DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsd and atrnl1

DIOPT Version :9

Sequence 1:	NP_001263013.1	Gene:	dsd / 43315	FlyBaseID:	FBgn0039528	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_031761586.1	Gene:	atrnl1 / 100495547	XenbaseID:	XB-GENE-6033278	Length:	1405	Species:	Xenopus tropicalis

Alignment Length:	1526	Identity:	521/1526 - (34%)
Similarity:	718/1526 - (47%)	Gaps:	366/1526 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LLLLTLLLFHGC------FSGLHRAAAFNCTAHGGRCQND----GQCQEDGQCLCADGWQGPECQ 84
            |||....:.|.|      .|||.....|..::.|..|:.:    |:| .:..|||..||.|..||
Frog     2 LLLRVATMCHNCPGMSLLRSGLFYLLIFAYSSQGRACEKNPCFSGRC-VNNTCLCDPGWVGELCQ 65

  Fly    85 FCGGKVRMYHPMGTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECG 149
            .|.|:.|:..|.|.:.||..||....||:|||:. :||            |.:|:....|||||.
Frog    66 HCQGRFRLTEPSGYLTDGPINYKYKTKCTWLIEG-YPH------------AVLRLRFNHFATECS 117

  Fly   150 WDHLYIYDGDSVDSPLLAVFSGLMY---RGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLT 211
            |||:|||||||:.|||:||.|||:.   .||   ..||:|:.|||.||:|||||.|||::|||:.
Frog   118 WDHMYIYDGDSIYSPLIAVLSGLIVPEAPGN---ETVPEVVTTSGFALLHFFSDAAYNLTGFNIF 179

  Fly   212 YKMNSCPSDSDEVECSGHGKCRDGD-------CICDPMYRGEACNIAACPNNCFESKNQGHCRLD 269
            |.:|||||:     |||||||....       |.||..::||||:|..|.||| .|.:.|:|.|.
Frog   180 YSINSCPSN-----CSGHGKCTGSSLVPSRVYCECDKYWKGEACDIPYCKNNC-GSPDHGYCDLT 238

  Fly   270 QER-CSCYEGFAGDDCSQI--SAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVGGE--SYGR 329
            .|: |.|.:.:.|.|||..  |....|...:.|......|.|||.|.:....:.::||.  :|..
Frog   239 GEKLCVCNDSWQGPDCSLTVPSTDSYWILPNVKPFSPSVGRASHKAVMHGKFMWVIGGHAFNYSS 303

  Fly   330 GKLMSTYDFNGNVWETVHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVK--GHGISNELWAFDVS 392
            .:::..|:...::|..|....|   |.:|||.|..:|.|.|:||||.::  |..:::|||.|::|
Frog   304 FQMVLNYNVESSIWNVVPVLRG---PLQRYGHSLALYQDDIYMYGGKIETIGGNVTDELWVFNIS 365

  Fly   393 ARTWANISVRADPSCNATGGTTAMCGPLH--VVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYL 455
            :::|            :|...|.:....|  |.||||.:|.   ..|....||:|||:|..|||:
Frog   366 SQSW------------STRTPTVLNHGQHYAVEGHTAHIVE---LDNRDAVMVIIFGYSSVYGYI 415

  Fly   456 NTVQEFNFASREWRIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEP 520
            :.||||...|..|.:..|.|.:|:|||||::.|:.:|:.:|::||..:...:...|...||.||.
Frog   416 SNVQEFYLKSNTWLVPETRGAIVQGGYGHTSVYEPITKAIYIHGGYKALPGNKYGLVDDLYRYEV 480

  Fly   521 ATRVWSLLSAAPSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYH 585
            .||.|::|..:..:|.||||..:: |.|:||||||||||:.|.||||:|.|.|.||:.||.|...
Frog   481 NTRTWTILKESGLSRYLHTAVLIS-GTMLVFGGNTHNDTALSNGAKCFSADFLAYDIACDEWRVL 544

  Fly   586 PMPGHLQADLARFGHSSVVFEESLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCI 650
            ..| :|..|:.|||||:||...|:||:|||:..||||:|.|:|..|..:..:::||:|..|:.|:
Frog   545 QKP-NLHRDVNRFGHSAVVSNGSMYIFGGFSSVLLNDILVYKPPSCEAFRSEDQCTSAARGISCL 608

  Fly   651 WDVQKMRCIAITQVQRSAIYGREQYDYVACPSKSRLTLTSELLHDVHRCQELASCQSCVSTAFGC 715
            ||  |..|::...|:.|....|..     |.:||...        ..||.:...|.||.:...||
Frog   609 WD--KDHCVSWESVRPSRHLFRAN-----CRNKSAAA--------DDRCYKNTDCASCTANTNGC 658

  Fly   716 TYCGNGVCSKERCRETTSMASVFFESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNC 780
            .:|.:     ::|....|..||                 :.|:...|.:..|    .:|::|.:|
Frog   659 QWCDD-----KKCVSLYSNCSV-----------------SVKNYTKCYVRNE----QICNKLTSC 697

  Fly   781 RACSANLACRWDSEHNRCK-----------------------SYTSY-----------GGLALNR 811
            ::||.||.|:||.....|:                       |..||           |.||...
Frog   698 KSCSLNLNCQWDQRQQECQALPAHLCGEGWSHVGDSCLRINSSRDSYDNARVYCHNLSGSLASLT 762

  Fly   812 TQDEV------------------------------------------------------------ 816
            |..||
Frog   763 TSKEVDFVLDEMQKYTNQKLSPWVGLRKINVSYWGWEDMCPFTNTTLQWLPGEPSDSGFCAYLER 827

