Protein Alignment dsd and Atrn

DIOPT Version :10

• Sequence 1: NP_651571.3
• Gene: dsd / 43315
• FlyBaseID: FBgn0039528
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: XP_006498669.1
• Gene: Atrn / 11990
• MGIID: 1341628
• Length: 1510
• Species: Mus musculus
• Alignment Length: 1478
• Identity: 513/1478 - (34%)
• Similarity: 711/1478 - (48%)
• Gaps: 335/1478 - (22%)

  Fly     1 MCL------AAEPPQKQPNRSSTSPTFNAKYRRKCLLLLTLLLF-----------HGCFSGLHRA 48
            :||      |..||...|                  ||.:|||.           ....||...|
Mouse    86 LCLPRVLSRALPPPPLLP------------------LLFSLLLLPLPREAEAAAVAAAVSGSAAA 132

  Fly    49 AAFNC---TAHGGRCQNDGQCQEDGQCLCADGWQGPECQFCGGKVRMYHPMGTIHDGWGNYSVSV 110
            .|..|   ..:|||| |.|    .|||:|..||.|.:||.|||:.|:....|.:.||.|||....
Mouse   133 EAKECDRPCVNGGRC-NPG----TGQCVCPTGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKT 192

  Fly   111 KCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIYDGDSVDSPLLAVFSGLMYR 175
            ||:|||:.:           |:|.  :|:....|||||.|||||:|||||:.:||:|.||||:..
Mouse   193 KCTWLIEGQ-----------PNRI--MRLRFNHFATECSWDHLYVYDGDSIYAPLIAAFSGLIVP 244

  Fly   176 GNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCPSDSDEVECSGHGKCRDG----- 235
            ........|:|..|||.||:|||||.|||::|||:||..:.||::     |||.|:|:..
Mouse   245 ERDGNETAPEVTVTSGYALLHFFSDAAYNLTGFNITYNFDMCPNN-----CSGRGECKSSNSSSA 304

  Fly   236 -DCICDPMYRGEACNIAACPNNCFESKNQGHCRLDQER-CSCYEGFAGDDCS-QISAHGAWSTVH 297
             :|.|...::||:|:|..|.:|| ...::|.|.....| |||:..:.|..|| .:.|:.::.| .
Mouse   305 VECECSENWKGESCDIPHCTDNC-GFPHRGICNASDTRGCSCFPHWQGPGCSIPVPANQSFWT-R 367

  Fly   298 PKHSPAPAGSASHGATIWRDTLHIVGGESYGRG--KLMSTYDFNGNVWETVHPEDGSEVPDKRYG 360
            .::|......|||.|.:..:.:.:|||..:...  .::..||.....|..::....|.|  .|||
Mouse   368 EEYSDLKLPRASHKAVVNGNIMWVVGGYMFNHSDYSMVLAYDLTSREWLPLNHSVNSVV--VRYG 430

  Fly   361 ASTVMYGDKIFMYGGVVKGHG-ISNELWAFDVSARTWANISVRADPSCNATGGTTAMCGPLHVVG 424
            .|..::.|||:||||.:...| ::|||..|.:...:|..::.:|...             ..|||
Mouse   431 HSLALHKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKDQ-------------YAVVG 482

  Fly   425 HTA---TLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFASREWRIVPTTGYVVKGGYGHSA 486
            |:|   ||..|      ...|:|||||.|.|||::.|||::.....|.|:.|.|.:|:||||||:
Mouse   483 HSAHIVTLASG------RVVMLVIFGHCPLYGYISVVQEYDLEKNTWSILHTQGALVQGGYGHSS 541

  Fly   487 AYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLSAAPSARLLHTANFVNQGLMMVF 551
            .||..|:.:||:||..:.|.:...|:..||.|:..|::|::|..:...|.||||..|: |.|:||
Mouse   542 VYDDRTKALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFFRYLHTAVIVS-GTMLVF 605

  Fly   552 GGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQADLARFGHSSVVFEESLYIYGGFN 616
            |||||||||.|:||||:|.|.:.||:.||.|...|.| .|..|:.|||||:|::..::|::||||
Mouse   606 GGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRP-ELHHDVNRFGHSAVLYNSTMYVFGGFN 669

  Fly   617 GQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCIWDVQKMRCIA---ITQVQRSAIYGREQYDYV 678
            ..||:|:|.:....|..:..:..|.||.||::|:||.|..||.:   .|:.|...:...
Mouse   670 SLLLSDVLVFTSEQCDAHRSEAACVAAGPGIRCLWDTQSSRCTSWELATEEQAEKLKSE------ 728

  Fly   679 ACPSKSRLTLTSELLHDVHRCQELASCQSCVSTAFGCTYCGNGVCSKERCRETTSMASVFFESST 743
             |.||..|.      ||  ||.:...|.||.:....|.:|      .:.|....       .|.|
Mouse   729 -CFSKRTLD------HD--RCDQHTDCYSCTANTNDCHWC------NDHCVPVN-------HSCT 771

