DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dsd and Atrn

DIOPT Version :9

Sequence 1:NP_001263013.1 Gene:dsd / 43315 FlyBaseID:FBgn0039528 Length:1323 Species:Drosophila melanogaster
Sequence 2:XP_006498669.1 Gene:Atrn / 11990 MGIID:1341628 Length:1510 Species:Mus musculus


Alignment Length:1478 Identity:513/1478 - (34%)
Similarity:711/1478 - (48%) Gaps:335/1478 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MCL------AAEPPQKQPNRSSTSPTFNAKYRRKCLLLLTLLLF-----------HGCFSGLHRA 48
            :||      |..||...|                  ||.:|||.           ....||...|
Mouse    86 LCLPRVLSRALPPPPLLP------------------LLFSLLLLPLPREAEAAAVAAAVSGSAAA 132

  Fly    49 AAFNC---TAHGGRCQNDGQCQEDGQCLCADGWQGPECQFCGGKVRMYHPMGTIHDGWGNYSVSV 110
            .|..|   ..:|||| |.|    .|||:|..||.|.:||.|||:.|:....|.:.||.|||....
Mouse   133 EAKECDRPCVNGGRC-NPG----TGQCVCPTGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKT 192

  Fly   111 KCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIYDGDSVDSPLLAVFSGLMYR 175
            ||:|||:.:           |:|.  :|:....|||||.|||||:|||||:.:||:|.||||:..
Mouse   193 KCTWLIEGQ-----------PNRI--MRLRFNHFATECSWDHLYVYDGDSIYAPLIAAFSGLIVP 244

  Fly   176 GNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCPSDSDEVECSGHGKCRDG----- 235
            ........|:|..|||.||:|||||.|||::|||:||..:.||::     |||.|:|:..     
Mouse   245 ERDGNETAPEVTVTSGYALLHFFSDAAYNLTGFNITYNFDMCPNN-----CSGRGECKSSNSSSA 304

  Fly   236 -DCICDPMYRGEACNIAACPNNCFESKNQGHCRLDQER-CSCYEGFAGDDCS-QISAHGAWSTVH 297
             :|.|...::||:|:|..|.:|| ...::|.|.....| |||:..:.|..|| .:.|:.::.| .
Mouse   305 VECECSENWKGESCDIPHCTDNC-GFPHRGICNASDTRGCSCFPHWQGPGCSIPVPANQSFWT-R 367

  Fly   298 PKHSPAPAGSASHGATIWRDTLHIVGGESYGRG--KLMSTYDFNGNVWETVHPEDGSEVPDKRYG 360
            .::|......|||.|.:..:.:.:|||..:...  .::..||.....|..::....|.|  .|||
Mouse   368 EEYSDLKLPRASHKAVVNGNIMWVVGGYMFNHSDYSMVLAYDLTSREWLPLNHSVNSVV--VRYG 430

  Fly   361 ASTVMYGDKIFMYGGVVKGHG-ISNELWAFDVSARTWANISVRADPSCNATGGTTAMCGPLHVVG 424
            .|..::.|||:||||.:...| ::|||..|.:...:|..::.:|...             ..|||
Mouse   431 HSLALHKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKDQ-------------YAVVG 482

  Fly   425 HTA---TLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFASREWRIVPTTGYVVKGGYGHSA 486
            |:|   ||..|      ...|:|||||.|.|||::.|||::.....|.|:.|.|.:|:||||||:
Mouse   483 HSAHIVTLASG------RVVMLVIFGHCPLYGYISVVQEYDLEKNTWSILHTQGALVQGGYGHSS 541

  Fly   487 AYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLSAAPSARLLHTANFVNQGLMMVF 551
            .||..|:.:||:||..:.|.:...|:..||.|:..|::|::|..:...|.||||..|: |.|:||
Mouse   542 VYDDRTKALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFFRYLHTAVIVS-GTMLVF 605

  Fly   552 GGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQADLARFGHSSVVFEESLYIYGGFN 616
            |||||||||.|:||||:|.|.:.||:.||.|...|.| .|..|:.|||||:|::..::|::||||
Mouse   606 GGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRP-ELHHDVNRFGHSAVLYNSTMYVFGGFN 669

  Fly   617 GQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCIWDVQKMRCIA---ITQVQRSAIYGREQYDYV 678
            ..||:|:|.:....|..:..:..|.||.||::|:||.|..||.:   .|:.|...:...      
Mouse   670 SLLLSDVLVFTSEQCDAHRSEAACVAAGPGIRCLWDTQSSRCTSWELATEEQAEKLKSE------ 728

  Fly   679 ACPSKSRLTLTSELLHDVHRCQELASCQSCVSTAFGCTYCGNGVCSKERCRETTSMASVFFESST 743
             |.||..|.      ||  ||.:...|.||.:....|.:|      .:.|....       .|.|
Mouse   729 -CFSKRTLD------HD--RCDQHTDCYSCTANTNDCHWC------NDHCVPVN-------HSCT 771

  Fly   744 QMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLACRWDSEHNRC---------- 798
            :..:|.|.       .:|||......   .|::..:||:|:.:..|:|:..:..|          
Mouse   772 EGQISIAK-------YESCPKDNPMY---YCNKKTSCRSCALDQNCQWEPRNQECIALPENICGN 826