  Fly   817 --------------------------------ACSPSCASLTNCQNCTED--ECIWCQNEQRCVD 847
                                            .|...|:..|:|.|||.:  ||:||.|.:||||
Frog   828 AEVAGLKANPCTAMTDGLVCEKPVVSPNQNARPCKLPCSLRTSCSNCTSNGMECMWCSNAKRCVD 892

  Fly   848 RNAYTASFPYGQCREWTTFTAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCD 912
            .|||..|||||||.||                    .||..||..|..:.:|..||:.|.||||:
Frog   893 SNAYIISFPYGQCLEW--------------------QTTTCSSQNCSGFRTCAQCLEQPGCGWCN 937

  Fly   913 NGSNTGLGRCVVGGALAP------------YDDTECALK---HWFFTSCPRCNCNGHSYCNDQQH 962
            :.||||.|.||.|.:..|            .|...|..:   .|.|..||.|.|||||.|.:...
Frog   938 DPSNTGKGSCVEGSSRGPMRPLGKHSSEMVLDTGLCPREKNYEWSFIHCPACQCNGHSTCVNTNV 1002

  Fly   963 CEQPCNNLTTGAHCEKCRTGYWGNPINGGKCQR---C-DCNGQGV-------------------- 1003
            ||| |.|||.|.|||.|..||:|||.|||:|:.   | |..|.||
Frog  1003 CEQ-CKNLTMGKHCESCMPGYYGNPTNGGECEAMLLCTDYCGAGVMAEMDEQPGILFPLHSKLSS 1066

  Fly  1004 -----YCHPDTGKCFCT---------------TKGIVGDHCEKCDSQNHYHGDP----------- 1037
                 |..|:|....||               |..:|.:. :|..:..::..:|
Frog  1067 LTAPLYVRPETPPPICTREMRDYTAFLIDYQFTFSLVQEE-DKYHTAINFIANPEQMFMVICVPI 1130

  Fly  1038 LKGSCYYELTIDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAKMDIS---VKRA 1099
            |..|    |.|||||||:|.::||::.|.|||..:|.:...:.|.:|..|....::|:   ...|
Frog  1131 LTDS----LLIDYQFTFSLVQEEDKYHTAINFIANPEQSNKNLDISINASNNFNLNITWSIGSTA 1191

  Fly  1100 GS---PDMLILVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQYPK 1161
            |:   .::.::...:...:|..|....:.|..:|:     .||||:|.:|..||.|||||||:..
Frog  1192 GTISGEEVPLVSRAHIKEYRDSFSCEKFNFRSNPN-----ITFYVYVSNFTWPIKIQIAFSQHNT 1251

  Fly  1162 -LNLQQFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIE-NRE 1224
             ::|.|||:||.||||.|||:|||:|||||.....|||::|..|.:|||||||:.|.|.:| ..|
Frog  1252 IMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLMRERQQMASRPFATVDVALEVGPE 1316

  Fly  1225 SID-LSLTLEGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAGLAVA 1288
            ..| |....||           .|.|||:||||||:||||::.:.||.|.....|.||| |||:|
Frog  1317 QGDILRAPTEG-----------APKPIAIEPCSGNKAAVLTVFLCLPRGLSGVPPPGQS-GLAIA 1369

  Fly  1289 SALVTLGNPRRPSIDQHPKEPKSKRKQSQHP 1319
            |||:.:.  ::.|:|...|. ...|.:.|||
Frog  1370 SALIDIS--QQKSLDCKDKS-SCIRNRKQHP 1397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsd	NP_001263013.1	CUB	86..212	CDD:238001	62/128 (48%)
		PLN02153	290..582	CDD:177814	109/297 (37%)
		KELCH repeat	308..349	CDD:276965	10/42 (24%)
		Kelch_5	355..391	CDD:290565	17/37 (46%)
		KELCH repeat	358..420	CDD:276965	20/63 (32%)
		KELCH repeat	424..474	CDD:276965	21/49 (43%)
		KELCH repeat	482..531	CDD:276965	17/48 (35%)
		KELCH repeat	535..588	CDD:276965	30/52 (58%)
		PSI	821..870	CDD:279745	27/50 (54%)
		EGF_Lam	948..994	CDD:238012	27/45 (60%)
		EGF_Lam	995..1040	CDD:238012	15/99 (15%)
atrnl1	XP_031761586.1	CUB	67..182	CDD:238001	63/130 (48%)
		DSL	<208..254	CDD:418607	19/46 (41%)
		KELCH repeat	279..324	CDD:276965	10/44 (23%)
		PHA03098	<284..512	CDD:222983	83/246 (34%)
		Kelch_5	326..366	CDD:404696	17/39 (44%)
		KELCH repeat	329..377	CDD:276965	20/59 (34%)
		KELCH repeat	385..431	CDD:276965	22/48 (46%)
		Kelch_3	455..503	CDD:404319	17/47 (36%)
		PLN02153	474..>574	CDD:177814	53/101 (52%)
		KELCH repeat	495..550	CDD:276965	31/56 (55%)
		CLECT_attractin_like	723..849	CDD:153067	9/125 (7%)
		PSI	864..910	CDD:396154	27/65 (42%)
		EGF_Lam	988..1033	CDD:238012	27/45 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	314	1.000	Domainoid score	I1279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	653	1.000	Inparanoid score	I778
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D32816at33208
OrthoFinder	1	1.000	-	-		FOG0003093
OrthoInspector	1	1.000	-	-		otm48705
Panther	1	1.100	-	-	O	PTHR10574
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2833
SonicParanoid	1	1.000	-	-		X2068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190