DRSC/TRiP Functional Genomics Resources

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Protein Alignment dsd and megf8

DIOPT Version :9

Sequence 1:NP_001263013.1 Gene:dsd / 43315 FlyBaseID:FBgn0039528 Length:1323 Species:Drosophila melanogaster
Sequence 2:XP_002936442.2 Gene:megf8 / 100496850 XenbaseID:XB-GENE-1004120 Length:2730 Species:Xenopus tropicalis


Alignment Length:1669 Identity:391/1669 - (23%)
Similarity:564/1669 - (33%) Gaps:562/1669 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 GCF-SGLHRAAAFNCTAHGGRCQNDGQCQED-GQCLCADGWQGPECQFC----------GG---- 88
            |.| |.:.:.....||.|.....:.|.|..| |.|.|:|..||..|:.|          ||    
 Frog  1178 GSFGSAIQKPGCQECTCHKHGRADQGYCDRDTGLCHCSDNTQGDHCEKCASGYYGDPRNGGTCYL 1242

  Fly    89 --KVRMYHPMGT---IHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSR-TANIRIHLREFATE 147
              :.|.:.|..|   :....|:|     |.|::...........:.|.|| |..::..||   ..
 Frog  1243 ECQGRQFIPNVTSSALGSPAGSY-----CLWVLSVSENAKPCVPDVNCSRLTLTLQPDLR---VN 1299

  Fly   148 CGWDHLYIYDG-----DS----VDSPLLAVFSGLMYRGNFSIRRVPQVIATSGTALVHFFSDDAY 203
            |...::|::||     |:    .|..||..|.| ..||...|    .|.||:|..:|::.:::. 
 Frog  1300 CTHSYVYMFDGIPGFLDTGLLQSDRSLLGAFCG-QGRGATPI----TVEATTGVLVVYYEANNT- 1358

  Fly   204 NMSGFNLTYKMNSC--PSDSDEVECSGHGKCRDGDCICDPMYRGEACNIAACPNNCFESKNQGHC 266
            ..:|||.|||::.|  |....:|       |:...|:|.......:|....||.||.....||.|
 Frog  1359 EPAGFNATYKVHVCYPPCGPSQV-------CQGQKCVCRNPLSDPSCQRLVCPKNCSAEDGQGVC 1416

  Fly   267 RLDQERCSCYEGFAGDDCS-QISAHGAW-STVHPKHSPAPAGSASH--GATIWR---DTLHIVGG 324
            ......|.||.|:||:||| .::....| :.:.|:.:...|....|  |.|:..   :||.:.||
 Frog  1417 NQTLGFCLCYPGYAGEDCSLPLAGKIVWENLIDPQLTADTASRFLHRLGHTMVEGPDNTLWMFGG 1481

  Fly   325 ESYGRGKLMSTYDF--NGNVWETV--HPEDGSEVPDKRY--GASTVMYGDKIFMYGGVVKGHGIS 383
            .|...|.|.|.|.:  :...|..:  ..|.|...|..||  .|:.....:.:::.||:. ..|.|
 Frog  1482 LSLRDGVLGSVYRYAISERRWTQMLAGTEGGGPGPSSRYFHAAAYNSLRNAMYVVGGLT-AQGAS 1545

  Fly   384 NELWAFDVSARTWANISVRADPSCNATGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGH 448
            .:.|..:::...|...|....|.               |.|||.|...|       ..:::|.|:
 Frog  1546 KDFWVLNLTTLQWRLESAPLVPP---------------VAGHTLTSRRG-------SSLLLIGGY 1588

  Fly   449 SPNYGYLNTVQEFNFASREWRIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSS 513
            ||..|:.|.|.|::.....|::...||....|.|.||..|...|:..||:||.....| :...|:
 Frog  1589 SPENGFNNRVLEYSTELETWKVGHQTGTPPTGLYAHSTVYHEGTDAFYVFGGQRFHVE-AVTASA 1652

  Fly   514 RLYAYEPATRVWSLLSAA----PSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLV 574
            .||:.......||||:.:    |.:...|.|..: :..|:|.||.|....        ||..:|.
 Frog  1653 ELYSLYYPNLTWSLLAPSQGRKPLSHFFHVAAIL-RDTMIVVGGRTEQQE--------YSNHILF 1708