  Fly   799 ----------------------------------------------------------------- 798
                                                                             
Mouse   827 GWHLVGNSCLKITTAKENYDNAKLSCRNHNAFLASLTSQKKVEFVLKQLRLMQSSQSMSKLTLTP 891

  Fly   799 -----KSYTSY-----------------------------------------------GGLALNR 811
                 |...||                                               .|....|
Mouse   892 WVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLNGSVCER 956

  Fly   812 TQDEVA--CSPSCASLTNCQNCT--EDECIWCQNEQRCVDRNAYTASFPYGQCREWTTFTAKCRS 872
            ..:..|  |...||..|.|..||  ..||:||.|.::|||.|||.||||:|||.||.|.:    |
Mouse   957 PANHSAKQCRTPCALRTACGECTSSSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMS----S 1017

  Fly   873 APIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGRCVVGGALAP------- 930
            .|.::               |..|.:|..||:.|.||||.:.||||.|:|:.|....|       
Mouse  1018 CPPEN---------------CSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQA 1067

  Fly   931 ----------YDDTEC---ALKHWFFTSCPRCNCNGHSYCNDQQHCEQPCNNLTTGAHCEKCRTG 982
                      .:.:.|   :..:|.|..||.|.|||||.|.:|..||: |.:||||.|||.|.:|
Mouse  1068 SAGNVYPQPLLNSSMCLEDSRYNWSFIHCPACQCNGHSKCINQSICEK-CEDLTTGKHCETCISG 1131

  Fly   983 YWGNPINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEKCDSQNHYHGDPLKGSCYYELT 1047
            ::|:|.||||||.|.|||....|:.:||||||||||:.||.|:.|:.:|.|.|:||||:|||.|.
Mouse  1132 FYGDPTNGGKCQPCKCNGHASLCNTNTGKCFCTTKGVKGDECQLCEVENRYQGNPLKGTCYYTLL 1196

  Fly  1048 IDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAKMDISVKR---AGS---PDMLI 1106
            |||||||:||:::||::|.|||..:|.:...|.|..|..|....::|:...   ||:   .::.:
Mouse  1197 IDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFNLNITWATSFPAGTQTGEEVPV 1261

  Fly  1107 LVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQYPK-LNLQQFFIT 1170
            :...|...::..|....:.|.:.|:     .||:|:|.:|..||.|||||||:.. ::|.|||:|
Mouse  1262 VSKTNIKEYKDSFSNEKFDFRNHPN-----ITFFVYVSNFTWPIKIQIAFSQHSNFMDLVQFFVT 1321

  Fly  1171 FSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIE-NRESIDLSLTLEG 1234
            |.||||.|||:|||:|||||.....|||::|..||:|||||||:.|.|.:| :.|..||      
Mouse  1322 FFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPFASVNVALETDEEPPDL------ 1380

  Fly  1235 IGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQS 1282
            ||    ...|..|.|||||||.||:|||||:.||||.|.....|.|||
Mouse  1381 IG----GSIKTVPKPIALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQS 1424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsdNP_001263013.1 CUB 86..212 CDD:238001 58/125 (46%)
PLN02153 290..582 CDD:177814 109/297 (37%)
KELCH repeat 308..349 CDD:276965 10/42 (24%)
Kelch_5 355..391 CDD:290565 16/36 (44%)
KELCH repeat 358..420 CDD:276965 18/62 (29%)
KELCH repeat 424..474 CDD:276965 21/52 (40%)
KELCH repeat 482..531 CDD:276965 19/48 (40%)
KELCH repeat 535..588 CDD:276965 32/52 (62%)
PSI 821..870 CDD:279745 27/50 (54%)
EGF_Lam 948..994 CDD:238012 26/45 (58%)
EGF_Lam 995..1040 CDD:238012 24/44 (55%)
AtrnXP_006498669.1 CUB 168..283 CDD:238001 60/127 (47%)
PHA03098 <363..527 CDD:222983 55/185 (30%)
KELCH repeat 377..418 CDD:276965 10/40 (25%)
KELCH repeat 428..480 CDD:276965 18/64 (28%)
KELCH repeat 484..532 CDD:276965 21/53 (40%)
PHA03098 <508..668 CDD:222983 74/161 (46%)
KELCH repeat 537..586 CDD:276965 19/48 (40%)
KELCH repeat 590..645 CDD:276965 33/56 (59%)
PSI 683..729 CDD:214655 14/52 (27%)
CLECT 824..956 CDD:382969 4/131 (3%)
PSI 968..1019 CDD:366642 28/54 (52%)
EGF_Lam 1098..1143 CDD:238012 26/45 (58%)
EGF_Lam 1144..1189 CDD:238012 24/44 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 317 1.000 Domainoid score I1265
eggNOG 1 0.900 - - E1_KOG1388
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H22542
Inparanoid 1 1.050 654 1.000 Inparanoid score I774
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49386
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003093
OrthoInspector 1 1.000 - - otm43546
orthoMCL 1 0.900 - - OOG6_105013
Panther 1 1.100 - - LDO PTHR10574
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2833
SonicParanoid 1 1.000 - - X2068
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.860

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