DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5639 and Nid2

DIOPT Version :10

Sequence 1:NP_651570.1 Gene:CG5639 / 43314 FlyBaseID:FBgn0039527 Length:1511 Species:Drosophila melanogaster
Sequence 2:NP_001012005.2 Gene:Nid2 / 302248 RGDID:1311685 Length:1396 Species:Rattus norvegicus


Alignment Length:1380 Identity:249/1380 - (18%)
Similarity:376/1380 - (27%) Gaps:609/1380 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 DPCDGLECPRGQSCQLQEVQCKSEPCPPLPTCKKARSLANLCPAGLPLAIDDTVRPFLCGQEPGK 203
            :|.:.||   |.|  ..:|...||..|..|....|..|.:..|...| :..:|....|   :|..
  Rat   331 EPGEALE---GHS--RIDVSFNSEVNPTSPDSDHASPLPHPAPGNWP-SYRETESASL---DPQT 386

  Fly   204 PQCPPLYQCLVESGNDYGVCCPSALTFQKPGICPAPDHSQYTERTGYMCGSPCSHDLECRNMEKC 268
            .|.||:.:..|             |.|:.|        ::..::||....:|             
  Rat   387 KQGPPVGEVEV-------------LDFKDP--------AELLDQTGTRTPAP------------- 417

  Fly   269 CFTKGCQFNCQQPGNVTSCHQAKALADILSINEREGRGYVPEC----NGPGGQFSP--RQCSRNG 327
               .|.......||..             .:..|:.:.| ||.    :.|....:|  |:...| 
  Rat   418 ---PGADAAFLTPGRE-------------DLGNRDTQSY-PEARPVPSEPDVPVAPLEREILPN- 464

  Fly   328 LVCWCVDPRTGHKIKETMGAANNVNCDGWENMISRSYARSFQMEQCDTNICAAVCEYGFKNDHNG 392
                  .|.:|| :....|....|   |.|:.:| |..:.|.....:...|        ::.|..
  Rat   465 ------YPESGH-VPPLSGGRYVV---GLEDHVS-SKDQVFTYNGANRETC--------EHSHGQ 510

  Fly   393 CPT-CECSEPCDGFKCSIGSHCEVATDPLCESGSSLCASWPVCKPDLVYSNPCDVGTP--LSDPA 454
            |.. ..|::...||.|    ||:          |....:...|.|:         |.|  ::...
  Rat   511 CSRHAFCTDYTTGFCC----HCQ----------SRFYGNGRHCVPE---------GAPHRVNGKV 552

  Fly   455 TGEVMYCFEDRQGRSFQPTAFFEPEPES--LSKQGRSMSNRIMCPEQYKCTKLHRETENVCCPVP 517
            :|.:..        ...|..|.:.:..:  :|..||:.:                       .:.
  Rat   553 SGHLQV--------GHMPVHFTDVDLHAYIVSNDGRAYT-----------------------AIS 586

  Fly   518 EKPNPAEEAT-------GTHQQTMCEYLRDFSERMEGTEEGMQLA----VPSPRCT-NDGDYEGR 570
            :.|.||.:|.       |     :..:|  |:....|:|.|..|.    |.....| :.|:    
  Rat   587 QIPQPAAQALLPVLPIGG-----LFGWL--FALEKPGSENGFSLTGATFVHDVEVTFHPGE---- 640

  Fly   571 QCQLKKVRVTRAKQ----RKILEENTIRRMRM------LLASAAP-------------SASKRS- 611
                ::||:|:..:    ...|..||....::      ..|..||             |:|.|| 
  Rat   641 ----ERVRITQTAEGLDPENYLSLNTNIEGQVPFIPANFTAHIAPYQEFYHHRDSVVTSSSSRSF 701

  Fly   612 ---RRDLERLKLYRVDDSALKIQVAAPVMGRSAKVIDMGADRQQGLGQLFETEFKKVASASKRPP 673
               ...:.:.:.||:|.:     :.......:.:.:.:.|.:|..:.:.|.. :.:.....:...
  Rat   702 SLISGSINQTRSYRIDQN-----ITYKACSHAPRHLAVPATQQLTVDRAFAL-YSEEEGVLRFAV 760

  Fly   674 DNENELVEMEVEQCWCVDSFGTEI-PRSRGFNVTDDTCRSLREDLDC-----LDLTCRMGCEYGF 732
            .|:...||        |||..|.: |...|.:..|.|.|       |     :|.||.  |..||
  Rat   761 TNQIGPVE--------VDSAPTAVNPCYDGSHTCDTTAR-------CHPGTGVDYTCE--CTPGF 808

  Fly   733 SLDPDTRCPACQCRDPCEGVT----CGSGKECRVVDVSCEGEY----------------C----- 772
            ..|      ...|.|..|..|    ||....|    |:..|.|                |     
  Rat   809 QGD------GRSCVDVNECATGFHRCGPNSVC----VNLVGSYRCECRSGYEFADDRHTCVLIAP 863

  Fly   773 PPVP------ACLPRKPGQC-------------PYLVPPGPDNLDANTCAYECRTDAHCDGARRC 818
            ||.|      .|.|....:|             |..|..|....|.:.||     :..|.||..|
  Rat   864 PPNPCLDGSHTCAPEGQARCIHHGGSSFSCACLPGFVGTGHQCSDVDECA-----ENRCHGAAIC 923