  Fly   575 YDVYCDSWHYHPMPGHLQADL---ARFGHSSVVFEESLYIYGGFNGQLLNDMLRY----QPGYCS 632
            |.::|:|| ..|....:...|   ...||:..|....|||.|||||..|..||..    .|  |.
 Frog  1709 YQIHCNSW-IRPNRSDMVLGLPMNKSIGHTVAVVGGRLYISGGFNGVALGRMLTLTVPSDP--CL 1770

  Fly   633 YYTKQEKCTAARPGVKCIWDVQKMRCIAITQVQRSAIYGREQYDYVACPSKSRLTLTS--ELLHD 695
            .::....|:.:..  .|:|  .:..|::.....||           .||    |.:||  .|...
 Frog  1771 LFSTNATCSQSLG--SCVW--CQHSCVSADTANRS-----------GCP----LPITSCYPLPRS 1816

  Fly   696 VHRCQELASCQSC-------VSTAFG--------CTYCGNGVC--------SKERCRETTSMASV 737
            ...|:.|.:|..|       :||...        ||.|..|.|        |:..||  .:...:
 Frog  1817 ADDCRRLKTCSECLAQHPRSMSTPLSMGSPRCKWCTNCPEGACIGNDGSCTSENDCR--INQREI 1879

  Fly   738 FFESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLACRWDSEHNR----- 797
            |..|             |...: ||..|:             |..|:|:..|.|..:..|     
 Frog  1880 FLAS-------------NCSEI-SCEASD-------------CHKCTASGKCMWTRQFKRTGETR 1917

  Fly   798 -------CKSYTSYGGLALNRTQDEVACSPSCASLTNCQN-CTEDECI--------WCQNEQRCV 846
                   ...:|.:....||.:...|..||.....|.|.| .|..:|:        |    |:||
 Frog  1918 RILSVQPTYDWTCFSHSLLNVSPMPVESSPPLPCPTPCHNYSTCHDCLSSKGADGGW----QQCV 1978

  Fly   847 DRNAYTASFPYGQCREWTTFTAKCRS---APIQSTALAVG---STTALSSAQCGYYNSCQMCLDD 905
                            |:...::|.|   .|::..|.|.|   |.|...|..|..:..|..|:..
 Frog  1979 ----------------WSVALSQCMSPTFLPMRCAAGACGRVLSGTESCSPSCSRHTHCAACIQH 2027

  Fly   906 PACGWCDNGSNTGLGRCVVGGALAPYDDTECAL--KHWFFTSCPRCN-C-NGHSYCNDQQHCEQ- 965
            |.||||......|.|.|:.||...|....:|..  ..|.|.|||..| | |.|..||:.|:|.. 
 Frog  2028 PRCGWCARREGNGDGECMEGGLNGPTQGEQCFSDDSDWAFMSCPPENECLNQHHDCNETQNCSDL 2092

  Fly   966 -------------------------------------------------------PCN------- 968
                                                                   |||       
 Frog  2093 PNGFQCTCKKGYTLHNVTGLCRPVCDHGCVNGTCVEPNRCRCDFGYVGENCSVACPCNKHSNCLG 2157

  Fly   969 -----------NLTTGAHCEKCRTGYWGNPINGG------------------------------- 991
                       |.|.|.|||||:..:.|:.||||                               
 Frog  2158 LGVEDKCEECRNNTMGTHCEKCKPLFVGSAINGGTCRSCFDFCRGNSEVCLRREEHEIALREPEK 2222

  Fly   992 -----------------------------------------------KCQRCDCNGQGVYCHP-D 1008
                                                           :|.:|.|||....|.. |
 Frog  2223 YPLDPRSVSVWVSQGPTEDTAVCVNCQNNSCGEKCDQCLPGYFLLDKRCTKCQCNGHADTCSEID 2287

  Fly  1009 TGKCFCTTKGIVGD---------------HCEKCDSQNHYHGDPLKG-SCYYELTIDYQFTFNLS 1057
            ...|.|:.....|:               .|.||  ::.:||:|:.| .||..:|::.::.|: .
 Frog  2288 GTNCPCSNNTETGNCQNSPQSEKKDCYKYQCAKC--KDSFHGNPVNGRQCYRLMTVEQEYCFD-P 2349