  Fly   744 QMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLACRWDSEHNRC---------- 798
            :..:|.|.       .:|||......   .|::..:||:|:.:..|:|:..:..|
Mouse   772 EGQISIAK-------YESCPKDNPMY---YCNKKTSCRSCALDQNCQWEPRNQECIALPENICGN 826

  Fly   799 ----------------------------------------------------------------- 798
                                                                             
Mouse   827 GWHLVGNSCLKITTAKENYDNAKLSCRNHNAFLASLTSQKKVEFVLKQLRLMQSSQSMSKLTLTP 891

  Fly   799 -----KSYTSY-----------------------------------------------GGLALNR 811
                 |...||                                               .|....|
Mouse   892 WVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLNGSVCER 956

  Fly   812 TQDEVA--CSPSCASLTNCQNCT--EDECIWCQNEQRCVDRNAYTASFPYGQCREWTTFTAKCRS 872
            ..:..|  |...||..|.|..||  ..||:||.|.::|||.|||.||||:|||.||.|.:    |
Mouse   957 PANHSAKQCRTPCALRTACGECTSSSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMS----S 1017

  Fly   873 APIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGRCVVGGALAP------- 930
            .|.::               |..|.:|..||:.|.||||.:.||||.|:|:.|....|
Mouse  1018 CPPEN---------------CSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQA 1067

  Fly   931 ----------YDDTEC---ALKHWFFTSCPRCNCNGHSYCNDQQHCEQPCNNLTTGAHCEKCRTG 982
                      .:.:.|   :..:|.|..||.|.|||||.|.:|..||: |.:||||.|||.|.:|
Mouse  1068 SAGNVYPQPLLNSSMCLEDSRYNWSFIHCPACQCNGHSKCINQSICEK-CEDLTTGKHCETCISG 1131

  Fly   983 YWGNPINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEKCDSQNHYHGDPLKGSCYYELT 1047
            ::|:|.||||||.|.|||....|:.:||||||||||:.||.|:.|:.:|.|.|:||||:|||.|.
Mouse  1132 FYGDPTNGGKCQPCKCNGHASLCNTNTGKCFCTTKGVKGDECQLCEVENRYQGNPLKGTCYYTLL 1196

  Fly  1048 IDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAKMDISVKR---AGS---PDMLI 1106
            |||||||:||:::||::|.|||..:|.:...|.|..|..|....::|:...   ||:   .::.:
Mouse  1197 IDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFNLNITWATSFPAGTQTGEEVPV 1261

  Fly  1107 LVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQYPK-LNLQQFFIT 1170
            :...|...::..|....:.|.:.|:     .||:|:|.:|..||.|||||||:.. ::|.|||:|
Mouse  1262 VSKTNIKEYKDSFSNEKFDFRNHPN-----ITFFVYVSNFTWPIKIQIAFSQHSNFMDLVQFFVT 1321

  Fly  1171 FSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIE-NRESIDLSLTLEG 1234
            |.||||.|||:|||:|||||.....|||::|..||:|||||||:.|.|.:| :.|..||
Mouse  1322 FFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPFASVNVALETDEEPPDL------ 1380

  Fly  1235 IGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQS 1282
            ||    ...|..|.|||||||.||:|||||:.||||.|.....|.|||
Mouse  1381 IG----GSIKTVPKPIALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQS 1424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_651571.3	CUB	86..212	CDD:238001	58/125 (46%)
		NanM	<288..391	CDD:442289	31/105 (30%)
		KELCH repeat	308..349	CDD:276965	10/42 (24%)
		NanM	343..614	CDD:442289	110/274 (40%)
		KELCH repeat	358..420	CDD:276965	18/62 (29%)
		KELCH repeat	424..474	CDD:276965	21/52 (40%)
		KELCH repeat	482..531	CDD:276965	19/48 (40%)
		KELCH repeat	535..588	CDD:276965	32/52 (62%)
		PSI	821..870	CDD:396154	27/50 (54%)
		EGF_Lam	948..994	CDD:238012	26/45 (58%)
		EGF_Lam	995..1040	CDD:238012	24/44 (55%)
Atrn	XP_006498669.1	CUB	168..283	CDD:238001	60/127 (47%)
		NanM	365..670	CDD:442289	124/328 (38%)
		KELCH repeat	377..418	CDD:276965	10/40 (25%)
		KELCH repeat	428..480	CDD:276965	18/64 (28%)
		KELCH repeat	484..532	CDD:276965	21/53 (40%)
		KELCH repeat	537..586	CDD:276965	19/48 (40%)
		KELCH repeat	590..645	CDD:276965	33/56 (59%)
		PSI	683..729	CDD:214655	14/52 (27%)
		CLECT	824..956	CDD:470576	4/131 (3%)
		PSI	968..1019	CDD:396154	28/54 (52%)
		EGF_Lam	1098..1143	CDD:238012	26/45 (58%)
		EGF_Lam	1144..1189	CDD:238012	24/44 (55%)