DRSC/TRiP Functional Genomics Resources

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Protein Alignment dsd and Megf8

DIOPT Version :9

Sequence 1:NP_001263013.1 Gene:dsd / 43315 FlyBaseID:FBgn0039528 Length:1323 Species:Drosophila melanogaster
Sequence 2:NP_446080.1 Gene:Megf8 / 114029 RGDID:621190 Length:2789 Species:Rattus norvegicus


Alignment Length:1336 Identity:308/1336 - (23%)
Similarity:443/1336 - (33%) Gaps:502/1336 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 GTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIYDGDSV 161
            |.:.||.|||||:..|.|||:|            ||....|.:......|||.:|:|::|||||.
  Rat    42 GFVTDGAGNYSVNGNCEWLIEA------------PSPQHRILLDFLFLDTECTYDYLFVYDGDSP 94

  Fly   162 DSPLLAVFSGLMYRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCPSDSDEVEC 226
            ..||||..||        ..|.|.:.|:||..|:|.|||..||:.|||.:::.:.||..     |
  Rat    95 QGPLLASLSG--------STRPPPIEASSGKMLLHLFSDANYNLLGFNASFRFSLCPGG-----C 146

  Fly   227 SGHGKCRD-GDCICDPMYRGEACNIAACPNNCFESKNQGHCRLDQERCSCYEGFAGDDCS----Q 286
            ..||:|:. |.|:|:|.:.|..|.:..|...|   .:.|.|......|.|..||.|..|.    :
  Rat   147 QNHGQCKSPGVCVCEPGWGGPDCGLQECSAYC---GSHGTCASTLGPCRCEPGFLGRACDLHLWE 208

  Fly   287 ISAHGAWSTVHPKHSPAPAGSASHGAT----IWRDTLHIVGGESYGR--GKLMSTYDFNGNVWET 345
            ....|.|   |...:..||.||..||.    .....|.:.||:...:  |.|: .|:|:.|.||:
  Rat   209 NQGAGWW---HSVSAGDPAFSARVGAAGAFLSPPGLLAVFGGQDLNKALGDLV-LYNFSTNTWES 269

  Fly   346 VHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVKGHGISNELWAFD-VSARTWANISVRADPSCNA 409
               .|.:..|..|:....|.:...:.:.||.:....::|::|||. :....|   .:.|.|:.::
  Rat   270 ---WDLTPAPAARHSHVAVAWAGFLVLMGGELANGLLTNDVWAFSPLGGGHW---ELLAPPASSS 328

  Fly   410 TGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEF--NFASR-EWRIV 471
            :       ||..:.||.|.||...       ::.|..|.:.:..:.:.:..|  :..|| .|..|
  Rat   329 S-------GPPGLAGHAAALVDDI-------WLYVSGGRTQHDLFSSGLFRFRLDHTSRGYWEQV 379

  Fly   472 PTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESE--SSQVLSSRLYAYEPATRVWSLLSA---- 530
            ...|.......|||..:...:..:.|:||....:.  |.:|.|:.|:..:  .|||:.|..    
  Rat   380 IPAGGRPPAATGHSMVFHAPSRTLLVHGGHRPSTARFSVRVNSTELFHVD--RRVWTTLKGRDGL 442

  Fly   531 -APSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSW----HYHPMPGH 590
             .|..|..|||:.:. ..|:|:|||.|....:.   |||...:..|.:.|..|    ...| ||.
  Rat   443 QGPRERAFHTASVLG-NYMVVYGGNVHTHYQEE---KCYEDGIFFYHLGCHQWVSGAELAP-PGT 502

  Fly   591 LQADLA----RFGHSSVVFEES-LYIYGGFNGQLLNDMLRYQ--------PG------YCSYYTK 636
            .:...|    |:.|.:.|...| |.:.||::|:...|::.|:        |.      |||.||.
  Rat   503 PEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDLMAYKVPPFVFQAPALDYHLDYCSMYTD 567

  Fly   637 QEKC----------------------TAARPGVKCI----------------------------- 650
            ...|                      :.|.|...|:                             
  Rat   568 HSVCSRDPECSWCQGACQSAPPPGTPSGACPAASCLGLGRLLSDCQACLAFSSPTAPPRGPGTLG 632

  Fly   651 WDVQKMRCI--------------------------------AITQ-------------------- 663
            |.|....|:                                .:||                    
  Rat   633 WCVHNESCLPRPEQARCRGEQISGTVGWWGPAPVFVTSLEACVTQSFLPGLHLLTFQQPPNASQP 697

  Fly   664 ----VQRS-------------------------------------AIYGREQYDYV--------- 678
                :.||                                     |::.|.|..:|         
  Rat   698 DKVSIVRSTTITLTPSAETDVSLVYRGFIYPMLPGGPGGPGAEDVAVWARAQRLHVLARMARGPD 762

  Fly   679 --------------------------------------------------ACPSKSRLTLT---- 689
                                                              |.|..|.|||.    
  Rat   763 TENMEEVGRWVAQQEKETRRLQRPGSSRLFPLPGRGNKYAVEIRGQLNGSAGPGHSELTLLWDRT 827