  Fly   819 ----------CS---NGCGTQCVD---PQ-----LKTACQ----HLQAIQLHQSSELGIPARQMA 858
                      |.   :|.|..|..   |:     || .|:    :.||...|..|.:.||     
  Rat   924 YNTPGSFSCRCQPGYHGDGFHCASDTVPEDSISGLK-PCEYQQRYAQAQHAHAGSRIHIP----- 982

  Fly   859 VAQCDPNNGKWNQVQC-SPDGHCWCVDDQGKILPGTRVKSPATPKCQENSSFACPKTNCSLECES 922
              ||| :.|.:..:|| ...|.|||||..|..:|||:....:||                     
  Rat   983 --QCD-DQGNFVPLQCHGSTGFCWCVDQNGHEVPGTQTPPGSTP--------------------- 1023

  Fly   923 GYQMDSNGCPTCECRNYCNEVSCSPHEECQLISVECVDSPCPKMPICVPRRASICPEGNPLQQGD 987
                                    ||                                       
  Rat  1024 ------------------------PH--------------------------------------- 1025

  Fly   988 LDMSCGPHNEHEVCPTTHSCQLNPVNNRGVCCSKTRDVCFESMDNGCLATGKSEKNSTRYRFSPK 1052
                |||..|             |.......|.:.|:...|                 .|..:|:
  Rat  1026 ----CGPPPE-------------PTQRPRTVCERWRESLLE-----------------HYGGTPR 1056

  Fly  1053 ANKCLPVVIDSEAPACQTKNLFHNELACNSVCPVLTQCERLKLKNNLAAQRTGHSSVWFQPRCDP 1117
            .::                                                       :.|:||.
  Rat  1057 DDQ-------------------------------------------------------YVPQCDD 1066

  Fly  1118 VTGHWSPVQCLGKQPQPMDRHTEIVSRAFASEPAASAGEEAPGVCWCADKKGAPLKGTLTRE-SE 1181
            : ||:.|:||.||.                            ..|||.||.|..|.||.::. :.
  Rat  1067 L-GHFIPLQCHGKS----------------------------DFCWCVDKDGRELPGTRSQPGTM 1102

  Fly  1182 PICNSRQARNRKAFDSGDPLMEQLIAQLTQLNDVASEDLDFDELEAR-----VLPATASAAESSV 1241
            |.|              .|.:...:.:.|...||....:....|.|:     .||...|..:...
  Rat  1103 PAC--------------IPTVAPPVVRPTPRPDVTPPAVGTFLLYAQGQQIGHLPLNGSRLQKDA 1153

  Fly  1242 TERVLELANSLLDSQLSVEQATLKPMELKTTRCRALSKTAPFPVSCDEAGAFRPLQCNGRSCWCV 1306
            ...:|.|..|::                               |..|       ..|..|..:..
  Rat  1154 ARTLLSLHGSIV-------------------------------VGID-------YDCRERMVYWT 1180

  Fly  1307 DAAGNQLQSTHVFGAGDRRCSHVPIEAVA-----IELHLTNSSGRSIRNAYDTIRRELQQLLGG- 1365
            |.||             |..|...:||.|     |...|.:..|.:|    |..||.:.....| 
  Rat  1181 DVAG-------------RTISRASLEAGAEPETIITSGLISPEGLAI----DHFRRTMYWTDSGL 1228

  Fly  1366 ESVENLRVQENFDGS 1380
            :.:|    :...|||
  Rat  1229 DKIE----RAGLDGS 1239

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5639NP_651570.1 TY 38..101 CDD:238114
WAP 232..281 CDD:459672 5/48 (10%)
TY 286..353 CDD:238114 13/72 (18%)
Antistasin 373..398 CDD:460713 3/25 (12%)
WAP 782..830 CDD:459672 15/76 (20%)
TY 836..903 CDD:238114 25/71 (35%)
Antistasin 911..936 CDD:460713 0/24 (0%)
Thyroglobulin_1 1090..1184 CDD:459665 20/94 (21%)
TY <1281..1326 CDD:238114 8/44 (18%)
Nid2NP_001012005.2 NIDO 108..274 CDD:214712
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..393 14/50 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..452 11/73 (15%)
EGF_3 504..539 CDD:463759 10/56 (18%)
nidG2 543..767 CDD:238158 42/275 (15%)
EGF_3 779..815 CDD:463759 12/50 (24%)
EGF_CA 817..859 CDD:214542 9/45 (20%)
EGF_3 912..945 CDD:463759 9/37 (24%)
TY 960..1021 CDD:238114 23/68 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1013..1036 12/123 (10%)
Thyroglobulin_1 1040..1105 CDD:459665 25/165 (15%)
LY 1155..1193 CDD:214531 12/88 (14%)
LDL-receptor class B 1 1175..1218 14/59 (24%)
LY 1199..1241 CDD:214531 12/49 (24%)
LDL-receptor class B 2 1219..1261 6/25 (24%)
LY 1242..1286 CDD:214531
LDL-receptor class B 3 1262..1306
LY 1287..1329 CDD:214531
LDL-receptor class B 4 1307..1348
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.