLFHGCFSGLHRAAAFNCTAHG--------- 57
            :|||||                     ..|.|.:||...|    |.......::||
Mosquito    16 SKYRRKRDPPPIRSMVGGRPASPHSSVWRLALLVLLALSC----HLGPTVLVSSHGLAGVADPGK 76

  Fly    58 ---GRCQNDGQCQEDGQCLCADGWQGPECQFCGGKVRMYHPMGTIHDGWGNYSVSVKCSWLIDAR 119
               .||.|.|.| ::|.|||.|||||.||||||||||:..|.|:||||.||||:.||||||||||
Mosquito    77 CSEVRCMNGGVC-KNGTCLCPDGWQGSECQFCGGKVRLTEPSGSIHDGLGNYSIGVKCSWLIDAR 140

  Fly   120 -HPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIYDGDSVDSPLLAVFSGLMYRGNFSIRRV 183
             |.....:.:|.|.|.:.||:||.||||||||||||:||||||:|||||||||||||.||:|||:
Mosquito   141 EHNSITDKVSTEPGRPSVIRLHLEEFATECGWDHLYVYDGDSVESPLLAVFSGLMYRKNFTIRRI 205

  Fly   184 PQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCPSDSDEVECSGHGKCRDGDCICDPMYRGEAC 248
            |:|.|.||:||:||||||||||||||::|::|:||::...:.|||:|.|.:|:|.|:..:.|.||
Mosquito   206 PEVFAHSGSALLHFFSDDAYNMSGFNISYQVNACPTNDSLLNCSGNGDCWNGECSCNSGFTGAAC 270

  Fly   249 NIAACPNNCFESKNQGHCRLDQERCSCYEGFAGDDCSQISAHGAWSTVHPKHSP--APAGSASHG 311
            |:..|||.|.....:|.|...|:||.|..|:.|:||||..|||.|:.:....:.  .|.||||||
Mosquito   271 NVPRCPNYCSAHLGRGVCDRKQQRCVCSAGYTGNDCSQAIAHGYWTAIDAGETEGFTPPGSASHG 335

  Fly   312 ATIWRDTLHIVGGESYGRGK-LMSTYDFNGNVWETVHPEDGSEVPDKRYGASTVMYGDKIFMYGG 375
            |.::.|||:::.|||||:.: |:..|||||.||||.|.| ....|:.|||||||::|||||||||
Mosquito   336 AAVFHDTLYVIAGESYGKAEALLYMYDFNGKVWETAHTE-SRPAPELRYGASTVIFGDKIFMYGG 399

  Fly   376 VVKGHGISNELWAFDVSARTWANISVRADPSCNATGGTTAMCGPLHVVGHTATLVPGY----GDK 436
            |::|.|:..|||||||||:.|.||:|:|: .||   .|..|||||...|||||:|..|    |.|
Mosquito   400 VIEGRGVCGELWAFDVSAKIWENITVKAE-QCN---DTYEMCGPLRSAGHTATIVSNYDQVGGKK 460

  Fly   437 -----NNYQYMVVIFGHSPNYGYLNTVQEFNFASREWRIVPTTGYVVKGGYGHSAAYDFLTEKVY 496
                 .:.|.|||||||||.:|||||||||||.:||||||||.||.||||||||||||.|.|::|
Mosquito   461 VLTGGGSSQKMVVIFGHSPQFGYLNTVQEFNFGTREWRIVPTRGYPVKGGYGHSAAYDPLRERIY 525

  Fly   497 VYGGIVSESESSQVLSSRLYAYEPATRVWSLLSAAPSARLLHTANFVNQGLMMVFGGNTHNDTSQ 561
            |||||||||:|||:||::||:|||..|:|:||..||:||.||||||:..|||||||||||||||.
Mosquito   526 VYGGIVSESDSSQLLSNKLYSYEPHERLWTLLETAPTARFLHTANFLTPGLMMVFGGNTHNDTSH 590

  Fly   562 SYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQADLARFGHSSVVFEESLYIYGGFNGQLLNDMLRY 626
            |:||||||:||:||||.|||||..|||..|.|||||||||:||||.|||:||||:||::||||::
Mosquito   591 SFGAKCYSRDLMVYDVLCDSWHAQPMPDDLYADLARFGHSAVVFERSLYVYGGFDGQMVNDMLQF 655

  Fly   627 QPGYCSYYTKQEKCTAARPGVKCIWDVQKMRCIAITQVQRSAIYGREQYDYVACPSKSRLTLTSE 691
            .||.|..:.:.::|..|||||||:||:||.||:....|||..::.|:|.....||.||||.:|..
Mosquito   656 TPGDCQAFNRTDQCLNARPGVKCVWDIQKSRCLPAAAVQRERLFDRDQEGLEVCPKKSRLVMTQH 720