  Fly   690 -----SEL---LHDVHR---CQELASCQSCVSTAFGCTYCGN-GVC----SKERCRETTSMASVF 738
                 ||:   ..:.:|   |...:||..|::.. ||.:|.| ..|    .:..|.:..:..|:.
  Rat   828 GVPGGSEISFFFLEPYRSLACSSYSSCLGCLADQ-GCGWCLNSATCHLRQGRAHCEDDGNGESLL 891

  Fly   739 FESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLACRWDSEHNR-----C 798
                      ...|.|       ||:.||:         .:|.||:.:..|.|....||     |
  Rat   892 ----------VLVPAL-------CPLCEEH---------RDCHACTQDPFCEWHQSTNRKGDAAC 930

  Fly   799 KSYTSYGGLALNRTQDEVACSPSCASLTNCQNC--TEDECIWCQNEQRCVDRNAYTASFPYGQCR 861
             |....|..||...::   |.|.|:....|::|  ...:|.|||:...|....||.|.:|:|.||
  Rat   931 -SRRGRGRGALKNPEE---CPPLCSQRLTCEDCLANSSQCAWCQSTHTCFLFAAYLARYPHGGCR 991

  Fly   862 EWTTFT---AKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGRCV 923
            .|....   .:|||                    |..:.:|..||....||||.|..|..||||:
  Rat   992 GWDDSVHSEPRCRS--------------------CHGFLTCHECLQSHECGWCGNEDNPTLGRCL 1036

  Fly   924 VGGALAPYDDTECAL-------------KHWFFTSCP----------RC---------------- 949
            .|....|.....|:|             ..|.:..||          ||                
  Rat  1037 QGDFSGPLGGGNCSLWVGEGLGLPVALPARWAYARCPDVDECRLGLARCHPRATCLNTPLSYECH 1101

  Fly   950 -----------NCN-------GHSY--------------------------------------CN 958
                       :||       ||..                                      ||
  Rat  1102 CQRGYQGDGITHCNRTCLEDCGHGVCSGPPDFTCVCDLGWTSDLPPPTPAPGPPAPRCSRDCGCN 1166

  Fly   959 DQQHCEQ-------PCNNLTTGAHCEKCRTGYWGNPINGGKCQRCDCNGQG----VYCHPDTGKC 1012
            ...||.:       .|.:.|.|.|||:||.|.:||....|.|:.|.|||.|    .:|...:|.|
  Rat  1167 FHSHCRRRGPGYCDECQDWTWGEHCERCRPGSFGNATGSGGCRPCQCNGHGDPRRGHCDNLSGLC 1231

  Fly  1013 FCT--TKGIVGDHCEKCDSQNHYHGDP-LKGSCYYE 1045
            ||.  |:|.   ||:.|..  .|:||| ..|||:.|
  Rat  1232 FCQDHTEGA---HCQICSP--GYYGDPRAGGSCFRE 1262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsdNP_001263013.1 CUB 86..212 CDD:238001 47/114 (41%)
PLN02153 290..582 CDD:177814 77/308 (25%)
KELCH repeat 308..349 CDD:276965 13/46 (28%)
Kelch_5 355..391 CDD:290565 9/36 (25%)
KELCH repeat 358..420 CDD:276965 12/62 (19%)
KELCH repeat 424..474 CDD:276965 12/52 (23%)
KELCH repeat 482..531 CDD:276965 14/55 (25%)
KELCH repeat 535..588 CDD:276965 17/56 (30%)
PSI 821..870 CDD:279745 16/53 (30%)
EGF_Lam 948..994 CDD:238012 22/124 (18%)
EGF_Lam 995..1040 CDD:238012 19/51 (37%)
Megf8NP_446080.1 CUB 49..139 CDD:238001 44/109 (40%)
PLN02153 203..484 CDD:177814 75/310 (24%)
Kelch_4 227..276 CDD:290154 14/52 (27%)
KELCH repeat 228..275 CDD:276965 13/50 (26%)
Kelch 1 241..287 14/49 (29%)
KELCH repeat 279..331 CDD:276965 11/61 (18%)
Kelch 2 290..338 12/57 (21%)
Kelch 3 346..399 11/52 (21%)
Kelch 4 402..453 14/52 (27%)
KELCH repeat 448..510 CDD:276965 20/66 (30%)
Kelch 5 459..511 16/55 (29%)
Kelch 6 525..575 13/49 (27%)
PSI 950..998 CDD:279745 16/47 (34%)
vWFA 1011..>1035 CDD:294047 11/23 (48%)
EGF_3 1078..1112 CDD:289699 2/33 (6%)
EGF_Lam 1163..1209 CDD:238012 16/45 (36%)
EGF_Lam 1210..1259 CDD:238012 20/53 (38%)
Kelch 7 1522..1570
KELCH repeat 1566..1617 CDD:276965
Kelch 8 1580..1626
KELCH repeat 1621..1668 CDD:276965
Kelch_3 1630..1680 CDD:290151
KELCH repeat 1673..1721 CDD:276965
Kelch 10 1685..1735
Kelch_6 1728..1775 CDD:290672
KELCH repeat 1729..1773 CDD:276965
Kelch 11 1740..1787
Kelch 12 1796..1841
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2466..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2762..2789
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D32816at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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