DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5639 and TG

DIOPT Version :9

Sequence 1:	NP_651570.1	Gene:	CG5639 / 43314	FlyBaseID:	FBgn0039527	Length:	1511	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	1539	Identity:	319/1539 - (20%)
Similarity:	461/1539 - (29%)	Gaps:	608/1539 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QHLRRSESRRAKALEGSSVRVPRCQKNGDFDAIQCQDEKHGRDCWCVDDYGVELPGSRNETRTGV 103
            |.||..|.:|..|....:..||:|.::|.|..:|||::  ||.||||...|.|:.|||...|
Human    29 QPLRPCELQRETAFLKQADYVPQCAEDGSFQTVQCQND--GRSCWCVGANGSEVLGSRQPGR--- 88

  Fly   104 VCAEPKHCAASACRMFCP--------SGFARDPDTGCSVCRCRDPCDGLECPRGQSCQLQEVQCK 160
                     ..||..||.        ||:....||. .:.:|:|..|....    .|.:|:|||
Human    89 ---------PVACLSFCQLQKQQILLSGYINSTDTS-YLPQCQDSGDYAPV----QCDVQQVQC- 138

  Fly   161 SEPCPPLPTCKKA--------RSLANLCPAGLPLAIDDTVRPFLCG-QEPGKPQCP------PLY 210
                    .|..|        |.|..  |...|.:.:...|..|.| .:...|||.      |:
Human   139 --------WCVDAEGMEVYGTRQLGR--PKRCPRSCEIRNRRLLHGVGDKSPPQCSAEGEFMPV- 192

  Fly   211 QC------------LVESGNDYGVCCPSALTFQK-----PGICPAPDH----------------- 241
            ||            ||.|.|.:.....:..:||:     .|.|...|.
Human   193 QCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADSQGRELAETGLELLLDEI 257

  Fly   242 -----------SQYTERTGYMCGSPCSHDLECRNMEKCCFTKGCQFNCQQPGNVTSCHQAKALAD 295
                       |.:||.|.|..       |:.|.:.......| :|.|.     |.|...:..|.
Human   258 YDTIFAGLDLPSTFTETTLYRI-------LQRRFLAVQSVISG-RFRCP-----TKCEVERFTAT 309

  Fly   296 ILSINEREGRGYVPECNGPGGQFSPRQCSRNGLVCWCVDPRTGHKIKETMGAANNVNCDGWENMI 360
            ..      |..|||.|. ..|.:...||...| .|||||.:.    ||..|
Human   310 SF------GHPYVPSCR-RNGDYQAVQCQTEG-PCWCVDAQG----KEMHG-------------- 348

  Fly   361 SRSYARSFQMEQCDTNICAAVCEYGFKNDHNGCPTCECSEPCDGFKCSIGSHCEVATDPLCESGS 425
                                              |.:..||                 |.|..|.
Human   349 ----------------------------------TRQQGEP-----------------PSCAEGQ 362

  Fly   426 SLCASWPVCKPDLVYSNPCDVGTPLSDPATGEVMYCFEDRQGRS---FQPTAFFEPEPESLSKQG 487
            | |||                                |.:|..|   |..:.:|.......|.:.
Human   363 S-CAS--------------------------------ERQQALSRLYFGTSGYFSQHDLFSSPEK 394

  Fly   488 RSMSNRI-----MCPEQYKCTKLHRETENVCCPVPEKPNPAEEATGTHQQTMCEYLRDFSERMEG 547
            |..|.|:     .||...|  :|..:: .:..|:.|         |..||        ||.....
Human   395 RWASPRVARFATSCPPTIK--ELFVDS-GLLRPMVE---------GQSQQ--------FSVSENL 439

  Fly   548 TEEGMQLAVPS-------------PRCTNDGDYEGR------QCQLKKVRVTR------------ 581
            .:|.::...||             |:......:.|:      |..|.....||
Human   440 LKEAIRAIFPSRGLARLALQFTTNPKRLQQNLFGGKFLVNVGQFNLSGALGTRGTFNFSQFFQQL 504

  Fly   582 --------------AKQRKI-LEENTIRRMRMLLASAAPSASKRS-----------------RRD 614
                          ||...: |:.|:        ::..|.|:|:.                 :.:
Human   505 GLASFLNGGRQEDLAKPLSVGLDSNS--------STGTPEAAKKDGTMNKPTVGSFGFEINLQEN 561

  Fly   615 LERLK----LYRVDDSALKIQVAAPVMGRSAKVIDMGADRQQGLGQLFETEFKKVASASKRPP-- 673
            ...||    |..:.:..|.:|.|          |.:..|..:.||.:.||...  :...::.|
Human   562 QNALKFLASLLELPEFLLFLQHA----------ISVPEDVARDLGDVMETVLS--SQTCEQTPER 614

  Fly   674 --------DNENELVEMEVEQCWCVDSFGTEIPRSR---GFNVTDDTCRSLREDLDCLDLTCRMG 727
                    :...|.|:....:||||:|:|.|:|.||   |.......|...|..:..|     ||
Human   615 LFVPSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSL-----MG 674

  Fly   728 CE-YGFSLDPDTRCPACQCRDPCEGVTCGSGKECRVVDVSCEGEYCPPVPACLPRKPGQCPYLVP 791
            .: .|.:|    ..|||........|.| ...||..||  .||:..|...:.: .||.:||
Human   675 SQPAGSTL----FVPACTSEGHFLPVQC-FNSECYCVD--AEGQAIPGTRSAI-GKPKKCP---- 727