  Fly   692 LLHDVHRCQELASCQSCVSTAFGCTYC----GNGVCSKERCRETT-SMASVFFESSTQMAVSTAS 751
            .|.|...|.:|.:||.|||||:||.:|    |.|:|.||:|.:.: :..:.|:.:
Mosquito   721 ELMDYELCSQLTTCQGCVSTAYGCMFCGIGNGKGICVKEKCPDVSYTYRADFYPT---------- 775

  Fly   752 PPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLACRWDSEHNRCKSYTSYGGLALNRTQDEV 816
                 |.|..||.::|:    ||.|||.|.||:|...|.||.||:||:...:..|.|||.
Mosquito   776 -----KALKDCPDNDEH----VCAQLHGCHACTAVSVCHWDYEHSRCQYSRNKSGDALND----- 826

  Fly   817 ACSPSCASLTNCQNCTEDECIWCQNEQRCVDRNAYTASFPYGQCREWTTFTAKCRSAPIQSTALA 881
            ||.|:|:.||:|.|||::|||||||||||||:|||||||||||||||||.::|||:|
Mosquito   827 ACPPACSGLTSCGNCTQEECIWCQNEQRCVDKNAYTASFPYGQCREWTTGSSKCRAA-------- 883

  Fly   882 VGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGRCVVGGALAPYDDTECALKHWFFTSC 946
                 :...:|||:|.:|..|.|||||||||:||.||||:|:.||....::::||..:.|.||.|
Mosquito   884 -----SSGKSQCGFYRTCAQCRDDPACGWCDDGSLTGLGKCLPGGDSGAHEESECPAQRWHFTHC 943

  Fly   947 PRCNCNGHSYCNDQQHCEQPCNNLTTGAHCEKCRTGYWGNPINGGKCQRCDCNGQGVYCHPDTGK 1011
            |.|.|||||.|.|.:.|:|||:|||.|.:|:||:.|:||||:|||.||:|:||||..|||.:|||
Mosquito   944 PSCQCNGHSTCPDAKTCKQPCSNLTFGPNCDKCKPGFWGNPVNGGICQKCECNGQAQYCHSETGK 1008

  Fly  1012 CFCTTKGIVGDHCEKCDSQNHYHGDPLKGSCYYELTIDYQFTFNLSKKEDRHFTQINFRNSPGKP 1076
            |||:|||:.||||||||:.|||||||.:|||||:||||||||||||||||||||||||||||.||
Mosquito  1009 CFCSTKGLAGDHCEKCDATNHYHGDPSRGSCYYDLTIDYQFTFNLSKKEDRHFTQINFRNSPVKP 1073

  Fly  1077 EIDADFTITCSVPAKMDISVKRAGSPDMLILVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYV 1141
            :|||||||||||.|:|:|:::.||..:..:...|||||||:||.|.::|||  .:||.:||||||
Mosquito  1074 DIDADFTITCSVAARMNITIRTAGGIEKPLFSAVNCSTFRYRFSKAEHQFG--VEDNVTLTTFYV 1136

  Fly  1142 FVHDFQPPIWIQIAFSQYPKLNLQQFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEME 1206
            :|:|||||:||||||||||||||||||||||:||||||:|||:||||||.|||||||||||||||
Mosquito  1137 YVYDFQPPLWIQIAFSQYPKLNLQQFFITFSTCFLLLLVMAAILWKIKQHYDMFRRRQRLFVEME 1201

  Fly  1207 QMASRPFSQVLVDIENRESIDLSLTLEGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPT 1271
            ||||||||||||:||:||..:||..:|.|....:||||:.|||||||||.|||||||||||||||
Mosquito  1202 QMASRPFSQVLVEIESREYNELSPAVENITAAPRKRKKDSPSPIALEPCEGNRAAVLSLLVRLPT 1266

  Fly  1272 GGLSQAPSGQSAGLAVASALVTLGNPRRPSIDQHPKEPKSKRKQSQHPDSC 1322
            |||..:|.||||||||||||||||||||.|| :||||||:|||||||||||
Mosquito  1267 GGLQHSPPGQSAGLAVASALVTLGNPRRSSI-EHPKEPKTKRKQSQHPDSC 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_651571.3	CUB	86..212	CDD:238001	91/126 (72%)
		NanM	<288..391	CDD:442289	57/105 (54%)
		KELCH repeat	308..349	CDD:276965	24/41 (59%)
		NanM	343..614	CDD:442289	189/279 (68%)
		KELCH repeat	358..420	CDD:276965	39/61 (64%)
		KELCH repeat	424..474	CDD:276965	37/58 (64%)
		KELCH repeat	482..531	CDD:276965	34/48 (71%)
		KELCH repeat	535..588	CDD:276965	41/52 (79%)
		PSI	821..870	CDD:396154	37/48 (77%)
		EGF_Lam	948..994	CDD:238012	27/45 (60%)
		EGF_Lam	995..1040	CDD:238012	32/44 (73%)
dsd	XP_309653.6	None