  Fly  1058 KKEDRHFTQINFRNSP-GKP--------------EIDADFTITCSVPAKMDISVK---RAGSPDM 1104
            ..:...|.:.|.:|.| |:.              .:..|.|..|     :|:.|.   ...|.::
 Frog  2350 TSQSNCFHEPNIQNLPFGRTVFFGVQPKFTNVDIRVTVDVTFGC-----VDVFVSTSYETFSVEV 2409

  Fly  1105 LILVGVNCSTFRHRFPKTDYQFGHSP---DDNSSLTTFYVFVH---DFQPP---IWIQIAFSQ-- 1158
            ..|.||:.....|.....|...|..|   ..|.||......:|   :.:|.   .:|.::..|  
 Frog  2410 DPLTGVHGVRVHHSQSDLDGHIGPEPLTASANGSLGRAVGKIHWLREERPRGLITYITVSNQQTV 2474

  Fly  1159 -------------YP-------------------------------------KLNLQQFFITFSS 1173
                         ||                                     .::|..||..|.|
 Frog  2475 LIVRGVRDRVVITYPHELHTLKSSRFYLLLLGNSSNGSGESQGLLFFRQDQAHIDLFVFFSVFFS 2539

  Fly  1174 CFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLV----DIENRESIDLSLTLEG 1234
            ||.|.|....:|||:||..|:.|.::|...||.:||||||:::.|    |:|         .|.|
 Frog  2540 CFFLFLSACVLLWKVKQWLDVRREQRRHLQEMSKMASRPFAKLTVYFQPDVE---------PLSG 2595

  Fly  1235 I--------------------GHLSKKRKK-------ECPS----------------------PI 1250
            .                    .|.||.|.|       :.||                      ||
 Frog  2596 CHSGGPILPSLPHHHHHHHHHHHRSKPRVKSYDPSAPQPPSLRHSDPFLSQLLGYTYCNFRVGPI 2660

  Fly  1251 ALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAGLAVASALVTL 1294
            .|||.....|.|::||::||.|  :|||:....|    ||||||
 Frog  2661 TLEPTDDGMAGVVTLLLQLPGG--AQAPNRACLG----SALVTL 2698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsdNP_001263013.1 CUB 86..212 CDD:238001 37/154 (24%)
PLN02153 290..582 CDD:177814 78/307 (25%)
KELCH repeat 308..349 CDD:276965 13/49 (27%)
Kelch_5 355..391 CDD:290565 9/37 (24%)
KELCH repeat 358..420 CDD:276965 11/63 (17%)
KELCH repeat 424..474 CDD:276965 14/49 (29%)
KELCH repeat 482..531 CDD:276965 17/48 (35%)
KELCH repeat 535..588 CDD:276965 15/52 (29%)
PSI 821..870 CDD:279745 10/57 (18%)
EGF_Lam 948..994 CDD:238012 24/199 (12%)
EGF_Lam 995..1040 CDD:238012 15/60 (25%)
megf8XP_002936442.2 CUB 39..139 CDD:238001
KELCH repeat 227..270 CDD:276965
Kelch_4 <237..268 CDD:404322
KELCH repeat 278..323 CDD:276965
PLN02153 312..>457 CDD:177814
KELCH repeat 330..371 CDD:276965
KELCH repeat 381..437 CDD:276965
PSI 936..987 CDD:396154
EGF_3 1071..1098 CDD:403986
EGF_Lam 1192..1241 CDD:238012 16/48 (33%)
Kelch_4 1462..1505 CDD:404322 13/42 (31%)
KELCH repeat 1463..1515 CDD:276965 14/51 (27%)
KELCH repeat 1519..1566 CDD:276965 10/47 (21%)
Kelch_3 1531..1576 CDD:404319 12/60 (20%)
KELCH repeat 1569..1610 CDD:276965 15/47 (32%)
Kelch_3 1579..1629 CDD:404319 16/56 (29%)
KELCH repeat 1621..1669 CDD:276965 17/48 (35%)
KELCH repeat 1673..1729 CDD:276965 16/65 (25%)
EGF_CA 2074..2108 CDD:238011 8/33 (24%)
EGF_Lam 2146..2194 CDD:238012 16/47 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D32816at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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