  Fly   792 PGPDNLDANTCAYECRTDAHCDGARRCCSNGCGTQCVDPQLKTACQHLQAIQLHQSSELGIPA-R 855
                                             |.|   ||::....|:.:|...|:...:|. .
Human   728 ---------------------------------TPC---QLQSEQAFLRTVQALLSNSSMLPTLS 756

  Fly   856 QMAVAQCDPNNGKWNQVQCS--PDG-----HCWCVDDQGKILPGTRVKSPATPKCQENSSFACPK 913
            ...:.||. .:|:|.||||:  |:.     ..|...::|:.|      :||....:..|......
Human   757 DTYIPQCS-TDGQWRQVQCNGPPEQVFELYQRWEAQNKGQDL------TPAKLLVKIMSYREAAS 814

  Fly   914 TNCSLECESGYQMDSNGC-PTCECRNYCNEVSCSPHEECQLISVECVDSPCPKMPICVPRR---- 973
            .|.||..:|.|:...... |.           .|.:...|.:.:..::...|:     ||.
Human   815 GNFSLFIQSLYEAGQQDVFPV-----------LSQYPSLQDVPLAALEGKRPQ-----PRENILL 863

  Fly   974 -----------------ASICPEGNPLQQGDLDMSC-----------GPHNEHEVCPT-THSCQL 1009
                             .|......||...|| .:|           |..:|....|| ..||:.
Human   864 EPYLFWQILNGQLSQYPGSYSDFSTPLAHFDL-RNCWCVDEAGQELEGMRSEPSKLPTCPGSCEE 927

  Fly  1010 NPVNNRGVCCSKTRDVCFESMDNGCLATGKSEKNSTRYRFSPKANKCLPVVIDSE----APACQT 1070
                      :|.|.:.|.......:    |..||:|:...........:.:.:|    .|....
Human   928 ----------AKLRVLQFIRETEEIV----SASNSSRFPLGESFLVAKGIRLRNEDLGLPPLFPP 978

  Fly  1071 KNLFHNELACNSVCPVLTQCERLKLKNNLAAQRT---------------GHSSVW----FQPRCD 1116
            :..|..:....|...:           .||||.|               |.|::.    :.|:||
Human   979 REAFAEQFLRGSDYAI-----------RLAAQSTLSFYQRRRFSPDDSAGASALLRSGPYMPQCD 1032

  Fly  1117 PVTGHWSPVQCLGKQPQPMDRHTEIVSRAFASEPAASAGEEAPGVCWCADKKGAPLKGTLTRESE 1181
             ..|.|.||||                         .||   .|.|||.|:||..:.|:||..|.
Human  1033 -AFGSWEPVQC-------------------------HAG---TGHCWCVDEKGGFIPGSLTARSL 1068

  Fly  1182 PI------CNS----------RQARNRK-----------AFDSGDPLMEQLIAQLTQLNDVASED 1219
            .|      |..          :|||:::           ..::|:....|.....|...|.||.:
Human  1069 QIPQCPTTCEKSRTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGE 1133

  Fly  1220 LDFDELEARVLPATASAAESSVTERVLELANSLLDSQLSVEQATLKPMELKTTRCRALSKTAPFP 1284
                  |.|  |.::|:|:..      .|.|.|....||   ..:.|..:..  |||
Human  1134 ------ELR--PGSSSSAQCP------SLCNVLKSGVLS---RRVSPGYVPA--CRA-------- 1171

  Fly  1285 VSCDEAGAFRPLQCNGR--SCWCVDAAGNQLQSTHVFGAGDRRC 1326
                |.|.|.|:||:..  |||||..:|.::..|.|.| |...|
Human  1172 ----EDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTG-GQPAC 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5639	NP_651570.1	TY	38..101	CDD:238114	25/61 (41%)
		Lustrin_cystein	180..225	CDD:291299	15/63 (24%)
		TY	286..353	CDD:238114	19/66 (29%)
		Antistasin	373..398	CDD:280912	1/24 (4%)
		WAP	784..830	CDD:278522	4/45 (9%)
		TY	836..903	CDD:238114	18/74 (24%)
		Antistasin	911..936	CDD:280912	6/25 (24%)
		Lustrin_cystein	977..1020	CDD:291299	11/54 (20%)
		TY	1090..1184	CDD:294100	30/118 (25%)
		TY	<1281..1326	CDD:238114	16/46 (35%)
TG	NP_003226.4	TY	33..92	CDD:238114	23/72 (32%)
		TY	95..160	CDD:238114	19/80 (24%)
		TY	300..358	CDD:238114	23/134 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545		5/31 (16%)
		Thyroglobulin_1	599..658	CDD:395039	16/60 (27%)
		Thyroglobulin_1	662..724	CDD:395039	20/74 (27%)
		TY	729..>776	CDD:412186	15/50 (30%)
		TY	<892..922	CDD:412186	7/30 (23%)
		TY	1004..1073	CDD:238114	25/97 (26%)
		TY	1077..1145	CDD:238114	15/75 (20%)
		TY	1149..1210	CDD:238114	24/78 (31%)
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:400166
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768
		COesterase	2197..2718	CDD:395084
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2727..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11784
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000